Compare Glyxambi vs. Glucovance

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Glyxambi
(empaglifozin / linagliptin)

glyburide / metformin

Lowers blood sugar. Glyxambi (empaglifozin / linagliptin) is a combination drug that lowers the number of pills you have to take, but may be more expensive than the individual components.Lowers blood sugar. Glyburide / Metformin is an effective combination medicine for lowering blood sugar, but it is likely to cause diarrhea in the first few weeks.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for Glucovance
Best available price for 120 (5mg/500mg) tablets of glucovance
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Glyxambi (empaglifozin / linagliptin)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Glyburide / Metformin?
Worth itNot sureNot worth it
Side effects
GlyxambiGlucovance
  • Urinary tract infection 13%
  • Ear, nose, or throat infection 7%
  • Common cold 6%
  • Low blood sugar 2%
More Glyxambi side effects »
  • Upper respiratory infection 3%
  • Diarrhea 11%
  • Nausea/vomiting 2%
  • Stomach pain 3%
  • Dizziness 2%
  • Gastrointestinal side effects (diarrhea, nausea/vomiting, and stomach pain) 8%
  • Low blood sugar 8%
More Glucovance side effects »
How it works
GlyxambiGlucovance
Glyxambi (empaglifozin / linagliptin) contains 2 anti-diabetes medicines. Empagliflozin lowers blood sugar by increasing secretion of blood sugar into your urine, while linagliptin helps your body produce more insulin and less glucagon.Glyburide / Metformin combines 2 prescription medicines (glyburide and metformin) into 1 pill to help treat diabetes. Glyburide stimulates your body to release insulin to lower blood sugar. Metformin helps your body use its own insulin more effectively as well as lowers the amount of sugar your body naturally makes and absorbs from food.
Type of medication
GlyxambiGlucovance
Prescription onlyPrescription only
Available as
GlyxambiGlucovance
  • Pill
  • Pill
Used for
GlyxambiGlucovance
Risk factors for serious side effects
GlyxambiGlucovance
  • Kidney problems
  • Liver problems
  • Alcohol use
  • Age 65 or older
  • Surgery
Detailed Glyxambi (empaglifozin / linagliptin) risks & warnings »
  • History of kidney problems
  • History of liver problems
  • Those with congestive heart failure
  • Using contrast dye for procedures
  • Undergoing surgery
Detailed Glyburide / Metformin risks & warnings »
Pregnancy
Alcohol
GlyxambiGlucovance
No alcohol related info.
  • Limit the amount of alcohol you drink while taking Glyburide / Metformin.
  • Drinking large amounts of or frequently using alcohol while taking Glyburide / Metformin can cause harm to your body.
Food
GlyxambiGlucovance
  • Take in the morning by mouth with or without food.
No food related info.
Kidneys and liver
GlyxambiGlucovance
  • Rarely, Glyxambi (empaglifozin / linagliptin) can hurt the kidneys. This is more likely to happen if you already have kidney damage, heart failure, or take certain medicines for blood pressure or anti-inflammatories (NSAIDs). Your doctor will check your kidneys by blood tests regularly, and might ask you to change how you take Glyxambi (empaglifozin / linagliptin).
  • May not be good for people who have kidney problems.
  • Not a good treatment option for those with kidney and/or liver problems.
Weight
GlyxambiGlucovance
  • Can cause weight loss.
  • Can cause some weight gain.
Upsides and benefits
GlyxambiGlucovance
  • Lowers A1c levels by 1.0-1.5%.
  • Can cause weight loss.
  • Taken once daily.
  • Can lower the risk of death in those with underlying heart disease.
  • Glyburide / Metformin effectively lowers blood sugar levels more so than if each of the individual medicines it contains are taken alone.
  • Protects your organs and blood vessels from the harmful effects of high blood sugar levels.
  • Can potentially lower your "bad cholesterol" levels.
  • Glyburide / Metformin is available in a generic form and is cheaper than many other combination diabetes medicines.
Downsides and risks
GlyxambiGlucovance
  • May not be good for people who have kidney problems.
  • Not available as a generic, so can be more expensive than other diabetes medications.
  • Can increase likelihood of urinary tract or yeast infections.
  • May cause you to urinate more frequently throughout the day.
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • Glyburide / Metformin is likely to cause nausea, stomach upset, or diarrhea in the first few weeks.
  • Not a good treatment option for those with kidney and/or liver problems.
  • Drinking large amounts of or frequently using alcohol while taking Glyburide / Metformin can cause harm to your body.
  • Can cause some weight gain.
Tips from our pharmacists for people taking the medication
GlyxambiGlucovance
  • Take in the morning by mouth with or without food.
  • Make sure to stay hydrated as Glyxambi (empaglifozin / linagliptin) may cause you to urinate more often.
  • Practice good genital hygiene to reduce likelihood of yeast or urinary tract infections.
  • Check your blood sugar regularly.
  • Let your doctor know of any persistent dizziness, joint pain, cold-like symptoms, repeat yeast infections or urinary infections.
  • Get immediate medical attention if you have unexplained nausea/vomiting.
  • Check your blood sugar regularly.
  • Wear sunscreen and appropriate clothing to protect yourself from the sun.
  • Take the medicine with meals to prevent an upset stomach.
  • Tell your doctor right away if you experience rapid breathing, ongoing nausea, vomiting, or stomach pain.
  • Limit the amount of alcohol you drink while taking Glyburide / Metformin.
Learn more
More about GlyxambiSide effectsAlternativesFDA package insert
Have you used Glyxambi (empaglifozin / linagliptin)?
Worth itNot sureNot worth it
More about GlucovanceSide effectsAlternativesFDA package insert
Have you used Glyburide / Metformin?
Worth itNot sureNot worth it