Compare Glyxambi vs. Invokana

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Glyxambi
(empaglifozin / linagliptin)

Invokana
(canagliflozin)

Lowers blood sugar. Glyxambi (empaglifozin / linagliptin) is a combination drug that lowers the number of pills you have to take, but may be more expensive than the individual components.Lowers blood sugar. Invokana (canagliflozin) can be used together with other diabetes medicines to help lower your blood sugar, but it can be expensive because it's brand name.
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Coupons for Invokana
Best available price for 30 (300mg) tablets of invokana
Reviews & ratings
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Have you used Glyxambi (empaglifozin / linagliptin)?
Worth itNot sureNot worth it
Reviews for Invokana
67%
-67% worse vs. Glyxambi
56%
-56% worse vs. Glyxambi
19%
+19% better vs. Glyxambi
Have you used Invokana (canagliflozin)?
Worth itNot sureNot worth it
Side effects
GlyxambiInvokana
  • Urinary tract infection 13%
  • Ear, nose, or throat infection 7%
  • Common cold 6%
  • Low blood sugar 2%
More Glyxambi side effects »
  • Yeast infection in women 8%
  • Urinary tract infections 2%
  • Increased urination 4%
  • Yeast infection in men 3%
  • Thirst 3%
  • Vaginal itching 2%
  • Constipation 1%
  • Abdominal pain 1%
More Invokana side effects »
How it works
GlyxambiInvokana
Glyxambi (empaglifozin / linagliptin) contains 2 anti-diabetes medicines. Empagliflozin lowers blood sugar by increasing secretion of blood sugar into your urine, while linagliptin helps your body produce more insulin and less glucagon.Invokana (canagliflozin) is an anti-diabetes medication. It lowers blood sugar by causing your body to get rid of sugar in your urine.
Type of medication
GlyxambiInvokana
Prescription onlyPrescription only
Available as
GlyxambiInvokana
  • Pill
  • Pill
Used for
GlyxambiInvokana
Risk factors for serious side effects
GlyxambiInvokana
  • Kidney problems
  • Liver problems
  • Alcohol use
  • Age 65 or older
  • Surgery
Detailed Glyxambi (empaglifozin / linagliptin) risks & warnings »
  • History of amputations 
  • Peripheral vascular disease (narrowed blood vessels)
  • Nerve problems
  • Diabetic foot ulcers 
  • History of kidney damage
Detailed Invokana (canagliflozin) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
GlyxambiInvokana
No alcohol related info.
  • Avoid if you are a heavy drinker of alcohol.
Food
GlyxambiInvokana
  • Take in the morning by mouth with or without food.
  • Take once daily before your first meal of the day.
  • You only have to take Invokana (canagliflozin) once a day before meals.
Kidneys and liver
GlyxambiInvokana
  • Rarely, Glyxambi (empaglifozin / linagliptin) can hurt the kidneys. This is more likely to happen if you already have kidney damage, heart failure, or take certain medicines for blood pressure or anti-inflammatories (NSAIDs). Your doctor will check your kidneys by blood tests regularly, and might ask you to change how you take Glyxambi (empaglifozin / linagliptin).
  • May not be good for people who have kidney problems.
  • Not for people with severe kidney problems.
Pain
GlyxambiInvokana
No pain related info.
  • Rarely, Invokana (canagliflozin) can hurt the kidneys. This is more likely to happen if you already have kidney damage, heart failure, or take certain medicines for blood pressure or anti-inflammatories (NSAIDs). Invokana (canagliflozin) can also lower your blood pressure since it makes you urinate more. Your doctor will check your kidneys by blood tests regularly, and might ask you to change how you take Invokana (canagliflozin). Make sure to stay hydrated to prevent low blood pressure and kidney problems.
Weight
GlyxambiInvokana
  • Can cause weight loss.
No weight related info.
Upsides and benefits
GlyxambiInvokana
  • Lowers A1c levels by 1.0-1.5%.
  • Can cause weight loss.
  • Taken once daily.
  • Can lower the risk of death in those with underlying heart disease.
  • Lowers A1C (blood sugar) levels by 1%.
  • You only have to take Invokana (canagliflozin) once a day before meals.
  • Less likely to cause low blood sugar than other diabetes medicines.
  • Also available as a combination drug with metformin (Invokamet).
Downsides and risks
GlyxambiInvokana
  • May not be good for people who have kidney problems.
  • Not available as a generic, so can be more expensive than other diabetes medications.
  • Can increase likelihood of urinary tract or yeast infections.
  • May cause you to urinate more frequently throughout the day.
  • You're more likely to have broken bones, yeast infections and urinary tract infections with Invokana (canagliflozin).
  • There's a rare but serious risk of leg and foot amputations with Invokana (canagliflozin). Talk to your doctor if you develop new pain or infections in your feet.
  • Not for people with severe kidney problems.
  • Can raise your cholesterol.
  • Avoid if you are a heavy drinker of alcohol.
Tips from our pharmacists for people taking the medication
GlyxambiInvokana
  • Take in the morning by mouth with or without food.
  • Make sure to stay hydrated as Glyxambi (empaglifozin / linagliptin) may cause you to urinate more often.
  • Practice good genital hygiene to reduce likelihood of yeast or urinary tract infections.
  • Check your blood sugar regularly.
  • Let your doctor know of any persistent dizziness, joint pain, cold-like symptoms, repeat yeast infections or urinary infections.
  • Get immediate medical attention if you have unexplained nausea/vomiting.
  • Take once daily before your first meal of the day.
  • Invokana (canagliflozin) can cause you to urinate more, so be sure to stay hydrated.
  • Can cause genital yeast infections in females and males.
  • Can cause urinary tract infections (UTI).
  • Can cause low blood sugar, so make sure to check your blood sugar if you don't feel well.
  • You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Invokana (canagliflozin).
Learn more
More about GlyxambiSide effectsAlternativesFDA package insert
Have you used Glyxambi (empaglifozin / linagliptin)?
Worth itNot sureNot worth it
More about InvokanaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Invokana (canagliflozin)?
Worth itNot sureNot worth it