Compare Haldol vs. Saphris

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Haldol
(haloperidol)

Saphris
(asenapine)

Helps control your thoughts and calms agitation. Haldol (Haloperidol) is okay for treating psychosis and agitation. It's less likely to cause weight gain than other antipsychotics, but it's more likely to cause other bad side effects.Treats bipolar disorder and schizophrenia. While Saphris (asenapine) has fewer side effects compared with other medicines that treat bipolar disorder and schizophrenia, it can be more expensive.
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Prices and coupon for 30 (5mg) tablets of haloperidol
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Prices and coupon for 30 (10mg) orally disintegrating tabs of asenapine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.12Haldol
Reviews for Haldol (haloperidol)
38%
of people (All ages) say Haldol (haloperidol) is worth it
42%
say it works well
34%
say it's a big hassle
Have you used Haldol (haloperidol)?
Worth itNot sureNot worth it

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Have you used Saphris (asenapine)?
Worth itNot sureNot worth it
Side effects
HaldolSaphris

The Haldol FDA package insert doesn’t have numbers about how common side effects are.

More about Haldol side effects »
  • Trouble sleeping 2%
  • Sleepiness 6%
  • Difficulty controlling movements 3%
  • Restlessness 3%
  • Numbness in the mouth 4%
  • Dizziness 1%
  • Weight gain 2%
More Saphris side effects »
How it works
HaldolSaphris
Haldol (Haloperidol) is a traditional antipsychotic. Researchers don't know exactly how it works, but it seems to change dopamine activity in your brain, which affects thoughts and mood.While it's not clear how Saphris (asenapine) helps to treat bipolar disorder or schizophrenia, it changes the amount of dopamine and serotonin in the brain, two chemicals that are known to regulate mood.
Type of medication
HaldolSaphris
Prescription only
Prescription only
Available as
HaldolSaphris
  • Pill
  • Liquid
  • Injection
  • Dissolving pill
Used for
HaldolSaphris
Risk factors for serious side effects
HaldolSaphris
  • Elderly patients with dementia
      • History of heart problems
      • Drug interactions
        • People with diabetes
        • People with high cholesterol
        • People with diabetes
        • Alcohol
        • Taking other medicines that make you less alert
          Detailed Haldol (haloperidol) risks & warnings »
          • People age 65 or older with dementia and psychosis
          • Taking antipsychotic medications
              • High blood pressure
              • History of heart disease
                Detailed Saphris (asenapine) risks & warnings »
                Pregnancy

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                Food
                HaldolSaphris
                • Haldol (Haloperidol) can increase your blood sugar and cholesterol. However, Haldol (Haloperidol) is less likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                • Haldol (Haloperidol) can cause you to gain weight. However, Haldol (Haloperidol) is less likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                No food related info.
                Sleep
                HaldolSaphris
                • It can cause dizziness, drowsiness, and can lower your blood pressure.
                No sleep related info.
                Weight
                HaldolSaphris
                • Less likely to cause weight gain and problems with cholesterol and blood sugar than most other antipsychotics.
                • Haldol (Haloperidol) can cause you to gain weight. However, Haldol (Haloperidol) is less likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                • People on medicines like Saphris (asenapine) have had weight gain and higher blood sugar to the point of having diabetes. Your doctor will work with you to stop that from happening.
                Upsides and benefits
                HaldolSaphris
                • Effective at relieving psychotic symptoms and agitation.
                • Works just as well as other antipsychotic medicines.
                • Less likely to cause weight gain and problems with cholesterol and blood sugar than most other antipsychotics.
                • Saphris (asenapine) can be used to treat bipolar disorder in children age 10 or older, and schizophrenia in children age 12 or older.
                • You don't need water to take Saphris (asenapine); the pill dissolves in your mouth right away.
                • Compared to other medicines, the side effects of Saphris (asenapine) are milder.
                Downsides and risks
                HaldolSaphris
                • It's an older medicine and has a lot more side effects than newer antipsychotics.
                • Compared to other antipsychotics, it causes more hormone problems that can cause nipples to leak fluid, and sudden, dangerous abnormal heart rhythms.
                • Has a higher risk of extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements. One of these symptoms (called tardive dyskinesia) is permanent and more likely if you take this medicine for many years.
                • You might need routine blood tests to check how the medicine is affecting your body.
                • All antipsychotics have side effects that make them difficult to take. You might need to try a few different medicines until you find one that works best for you.
                • Saphris (asenapine) is only available as a brand name.
                • Compared to other medicines, Saphris (asenapine) can cause changes in your hormones and make you sleepy.
                • You have to take Saphris (asenapine) twice a day, which can be hard to remember.
                Tips from our pharmacists for people taking the medication
                HaldolSaphris
                • It'll take 4 to 6 weeks to see the medication's full effects on your thoughts.
                • It can cause dizziness, drowsiness, and can lower your blood pressure.
                • For the first week, avoid activities like driving that require you to be alert.
                • Immediately tell your doctor if you can't control your muscle movements or if you have a fever or excess sweating.
                • Don't use in elderly people who have dementia.
                • The oral liquid concentrate can be mixed with water or juice before taking it.
                • To take Saphris (asenapine), place the pill under your tongue and let it dissolve completely. Don't chew or swallow the pill, and don't eat or drink for 10 minutes after you take it.
                • You might feel numbness or tingling in your mouth or throat after you take Saphris (asenapine). This usually goes away after an hour.
                • Don't drive or do anything requiring concentration until you know how Saphris (asenapine) affects you.
                • Don't stop taking Saphris (asenapine) suddenly without talking to your doctor first because it can be very dangerous.
                • If you miss a dose of Saphris (asenapine), take it as soon as you remember, unless it’s time for your next dose; don't take 2 doses at the same time.
                • Keep Saphris (asenapine) in your pantry away from heat, moisture, and light. Don't store it in your bathroom's medicine cabinet.
                Learn more
                More about HaldolSide effectsReviews & ratingsAlternativesFDA package insert
                Have you used Haldol (haloperidol)?
                Worth itNot sureNot worth it
                More about SaphrisSide effectsReviews & ratingsAlternativesFDA package insert
                Have you used Saphris (asenapine)?
                Worth itNot sureNot worth it