Compare Haldol vs. Saphris

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Haldol (haloperidol)

Prescription only

Saphris (asenapine)

Prescription only
Helps control your thoughts, calm agitation, and stabilize your mood.

Haldol (haloperidol) is less likely to cause weight gain and sedation, but more likely to cause movement disorders compared to other antipsychotics.

4.1/ 7 average rating with 50 reviewsforHaldol
Treats bipolar disorder and schizophrenia.

While Saphris (asenapine) has fewer side effects compared with other medicines that treat bipolar disorder and schizophrenia, it can be more expensive.

Upsides
  • Haldol (haloperidol) is available in a cheap, generic version.
  • A monthly extended-release injection allows for more convenient dosing than a daily pill.
  • Saphris (asenapine) can be used to treat bipolar disorder in children age 10 or older, and schizophrenia in children age 12 or older.
  • You don't need water to take Saphris (asenapine); the pill dissolves in your mouth right away.
  • Compared to other medicines, the side effects of Saphris (asenapine) are milder.
Downsides
  • Haldol (haloperidol) is an older medicine and has a lot more problematic side effects compared to newer antipsychotics.
  • You might need routine blood tests and regular check-ups to make sure the medicine is working for you.
  • Saphris (asenapine) is only available as a brand name.
  • Compared to other medicines, Saphris (asenapine) can cause changes in your hormones and make you sleepy.
  • You have to take Saphris (asenapine) twice a day, which can be hard to remember.
Used for
Dosage forms
  • Pill
  • Liquid
  • Injection
  • Dissolving pill
Price
Lowest price near you
$4
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Lowest price near you
$568.43
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Reviews
50 
38%
think this treatment is worth it
42%
think this treatment works well
34%
think this treatment is a hassle

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Side effects
The Haldol (haloperidol) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Sleepiness
    22%
  • Trouble sleeping
    10%
  • Difficulty controlling movements
    6%
  • Numbness in the mouth
    5%
  • Fatigue
    4%
  • Dizziness
    4%
  • Indigestion
    3%
  • Swelling in the arms and legs
    3%
  • Weight gain
    3%
  • High blood pressure
    3%
See more detailed side effects
Risks and warnings
  • Increased risk of death

    Elderly patients with dementia

  • Heart problems

    History of heart problems

    ...and 1 more risk factors

  • Driving impairment

    Drinking alcohol

    ...and 1 more risk factors

See more detailed risks and warnings
  • Higher risk of death

    People age 65 or older with dementia and psychosis

  • Neuroleptic malignant syndrome

    Taking antipsychotic medications

  • Changes in blood pressure and fainting

    High blood pressure

    ...and 1 more risk factors

See more detailed risks and warnings