Compare Glyxambi vs. Onglyza

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Glyxambi
(empaglifozin / linagliptin)

Onglyza
(saxagliptin)

Lowers blood sugar. Glyxambi (empaglifozin / linagliptin) is a combination drug that lowers the number of pills you have to take, but may be more expensive than the individual components.Lowers blood sugar. Onglyza (saxagliptin) can cause heart failure unlike other medicines that work just like it.
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Reviews & ratings
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Have you used Glyxambi (empaglifozin / linagliptin)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Onglyza (saxagliptin)?
Worth itNot sureNot worth it
Side effects
GlyxambiOnglyza
  • Urinary tract infection 13%
  • Ear, nose, or throat infection 7%
  • Common cold 6%
  • Low blood sugar 2%
More Glyxambi side effects »
  • Urinary tract infection 1%
  • Headache 1%
  • Swelling in arms and legs 4%
  • Low blood sugar (hypoglycemia) 2%
  • Allergic reactions 2%
More Onglyza side effects »
How it works
GlyxambiOnglyza
Glyxambi (empaglifozin / linagliptin) contains 2 anti-diabetes medicines. Empagliflozin lowers blood sugar by increasing secretion of blood sugar into your urine, while linagliptin helps your body produce more insulin and less glucagon.Onglyza (saxagliptin) is an anti-diabetic drug. It lowers your blood sugar by enhancing your body's release of insulin.
Type of medication
GlyxambiOnglyza
Prescription onlyPrescription only
Available as
GlyxambiOnglyza
  • Pill
  • Pill
Used for
GlyxambiOnglyza
Risk factors for serious side effects
GlyxambiOnglyza
  • Kidney problems
  • Liver problems
  • Alcohol use
  • Age 65 or older
  • Surgery
Detailed Glyxambi (empaglifozin / linagliptin) risks & warnings »
  • Alcoholism
  • Elevated triglycerides
  • History of pancreatitis
  • Gallstones
  • History of heart failure
Detailed Onglyza (saxagliptin) risks & warnings »
Pregnancy
Interactions
GlyxambiOnglyza
No interactions related info.
  • Certain drugs may interact with Onglyza (saxagliptin), let your doctor know all the medications you are currently taking and before starting Onglyza (saxagliptin).
Food
GlyxambiOnglyza
  • Take in the morning by mouth with or without food.
No food related info.
Kidneys and liver
GlyxambiOnglyza
  • Rarely, Glyxambi (empaglifozin / linagliptin) can hurt the kidneys. This is more likely to happen if you already have kidney damage, heart failure, or take certain medicines for blood pressure or anti-inflammatories (NSAIDs). Your doctor will check your kidneys by blood tests regularly, and might ask you to change how you take Glyxambi (empaglifozin / linagliptin).
  • May not be good for people who have kidney problems.
  • May be a good option for those with bad liver function.
Weight
GlyxambiOnglyza
  • Can cause weight loss.
  • Does not cause weight gain.
Upsides and benefits
GlyxambiOnglyza
  • Lowers A1c levels by 1.0-1.5%.
  • Can cause weight loss.
  • Taken once daily.
  • Can lower the risk of death in those with underlying heart disease.
  • DRUG-NAME is an oral blood sugar lowering medicine. It's a good option if you don't like injections.
  • Does not cause weight gain.
  • May be a good option for those with bad liver function.
  • Does not cause hypoglycemia (low blood sugar) when taken by itself.
Downsides and risks
GlyxambiOnglyza
  • May not be good for people who have kidney problems.
  • Not available as a generic, so can be more expensive than other diabetes medications.
  • Can increase likelihood of urinary tract or yeast infections.
  • May cause you to urinate more frequently throughout the day.
  • Typically not first-choice treatment for diabetes.
  • Only lowers A1C (average blood sugar over time) by ~0.5%.
  • Risk for heart failure has not been seen in other medicines that work just like it.
  • May be more expensive than other anti-diabetic medicines.
Tips from our pharmacists for people taking the medication
GlyxambiOnglyza
  • Take in the morning by mouth with or without food.
  • Make sure to stay hydrated as Glyxambi (empaglifozin / linagliptin) may cause you to urinate more often.
  • Practice good genital hygiene to reduce likelihood of yeast or urinary tract infections.
  • Check your blood sugar regularly.
  • Let your doctor know of any persistent dizziness, joint pain, cold-like symptoms, repeat yeast infections or urinary infections.
  • Get immediate medical attention if you have unexplained nausea/vomiting.
  • Is taken once daily.
  • Certain drugs may interact with Onglyza (saxagliptin), let your doctor know all the medications you are currently taking and before starting Onglyza (saxagliptin).
  • Stop taking Onglyza (saxagliptin) and see your doctor immediately if you experience severe stomach pain that does not go away, as this may indicate dangerous inflammation of the pancreas.
  • Maintain a consistent diet and exercise regimen to prevent low blood sugar or high blood sugar.
Learn more
More about GlyxambiSide effectsAlternativesFDA package insert
Have you used Glyxambi (empaglifozin / linagliptin)?
Worth itNot sureNot worth it
More about OnglyzaSide effectsAlternativesFDA package insert
Have you used Onglyza (saxagliptin)?
Worth itNot sureNot worth it