Compare Haldol vs. Clozaril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Haldol (haloperidol)

Prescription only

Clozaril (Clozapine)

Prescription only
Helps control your thoughts, calm agitation, and stabilize your mood.

Haldol (haloperidol) is less likely to cause weight gain and sedation, but more likely to cause movement disorders compared to other antipsychotics.

4.1/ 7 average rating with 50 reviewsforHaldol
Helps control your thoughts and actions.

Clozaril (Clozapine) treats schizophrenia when other drugs haven't worked, but you'll have to get blood work done regularly and might gain weight.

  • Haldol (haloperidol) is available in a cheap, generic version.
  • A monthly extended-release injection allows for more convenient dosing than a daily pill.
  • Clinical studies show that Clozaril (Clozapine) is effective in treating schizophrenia when other medications have failed.
  • Has the lowest risk of causing movement problems when compared to other antipsychotic medicines.
  • Clozaril (Clozapine) is available as a normal tablet and as a mint-flavored tablet that dissolves on the tongue without water.
  • Available as a generic, which is cheaper.
  • Haldol (haloperidol) is an older medicine and has a lot more problematic side effects compared to newer antipsychotics.
  • You might need routine blood tests and regular check-ups to make sure the medicine is working for you.
  • You need to get blood work done every time you can get a prescription filled for Clozaril (Clozapine).
  • You can only get Clozaril (Clozapine) at certain pharmacies that are registered to provide it.
  • If you don't get Clozaril (Clozapine) within 7 days of it being ready at the pharmacy, then you have to get blood work done again and get a new prescription from your doctor.
  • You need to limit the amount of alcohol you drink while on Clozaril (Clozapine).
Used for
Dosage forms
  • Pill
  • Liquid
  • Injection
  • Pill
  • Dissolving tablet
  • Liquid
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Side effects
The Haldol (haloperidol) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Drowsiness/Sedation
  • Salivation
  • Tachycardia
  • Dizziness/Vertigo
  • Constipation
  • Hypotension
  • Headache
  • Tremor
  • Syncope
  • Sweating
See more detailed side effects
Risks and warnings
  • Increased risk of death

    Elderly patients with dementia

  • Heart problems

    History of heart problems

    ...and 1 more risk factors

  • Driving impairment

    Drinking alcohol

    ...and 1 more risk factors

See more detailed risks and warnings
  • Low blood pressure | Slow heartbeat | Fainting


    ...and 1 more risk factors

  • Seizures

    Seizure disorder

    ...and 1 more risk factors

  • Heart problems

    History of heart problems

  • Increased risk of death

    Over 65 and having dementia

  • Increased blood sugar


  • Return of schizophrenic symptoms

    Stopping Clozaril (Clozapine) suddenly

See more detailed risks and warnings