Compare Glyxambi vs. Glucovance

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Glyxambi (empaglifozin / linagliptin)

Prescription only

Glyburide / Metformin

Prescription only
Lowers blood sugar.

Glyxambi (empaglifozin / linagliptin) is a combination drug that lowers the number of pills you have to take, but may be more expensive than the individual components.

Lowers blood sugar.

Glyburide / Metformin is an effective combination medicine for lowering blood sugar, but it is likely to cause diarrhea in the first few weeks.

Upsides
  • Lowers A1c levels by 1.0-1.5%.
  • Can cause weight loss.
  • Taken once daily.
  • Can lower the risk of death in those with underlying heart disease.
  • Glyburide / Metformin effectively lowers blood sugar levels more so than if each of the individual medicines it contains are taken alone.
  • Protects your organs and blood vessels from the harmful effects of high blood sugar levels.
  • Can potentially lower your "bad cholesterol" levels.
  • Glyburide / Metformin is available in a generic form and is cheaper than many other combination diabetes medicines.
Downsides
  • May not be good for people who have kidney problems.
  • Not available as a generic, so can be more expensive than other diabetes medications.
  • Can increase likelihood of urinary tract or yeast infections.
  • May cause you to urinate more frequently throughout the day.
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • Glyburide / Metformin is likely to cause nausea, stomach upset, or diarrhea in the first few weeks.
  • Not a good treatment option for those with kidney and/or liver problems.
  • Drinking large amounts of or frequently using alcohol while taking Glyburide / Metformin can cause harm to your body.
  • Can cause some weight gain.
Used for
Dosage forms
  • Pill
  • Pill
Price
Lowest price near you
$549.57
Find instant savings
Lowest price near you
$14.4
Find instant savings
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
Reviews
Not enough review data.Leave a review
Not enough review data.Leave a review
Side effects
4possible side effects
  • Urinary tract infection
    13%
  • Upper respiratory tract infection
    7%
  • Common cold
    6%
  • Low blood sugar
    2%
See more detailed side effects
6possible side effects
  • Upper respiratory infection
    17%
  • Diarrhea
    17%
  • Headache
    9%
  • Nausea/vomiting
    8%
  • Stomach pain
    7%
  • Dizziness
    6%
See more detailed side effects
Risks and warnings
  • Danger from acid (ketones) build up

    Kidney problems

    ...and 7 more risk factors

  • Low blood pressure

    Taking blood pressure lowering medications

    ...and 3 more risk factors

  • Bone fractures

    Low blood pressure

    ...and 1 more risk factors

  • Urinary tract or genital area infections

    History of urinary tract infections

    ...and 2 more risk factors

  • Pancreas swelling (pancreatitis)

    History of pancreatitis

    ...and 3 more risk factors

  • Kidney damage

    History of kidney damage

    ...and 3 more risk factors

  • Low blood sugar

    Taking other diabetic medications

    ...and 4 more risk factors

See more detailed risks and warnings
  • Lactic acid build up in blood

    History of kidney problems

    ...and 5 more risk factors

  • Low blood sugar

    Skipping meals or having inconsistent meal times

    ...and 4 more risk factors

  • Severe allergic reaction

    History of allergy to sulfa-containing medicine

  • Breakdown of red blood cells

    People with G6PD deficiency

See more detailed risks and warnings