Compare Haldol vs. trifluoperazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Haldol
(haloperidol)

Stelazine
(trifluoperazine)

Helps control your thoughts and calms agitation. Haldol (Haloperidol) is okay for treating psychosis and agitation. It's less likely to cause weight gain than other antipsychotics, but it's more likely to cause other bad side effects.Treats anxiety and schizophrenia. Stelazine (trifluoperazine) can be used to treat schizophrenia, but you might have trouble controlling your movements.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.12Haldol
Reviews for Haldol
38%
of people (All ages) say Haldol is worth it
42%
say it works well
34%
say it's a big hassle
Have you used Haldol (haloperidol)?
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Have you used Stelazine (trifluoperazine)?
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Side effects
Haldoltrifluoperazine

The Haldol FDA package insert doesn’t have numbers about how common side effects are.

More about Haldol side effects »

The trifluoperazine FDA package insert doesn’t have numbers about how common side effects are.

More about trifluoperazine side effects »
How it works
Haldoltrifluoperazine
Haldol (Haloperidol) is a traditional antipsychotic. Researchers don't know exactly how it works, but it seems to change dopamine activity in your brain, which affects thoughts and mood.Stelazine (trifluoperazine) is a first generation (typical) antipsychotic. It works in schizophrenia by making the brain less sensitive to changes in dopamine, which helps regulate your mood.
Type of medication
Haldoltrifluoperazine
Prescription onlyPrescription only
Available as
Haldoltrifluoperazine
  • Pill
  • Liquid
  • Injection
  • Pill
Used for
Haldoltrifluoperazine
Risk factors for serious side effects
Haldoltrifluoperazine
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Haldol (haloperidol) risks & warnings »
  • People age 65 and older with dementia and psychosis
  • Women age 65 and older
  • Taking antipsychotic medications
  • History of low white or red blood cell counts
Detailed Stelazine (trifluoperazine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
Haldoltrifluoperazine
No alcohol related info.
  • Don't drink alcohol while taking Stelazine (trifluoperazine).
Food
Haldoltrifluoperazine
  • Haldol (Haloperidol) can increase your blood sugar and cholesterol. However, Haldol (Haloperidol) is less likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
No food related info.
Sleep
Haldoltrifluoperazine
  • It can cause dizziness, drowsiness, and can lower your blood pressure.
No sleep related info.
Weight
Haldoltrifluoperazine
  • Haldol (Haloperidol) can cause you to gain weight. However, Haldol (Haloperidol) is less likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Less likely to cause weight gain and problems with cholesterol and blood sugar than most other antipsychotics.
No weight related info.
Upsides and benefits
Haldoltrifluoperazine
  • Effective at relieving psychotic symptoms and agitation.
  • Works just as well as other antipsychotic medicines.
  • Less likely to cause weight gain and problems with cholesterol and blood sugar than most other antipsychotics.
  • Stelazine (trifluoperazine) is one of the recommended medicines for schizophrenia.
  • It’s approved in children age 6 and older.
  • Available in generic.
  • Compared to other similar medicines, you're less likely to feel dehydrated or have problems with your heart with Stelazine (trifluoperazine).
Downsides and risks
Haldoltrifluoperazine
  • It's an older medicine and has a lot more side effects than newer antipsychotics.
  • Compared to other antipsychotics, it causes more hormone problems that can cause nipples to leak fluid, and sudden, dangerous abnormal heart rhythms.
  • Has a higher risk of extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements. One of these symptoms (called tardive dyskinesia) is permanent and more likely if you take this medicine for many years.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics have side effects that make them difficult to take. You might need to try a few different medicines until you find one that works best for you.
  • If you take Stelazine (trifluoperazine) for more than 12 weeks or are taking high doses of Stelazine (trifluoperazine), you’re at a higher risk for being unable to control your movements.
  • Stelazine (trifluoperazine) can cause agitation and trouble sleeping. These symptoms can sometimes disappear, or there are other treatments you can take to help.
Tips from our pharmacists for people taking the medication
Haldoltrifluoperazine
  • It'll take 4 to 6 weeks to see the medication's full effects on your thoughts.
  • It can cause dizziness, drowsiness, and can lower your blood pressure.
  • For the first week, avoid activities like driving that require you to be alert.
  • Immediately tell your doctor if you can't control your muscle movements or if you have a fever or excess sweating.
  • Don't use in elderly people who have dementia.
  • The oral liquid concentrate can be mixed with water or juice before taking it.
  • Stelazine (trifluoperazine) can make you more sensitive to changes in temperature. If it's hot out, drink plenty of liquids, don't exercise too hard, and protect yourself from the sun. If it's cold, dress warm and don't stay outside too long.
  • Stelazine (trifluoperazine) can make you feel sleepy for the first few days. Don't drive or do anything requiring concentration until you know how it affects you.
  • Don't drink alcohol while taking Stelazine (trifluoperazine).
  • You might feel dizzy or faint the first few days you take Stelazine (trifluoperazine). Be very careful getting up if you've been sitting or lying down for a while.
  • If you want to stop taking Stelazine (trifluoperazine) and you've been taking it for at least a few months, talk to your doctor first.
Learn more
More about HaldolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Haldol (haloperidol)?
Worth itNot sureNot worth it
More about trifluoperazineSide effectsAlternativesFDA package insert
Have you used Stelazine (trifluoperazine)?
Worth itNot sureNot worth it