Compare Haldol vs. Invega

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Haldol
(Haloperidol)

Invega
(Paliperidone)

Helps control your thoughts and calms agitation. Haldol (Haloperidol) is okay for treating psychosis and agitation. It's less likely to cause weight gain than other antipsychotics, but it's more likely to cause other bad side effects.Helps control your thoughts and mood. Invega (Paliperidone) is good for treating psychosis and improving mood. It's more likely to cause hormone problems than other antipsychotics.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.081632653061225Haldol
Reviews for Haldol (Haloperidol)
37%
of people say Haldol (Haloperidol) is worth it
41%
say it works well
35%
say it's a big hassle
Reviews for Invega (Paliperidone)
30%
7% vs. Haldol (Haloperidol)
33%
8% vs. Haldol (Haloperidol)
30%
+5% vs. Haldol (Haloperidol)
Side effects
HaldolInvega

The Haldol FDA package insert doesn’t have numbers about how common side effects are.

More about Haldol side effects »
  • Abnormally fast heart beat 7%
  • Anxiety 5%
  • Common cold 4%
  • Indigestion 4%
  • Constipation 3%
  • Positional low blood pressure 3%
  • Muscle weakness 3%
  • Headache 2%
  • Nausea 2%
  • Abdominal discomfort 2%
More Invega side effects »
How it works
HaldolInvega
Haldol (Haloperidol) is a traditional antipsychotic. Researchers don't know exactly how it works, but it seems to change dopamine activity in your brain, which affects thoughts and mood.Invega (Paliperidone) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affect your thoughts and mood.
Type of medication
HaldolInvega
Antipsychotic
Typical
Prescription only
Antipsychotic
Atypical
Prescription only
Available as
HaldolInvega
  • Pill
  • Liquid
  • Injection
  • Extended release
  • Injection
Used for (click to learn more)
HaldolInvega
Risk factors for serious side effects
HaldolInvega
  • Elderly patients with dementia
      • History of heart problems
      • Drug interactions
        • People with diabetes
        • People with high cholesterol
        • People with diabetes
        • Alcohol
        • Taking other medicines that make you less alert
          Detailed Haldol (Haloperidol) risks & warnings »
          • Elderly patients with dementia
              • History of heart problems
              • Drug interactions
                • People with diabetes
                • People with high cholesterol
                • People with diabetes
                • Alcohol
                • Taking other medicines that make you less alert
                  Detailed Invega (Paliperidone) risks & warnings »
                  Pregnancy category
                  HaldolInvega
                  CFDA pregnancy category (Weigh risks vs. benefits)

                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  See the FDA package insert
                  CFDA pregnancy category (Weigh risks vs. benefits)

                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  See the FDA package insert
                  Alcohol
                  No specific alcohol-related info.No specific alcohol-related info.
                  Food
                  • Haldol (Haloperidol) can increase your blood sugar and cholesterol. However, Haldol (Haloperidol) is less likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Haldol (Haloperidol) can cause you to gain weight. However, Haldol (Haloperidol) is less likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Invega (Paliperidone) can increase your blood sugar and cholesterol. Invega (Paliperidone) is moderately likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Invega (Paliperidone) can cause you to gain weight. Invega (Paliperidone) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  Kidneys and liver
                  No specific kidneys and liver-related info.No specific kidneys and liver-related info.
                  Sex
                  No specific sex-related info.No specific sex-related info.
                  Sleep
                  • It can cause dizziness, drowsiness, and can lower your blood pressure.
                  • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
                  Weight
                  • Less likely to cause weight gain and problems with cholesterol and blood sugar than most other antipsychotics.
                  • Haldol (Haloperidol) can cause you to gain weight. However, Haldol (Haloperidol) is less likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Sometimes causes weight gain and low blood pressure.
                  • Invega (Paliperidone) can cause you to gain weight. Invega (Paliperidone) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  Upsides and benefits
                  HaldolInvega
                  • Effective at relieving psychotic symptoms and agitation.
                  • Less likely to cause weight gain and problems with cholesterol and blood sugar than most other antipsychotics.
                  • Works just as well as other antipsychotic medicines.
                  • Effective at relieving psychotic symptoms and relapse rates for people with schizophrenia.
                  • Also relieves psychotic symptoms and improves mood for people with schizoaffective disorder.
                  • Less likely to cause heart or liver problems than some other antipsychotic medications.
                  • Works just as well as other antipsychotic medicines.
                  Downsides and risks
                  HaldolInvega
                  • It's an older medicine and has a lot more side effects than newer antipsychotics.
                  • Compared to other antipsychotics, it causes more hormone problems that can cause nipples to leak fluid, and sudden, dangerous abnormal heart rhythms.
                  • Has a higher risk of extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements. One of these symptoms (called tardive dyskinesia) is permanent and more likely if you take this medicine for many years.
                  • You might need routine blood tests to check how the medicine is affecting your body.
                  • All antipsychotics have side effects that make them difficult to take. You might need to try a few different medicines until you find one that works best for you.
                  • Invega (Paliperidone) has a high risk of causing hormone problems that cause nipples to leak fluid and male breasts to grow abnormally large.
                  • Sometimes causes weight gain and low blood pressure.
                  • Mild risk of causing extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
                  • Not a good choice for elderly people who have dementia.
                  • You might need routine blood tests to check how the medicine is affecting your body.
                  • All antipsychotics have side effects that make them difficult to take. You might need to try a few different medicines until you find one that works best for you.
                  Tips from our pharmacists for people taking the medication
                  HaldolInvega
                  • It'll take 4 to 6 weeks to see the medication's full effects on your thoughts.
                  • It can cause dizziness, drowsiness, and can lower your blood pressure.
                  • Immediately tell your doctor if you can't control your muscle movements or if you have a fever or excess sweating.
                  • Don't use in elderly people who have dementia.
                  • The oral liquid concentrate can be mixed with water or juice before taking it.
                  • For the first week, avoid activities like driving that require you to be alert.
                  • It'll take 4 to 6 weeks to see the medication's full effects on thoughts and mood.
                  • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
                  • Don't worry if you see tablet shells in your stool since the medication was already absorbed by your body.
                  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
                  • Elderly people who have dementia shouldn't take Invega (Paliperidone).
                  • For the first week, avoid activities like driving that require you to be alert.
                  Learn more
                  More about HaldolSide effectsReviews & ratingsAlternativesFDA package insert
                  More about InvegaSide effectsReviews & ratingsAlternativesFDA package insert