Compare glyburide vs. Precose

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Diabeta
(glyburide)

Precose
(acarbose)

Lowers blood sugar. Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.Lowers blood sugar. Precose (acarbose) helps lower your post-mealtime blood sugar levels, but it must be taken at the beginning of each main meal in order for it to be most effective.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.42glyburide
Reviews for glyburide
45%
of people (All ages) say glyburide is worth it
34%
say it works well
21%
say it's a big hassle
110 reviews
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it

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Have you used Precose (acarbose)?
Worth itNot sureNot worth it
Side effects
glyburidePrecose
  • Nausea and heartburn 2%
  • Skin allergies 2%
More glyburide side effects »
  • Excessive gas 46%
  • Diarrhea 19%
  • Stomach pain 10%
More Precose side effects »
How it works
glyburidePrecose
Diabeta (glyburide) stimulates your body to release insulin and lower blood sugar.Precose (acarbose) stops an enzyme in your body from turning carbohydrates into sugar for energy. As a result, your body will absorb less sugar from the foods that you eat which will lead to lower blood sugar levels.
Type of medication
glyburidePrecose
Prescription onlyPrescription only
Available as
glyburidePrecose
  • Pill
  • Pill
Used for
glyburidePrecose
Risk factors for serious side effects
glyburidePrecose
  • Over age 65
  • Kidney problems
  • Use of other blood sugar lowering medicines
  • Alcohol
  • Intense physical activity
Detailed Diabeta (glyburide) risks & warnings »
  • Using insulin or other medicines that stimulate insulin release
  • Those with kidney problems
  • Taking multiple medicines together
Detailed Precose (acarbose) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
glyburidePrecose
No interactions related info.
  • Has relatively few interactions with other medicines.
Alcohol
glyburidePrecose
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
No alcohol related info.
Food
glyburidePrecose
  • Eat well-balanced meals to avoid low blood sugar.
No food related info.
Kidneys and liver
glyburidePrecose
  • Not ideal for elderly or those with poor kidney function.
  • Precose (acarbose) is not a recommended treatment option if you have bad kidney function or kidney problems. Your doctor will have you do a blood test to decide if this is the right medicine for you.
Pain
glyburidePrecose
No pain related info.
  • Causes side effects usually during the first few weeks of treatment including stomach pain, excessive gas, and diarrhea that will become less bothersome with time.
Weight
glyburidePrecose
  • Can cause weight gain, dizziness, or stomach upset.
  • Can cause weight gain (about 2 to 3 pounds).
  • Precose (acarbose) helps control meal-time blood sugar levels without causing weight gain.
Upsides and benefits
glyburidePrecose
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
  • Precose (acarbose) helps control meal-time blood sugar levels without causing weight gain.
  • When used alone it doesn't normally cause blood sugar levels to be too low unlike other anti-diabetes medicines.
  • Safe to be used in people age 65 or older.
  • Has relatively few interactions with other medicines.
Downsides and risks
glyburidePrecose
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
  • Not a first choice medicine because it isn't as effective at lowering blood sugar compared to other treatment options.
  • Associated with bothersome side effects like excessive gas and diarrhea.
  • Relatively more expensive than other diabetes medicines.
  • Has to be taken three times a day with each meal.
  • Might cause episodes of low blood sugar when taken together with insulin or medicines that stimulate insulin release.
Tips from our pharmacists for people taking the medication
glyburidePrecose
  • Check your blood sugar regularly.
  • Eat well-balanced meals to avoid low blood sugar.
  • Works best if you take it 30 minutes before first main meal of the day.
  • Can cause weight gain, dizziness, or stomach upset.
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
  • Take Precose (acarbose) with the first bite of each main meal.
  • Don't take the medicine for the times you have skipped a meal.
  • Causes side effects usually during the first few weeks of treatment including stomach pain, excessive gas, and diarrhea that will become less bothersome with time.
  • You should continue to maintain a healthy diet, exercise regularly, and monitor your blood sugar levels while taking Precose (acarbose).
  • Your doctor will work with you to increase your dose gradually.
  • Carry glucose tablets with you at all times so that you can take them when your blood sugar drops to dangerously low levels. This is more likely to happen if you are also using insulin or a medicine that stimulates insulin release.
Learn more
More about glyburideSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
More about PrecoseSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Precose (acarbose)?
Worth itNot sureNot worth it