Compare Glyburide vs. metformin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Diabeta
(glyburide)

Glucophage
(metformin)

Lowers blood sugar. Glyburide is a very effective oral blood sugar-lowering medicine, but has more side effects and restrictions compared to other medicines in this class (sulfonylureas).Lowers blood sugar. Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects.
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Coupons for Glyburide
Best available price for 60 (5mg) tablets of glyburide
Coupons for metformin
Best available price for 60 (500mg) tablets of metformin
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.42Glyburide
Reviews for Diabeta (glyburide)
45%
of people (All ages) say Diabeta (glyburide) is worth it
34%
say it works well
21%
say it's a big hassle
110 reviews
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
Reviews for Glucophage (metformin)
65%
+20% better vs. Diabeta (glyburide)
46%
+12% better vs. Diabeta (glyburide)
16%
+5% better vs. Diabeta (glyburide)
938 reviews
Have you used Glucophage (metformin)?
Worth itNot sureNot worth it
Side effects
Glyburidemetformin
  • Gastrointestinal disturbances 2%
  • Allergic skin reactions 2%
More Glyburide side effects »
  • Diarrhea 41%
  • Nausea/vomiting 18%
  • Gas 6%
  • Weakness 3%
  • Indigestion 3%
  • Stomach pain 1%
  • Headache 1%
More metformin side effects »
How it works
Glyburidemetformin
Glyburide is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.Glucophage (metformin) is an anti-diabetic drug. It lowers the amount of sugar your body makes or absorbs, and allows your body use the existing insulin better.
Type of medication
Glyburidemetformin
Prescription only
Prescription only
Available as
Glyburidemetformin
  • Pill
  • Pill
  • Extended release pill
  • Liquid
Used for
Glyburidemetformin
Risk factors for serious side effects
Glyburidemetformin
  • Elderly
  • Use of other blood sugar lowering medicines
  • Alcohol
  • Intense physical activity
  • History of sulfa allergies
Detailed Diabeta (glyburide) risks & warnings »
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
Detailed Glucophage (metformin) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
Glyburidemetformin
  • Avoid drinking alcohol.
  • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
  • Limit or avoid alcohol when taking this medicine.
Food
Glyburidemetformin
  • Eat regular, balanced meals to avoid low blood sugar.
  • Always take it with food to lessen stomach upset.
Kidneys and liver
Glyburidemetformin
  • Not a good choice for people with kidney problems because it's processed by the kidneys.
  • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
  • Glucophage (metformin) can cause this rare life-threatening condition. Your doctor will check your kidneys and liver before you start. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. You're more likely to get this if you already have kidney problems. Glucophage (metformin) should be stopped 48 hours before and after surgery or any imaging procedure needing contrast dye.
Weight
Glyburidemetformin
  • Can cause mild weight gain (2 to 3 pounds).
  • Can cause weight gain, dizziness, or stomach upset.
  • Doesn't cause weight gain.
Upsides and benefits
Glyburidemetformin
  • Oral blood sugar-lowering medicine.
  • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
  • One of the least expensive diabetes medicines.
  • Improves sugar control and lowers A1c levels as much as 2%.
  • One of the few diabetes medicines that lowers the risk of death from diabetes-related complications.
  • Doesn't cause weight gain.
  • Rarely causes low blood sugar.
Downsides and risks
Glyburidemetformin
  • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
  • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
  • Can cause mild weight gain (2 to 3 pounds).
  • Not preferred for people 65 years or older since it can cause prolonged low blood sugar (more than 12 hours).
  • Not a good choice for people with kidney problems because it's processed by the kidneys.
  • Loses effectiveness over time or as your body stops making insulin.
  • Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping.
  • Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take.
  • Excessive or chronic alcohol use can increase the risk of a dangerous side effect.
Tips from our pharmacists for people taking the medication
Glyburidemetformin
  • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
  • Can cause weight gain, dizziness, or stomach upset.
  • Avoid drinking alcohol.
  • Eat regular, balanced meals to avoid low blood sugar.
  • Check your blood sugar regularly.
  • Can cause upset stomach with nausea and especially diarrhea in the first couple of weeks.
  • Always take it with food to lessen stomach upset.
  • Stay hydrated.
  • Limit or avoid alcohol when taking this medicine.
  • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
  • Check your blood sugar regularly.
Learn more
More about GlyburideSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
More about metforminSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Glucophage (metformin)?
Worth itNot sureNot worth it