Compare Haldol vs. Clozaril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Haldol
(haloperidol)

Clozaril
(clozapine)

Helps control your thoughts and calms agitation. Haldol (Haloperidol) is okay for treating psychosis and agitation. It's less likely to cause weight gain than other antipsychotics, but it's more likely to cause other bad side effects.Helps control your thoughts and actions. Clozaril (Clozapine) treats schizophrenia when other drugs haven't worked, but you'll have to get blood work done regularly and might gain weight.
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Coupons for Haldol
Best available price for 30 (5mg) tablets of haloperidol
Coupons for Clozaril
Best available price for 90 (100mg) tablets of clozapine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.12Haldol
Reviews for Haldol
38%
of people (All ages) say Haldol is worth it
42%
say it works well
34%
say it's a big hassle
Have you used Haldol (haloperidol)?
Worth itNot sureNot worth it

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Have you used Clozaril (clozapine)?
Worth itNot sureNot worth it
Side effects
HaldolClozaril

The Haldol FDA package insert doesn’t have numbers about how common side effects are.

More about Haldol side effects »
  • Drowsiness/sedation 39%
  • Salivation 31%
  • Abnormally fast heart beat 25%
  • Dizziness/vertigo 19%
  • Constipation 14%
  • Low blood pressure 9%
  • Headache 7%
  • Dry mouth 6%
  • Sweating 6%
  • Fainting 6%
More Clozaril side effects »
How it works
HaldolClozaril
Haldol (Haloperidol) is a traditional antipsychotic. Researchers don't know exactly how it works, but it seems to change dopamine activity in your brain, which affects thoughts and mood.Clozaril (Clozapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.
Type of medication
HaldolClozaril
Prescription onlyPrescription only
Available as
HaldolClozaril
  • Pill
  • Liquid
  • Injection
  • Pill
  • Dissolving tablet
  • Liquid
Used for
HaldolClozaril
Risk factors for serious side effects
HaldolClozaril
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Haldol (haloperidol) risks & warnings »
  • Dehydration
  • Taking blood pressure medications
  • Seizure disorder
  • Alcohol abuse
  • History of heart problems
Detailed Clozaril (clozapine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
HaldolClozaril
No alcohol related info.
  • You need to limit the amount of alcohol you drink while on Clozaril (Clozapine).
Food
HaldolClozaril
  • Haldol (Haloperidol) can increase your blood sugar and cholesterol. However, Haldol (Haloperidol) is less likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
No food related info.
Sleep
HaldolClozaril
  • It can cause dizziness, drowsiness, and can lower your blood pressure.
  • Can cause dizziness or drowsiness. Avoid alcohol and be careful when changing positions or doing anything that requires your full attention until you know how it affects you.
Weight
HaldolClozaril
  • Haldol (Haloperidol) can cause you to gain weight. However, Haldol (Haloperidol) is less likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Less likely to cause weight gain and problems with cholesterol and blood sugar than most other antipsychotics.
  • People on Clozaril (Clozapine) have reported weight gain. This is common. If this bothers you, talk to your doctor about what you can do to stop this from happening.
  • Can affect your weight, cholesterol, and blood sugar control.
Upsides and benefits
HaldolClozaril
  • Effective at relieving psychotic symptoms and agitation.
  • Works just as well as other antipsychotic medicines.
  • Less likely to cause weight gain and problems with cholesterol and blood sugar than most other antipsychotics.
  • Clinical studies show that Clozaril (Clozapine) is effective in treating schizophrenia when other medications have failed.
  • Has the lowest risk of causing movement problems when compared to other antipsychotic medicines.
  • Clozaril (Clozapine) is available as a normal tablet and as a mint-flavored tablet that dissolves on the tongue without water.
  • Available as a generic, which is cheaper.
Downsides and risks
HaldolClozaril
  • It's an older medicine and has a lot more side effects than newer antipsychotics.
  • Compared to other antipsychotics, it causes more hormone problems that can cause nipples to leak fluid, and sudden, dangerous abnormal heart rhythms.
  • Has a higher risk of extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements. One of these symptoms (called tardive dyskinesia) is permanent and more likely if you take this medicine for many years.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics have side effects that make them difficult to take. You might need to try a few different medicines until you find one that works best for you.
  • You need to get blood work done every time you can get a prescription filled for Clozaril (Clozapine).
  • You can only get Clozaril (Clozapine) at certain pharmacies that are registered to provide it.
  • If you don't get Clozaril (Clozapine) within 7 days of it being ready at the pharmacy, then you have to get blood work done again and get a new prescription from your doctor.
  • You need to limit the amount of alcohol you drink while on Clozaril (Clozapine).
Tips from our pharmacists for people taking the medication
HaldolClozaril
  • It'll take 4 to 6 weeks to see the medication's full effects on your thoughts.
  • It can cause dizziness, drowsiness, and can lower your blood pressure.
  • For the first week, avoid activities like driving that require you to be alert.
  • Immediately tell your doctor if you can't control your muscle movements or if you have a fever or excess sweating.
  • Don't use in elderly people who have dementia.
  • The oral liquid concentrate can be mixed with water or juice before taking it.
  • Take Clozaril (Clozapine) exactly as prescribed and don't stop taking it without talking to your doctor.
  • Can cause dizziness or drowsiness. Avoid alcohol and be careful when changing positions or doing anything that requires your full attention until you know how it affects you.
  • Blood tests are needed before you start this medicine and before every refill. You need to pick up the medicine within 7 days of your blood tests.
  • Can affect your weight, cholesterol, and blood sugar control.
Learn more
More about HaldolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Haldol (haloperidol)?
Worth itNot sureNot worth it
More about ClozarilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Clozaril (clozapine)?
Worth itNot sureNot worth it