Compare Glyxambi vs. Invokana

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Glyxambi (empaglifozin / linagliptin)

Prescription only

Invokana (canagliflozin)

Prescription only
Lowers blood sugar.

Glyxambi (empaglifozin / linagliptin) is a combination drug that lowers the number of pills you have to take, but may be more expensive than the individual components.

Lowers blood sugar.

Invokana (canagliflozin) can be used together with other diabetes medicines to help lower your blood sugar, but it can be expensive because it's brand name.

5.5/ 7 average rating with 27 reviewsforInvokana
Upsides
  • Lowers A1c levels by 1.0-1.5%.
  • Can cause weight loss.
  • Taken once daily.
  • Can lower the risk of death in those with underlying heart disease.
  • Lowers A1C (blood sugar) levels by 1%.
  • You only have to take Invokana (canagliflozin) once a day before meals.
  • Less likely to cause low blood sugar than other diabetes medicines.
  • Also available as a combination drug with metformin (Invokamet).
Downsides
  • May not be good for people who have kidney problems.
  • Not available as a generic, so can be more expensive than other diabetes medications.
  • Can increase likelihood of urinary tract or yeast infections.
  • May cause you to urinate more frequently throughout the day.
  • You're more likely to have broken bones, yeast infections and urinary tract infections with Invokana (canagliflozin).
  • There's a rare but serious risk of leg and foot amputations with Invokana (canagliflozin). Talk to your doctor if you develop new pain or infections in your feet.
  • Not for people with severe kidney problems.
  • Can raise your cholesterol.
  • Avoid if you are a heavy drinker of alcohol.
Used for
Dosage forms
  • Pill
  • Pill
Price
Lowest price near you
$549.57
Find instant savings
Lowest price near you
$444.76
Find instant savings
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
Reviews
Not enough review data.Leave a review
27 
67%
think this treatment is worth it
56%
think this treatment works well
19%
think this treatment is a hassle

Have you used Invokana (canagliflozin)?

Leave a review
Side effects
4possible side effects
  • Urinary tract infection
    13%
  • Upper respiratory tract infection
    7%
  • Common cold
    6%
  • Low blood sugar
    2%
See more detailed side effects
9possible side effects
  • Yeast infection in women
    11%
  • Urinary tract infections
    6%
  • Increased urination
    5%
  • Yeast infection in men
    4%
  • Thirst
    3%
  • Vaginal itching
    2%
  • Constipation
    2%
  • Nausea
    2%
  • Abdominal pain
    2%
See more detailed side effects
Risks and warnings
  • Danger from acid (ketones) build up

    Kidney problems

    ...and 7 more risk factors

  • Low blood pressure

    Taking blood pressure lowering medications

    ...and 3 more risk factors

  • Bone fractures

    Low blood pressure

    ...and 1 more risk factors

  • Urinary tract or genital area infections

    History of urinary tract infections

    ...and 2 more risk factors

  • Pancreas swelling (pancreatitis)

    History of pancreatitis

    ...and 3 more risk factors

  • Kidney damage

    History of kidney damage

    ...and 3 more risk factors

  • Low blood sugar

    Taking other diabetic medications

    ...and 4 more risk factors

See more detailed risks and warnings
  • Increased risk of leg and foot amputations

    History of amputations 

    ...and 3 more risk factors

  • Kidney damage and low blood pressure

    History of kidney damage

    ...and 3 more risk factors

  • Low blood sugar (hypoglycemia)

    Taking medicines for diabetes

  • Increased acid and ketones in the blood

    Long periods of fasting

    ...and 3 more risk factors

See more detailed risks and warnings