Compare Haldol vs. Zyprexa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Haldol
(Haloperidol)

Zyprexa
(Olanzapine)

Helps control your thoughts and calms agitation. Haldol (Haloperidol) is okay for treating psychosis and agitation. It's less likely to cause weight gain than other antipsychotics, but it's more likely to cause other bad side effects.Helps control your thoughts and mood. Zyprexa (Olanzapine) is good for treating psychosis, mania, and agitation. More likely to cause weight gain and sleepiness than other antipsychotics.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.081632653061225Haldol
Reviews for Haldol (Haloperidol)
37%
of people say Haldol (Haloperidol) is worth it
41%
say it works well
35%
say it's a big hassle
Reviews for Zyprexa (Olanzapine)
45%
+8% vs. Haldol (Haloperidol)
53%
+12% vs. Haldol (Haloperidol)
47%
12% vs. Haldol (Haloperidol)
Side effects
HaldolZyprexa

The Haldol FDA package insert doesn’t have numbers about how common side effects are.

More about Haldol side effects »
  • Relaxation or sleepiness 39%
  • Increased appetite 25%
  • Weight increase 22%
  • Drowsiness 22%
  • Dry mouth 15%
  • Dizziness 12%
  • Muscle weakness 9%
  • Fatigue 8%
  • Constipation 6%
  • Indigestion 6%
More Zyprexa side effects »
How it works
HaldolZyprexa
Haldol (Haloperidol) is a traditional antipsychotic. Researchers don't know exactly how it works, but it seems to change dopamine activity in your brain, which affects thoughts and mood.Zyprexa (Olanzapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.
Type of medication
HaldolZyprexa
Antipsychotic
Typical
Prescription only
Antipsychotic
Atypical
Prescription only
Available as
HaldolZyprexa
  • Pill
  • Liquid
  • Injection
  • Pill
  • Dissolving tablet
  • Injection
Used for (click to learn more)
HaldolZyprexa
Risk factors for serious side effects
HaldolZyprexa
  • Elderly patients with dementia
      • History of heart problems
      • Drug interactions
        • People with diabetes
        • People with high cholesterol
        • People with diabetes
        • Alcohol
        • Taking other medicines that make you less alert
          Detailed Haldol (Haloperidol) risks & warnings »
          • Elderly patients with dementia
              • History of heart problems
              • Drug interactions
                • People with diabetes
                • People with high cholesterol
                • People with diabetes
                • Alcohol
                • Taking other medicines that make you less alert
                  Detailed Zyprexa (Olanzapine) risks & warnings »
                  Pregnancy category
                  HaldolZyprexa
                  CFDA pregnancy category (Weigh risks vs. benefits)

                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  See the FDA package insert
                  CFDA pregnancy category (Weigh risks vs. benefits)

                  Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                  See the FDA package insert
                  Alcohol
                  No specific alcohol-related info.No specific alcohol-related info.
                  Food
                  • Haldol (Haloperidol) can increase your blood sugar and cholesterol. However, Haldol (Haloperidol) is less likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Haldol (Haloperidol) can cause you to gain weight. However, Haldol (Haloperidol) is less likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Zyprexa (Olanzapine) can increase your blood sugar and cholesterol. Zyprexa (Olanzapine) is more likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  Kidneys and liver
                  No specific kidneys and liver-related info.No specific kidneys and liver-related info.
                  Sex
                  No specific sex-related info.No specific sex-related info.
                  Sleep
                  • It can cause dizziness, drowsiness, and can lower your blood pressure.
                  • Can cause dizziness and drowsiness.
                  Weight
                  • Less likely to cause weight gain and problems with cholesterol and blood sugar than most other antipsychotics.
                  • Haldol (Haloperidol) can cause you to gain weight. However, Haldol (Haloperidol) is less likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
                  • May cause weight gain and worsen cholesterol or blood sugar.
                  • Zyprexa (Olanzapine) can cause you to gain weight. Zyprexa (Olanzapine) is more likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                  Upsides and benefits
                  HaldolZyprexa
                  • Effective at relieving psychotic symptoms and agitation.
                  • Works just as well as other antipsychotic medicines.
                  • Less likely to cause weight gain and problems with cholesterol and blood sugar than most other antipsychotics.
                  • Effective at relieving psychotic symptoms, manic episodes, and agitation in people with schizophrenia and bipolar disorder.
                  • Lowers relapse rates for schizophrenia and bipolar disorder.
                  • Antipsychotic medicines are all about equally effective.
                  • Less likely to cause heart problems than some antipsychotics.
                  Downsides and risks
                  HaldolZyprexa
                  • It's an older medicine and has a lot more side effects than newer antipsychotics.
                  • Compared to other antipsychotics, it causes more hormone problems that can cause nipples to leak fluid, and sudden, dangerous abnormal heart rhythms.
                  • Has a higher risk of extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements. One of these symptoms (called tardive dyskinesia) is permanent and more likely if you take this medicine for many years.
                  • All antipsychotics have side effects that make them difficult to take. You might need to try a few different medicines until you find one that works best for you.
                  • You might need routine blood tests to check how the medicine is affecting your body.
                  • More likely to cause weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
                  • Might make you more sleepy than some antipsychotics.
                  • Mild risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
                  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
                  • You might need routine blood tests to check how the medicine is affecting your body.
                  Tips from our pharmacists for people taking the medication
                  HaldolZyprexa
                  • It'll take 4 to 6 weeks to see the medication's full effects on your thoughts.
                  • It can cause dizziness, drowsiness, and can lower your blood pressure.
                  • For the first week, avoid activities like driving that require you to be alert.
                  • Immediately tell your doctor if you can't control your muscle movements or if you have a fever or excess sweating.
                  • Don't use in elderly people who have dementia.
                  • The oral liquid concentrate can be mixed with water or juice before taking it.
                  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
                  • Can cause dizziness and drowsiness.
                  • For the first week, avoid activities that require you to be alert.
                  • May cause weight gain and worsen cholesterol or blood sugar.
                  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
                  • Elderly people with dementia shouldn't take it.
                  Learn more
                  More about HaldolSide effectsReviews & ratingsAlternativesFDA package insert
                  More about ZyprexaSide effectsReviews & ratingsAlternativesFDA package insert