Compare Glyxambi vs. Onglyza

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Glyxambi (empaglifozin / linagliptin)

Prescription only

Onglyza (saxagliptin)

Prescription only
Lowers blood sugar.

Glyxambi (empaglifozin / linagliptin) is a combination drug that lowers the number of pills you have to take, but may be more expensive than the individual components.

Lowers blood sugar.

Onglyza (saxagliptin) can cause heart failure unlike other medicines that work just like it.

Upsides
  • Lowers A1c levels by 1.0-1.5%.
  • Can cause weight loss.
  • Taken once daily.
  • Can lower the risk of death in those with underlying heart disease.
  • DRUG-NAME is an oral blood sugar lowering medicine. It's a good option if you don't like injections.
  • Does not cause weight gain.
  • May be a good option for those with bad liver function.
  • Does not cause hypoglycemia (low blood sugar) when taken by itself.
Downsides
  • May not be good for people who have kidney problems.
  • Not available as a generic, so can be more expensive than other diabetes medications.
  • Can increase likelihood of urinary tract or yeast infections.
  • May cause you to urinate more frequently throughout the day.
  • Typically not first-choice treatment for diabetes.
  • Only lowers A1C (average blood sugar over time) by ~0.5%.
  • Risk for heart failure has not been seen in other medicines that work just like it.
  • May be more expensive than other anti-diabetic medicines.
Used for
Dosage forms
  • Pill
  • Pill
Price
Lowest price near you
$549.57
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Lowest price near you
$402.35
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Reviews
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Side effects
4possible side effects
  • Urinary tract infection
    13%
  • Upper respiratory tract infection
    7%
  • Common cold
    6%
  • Low blood sugar
    2%
See more detailed side effects
The Onglyza (saxagliptin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Danger from acid (ketones) build up

    Kidney problems

    ...and 7 more risk factors

  • Low blood pressure

    Taking blood pressure lowering medications

    ...and 3 more risk factors

  • Bone fractures

    Low blood pressure

    ...and 1 more risk factors

  • Urinary tract or genital area infections

    History of urinary tract infections

    ...and 2 more risk factors

  • Pancreas swelling (pancreatitis)

    History of pancreatitis

    ...and 3 more risk factors

  • Kidney damage

    History of kidney damage

    ...and 3 more risk factors

  • Low blood sugar

    Taking other diabetic medications

    ...and 4 more risk factors

See more detailed risks and warnings
  • inflammation of the pancreas

    Alcoholism

    ...and 3 more risk factors

  • Heart failure

    History of heart failure

    ...and 1 more risk factors

  • Low blood sugar (hypoglycemia)

    Alcohol

    ...and 3 more risk factors

See more detailed risks and warnings