Compare Horizant vs. Lyrica

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Horizant
(gabapentin enacarbil)

Lyrica
(pregabalin)

Calms leg movements and nerve pain. Horizant (Gabapentin Enacarbil) is a good way to treat pain since it can be used with other pain medications and it's not addictive. You'll need to stop drinking alcohol and it can be somewhat expensive.Treats nerve pain and prevents seizures. Lyrica (Pregabalin) works well as an add-on medicine for seizures and fibromyalgia, but it's especially effective for nerve-related pain after shingles. Not available as a generic, so it might be expensive.
Reviews & ratings
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Have you used Horizant (gabapentin enacarbil)?
Worth itNot sureNot worth it
Reviews for Lyrica
47%
+53% better vs. Horizant
42%
+50% better vs. Horizant
32%
+32% better vs. Horizant
Have you used Lyrica (pregabalin)?
Worth itNot sureNot worth it
Side effects
HorizantLyrica
  • Somnolence/sedation 14%
  • Dizziness 9%
  • Headache 1%
  • Nausea 1%
  • Fatigue 2%
  • Irritability 3%
  • Dry mouth 1%
  • Passing gas 3%
  • Increased appetite 2%
More Horizant side effects »
  • Nerve damage 6%
  • Dizziness 3%
  • Lack of muscle coordination 5%
  • Accidental injury 2%
  • Chest pain 3%
  • Leg or ankle swelling 2%
  • Muscle weakness 2%
  • Drowsiness 1%
  • Passing gas 2%
  • Dry mouth 2%
More Lyrica side effects »
How it works
HorizantLyrica
Horizant (Gabapentin Enacarbil) treats restless leg syndrome and pain caused by shingles by lowering your body's response to pain. It's used for long-lasting (chronic) pain and doesn't work for sudden (acute) pain.Lyrica (Pregabalin) is a nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.
Type of medication
HorizantLyrica
Prescription onlyPrescription only
Available as
HorizantLyrica
  • Pill
  • Pill
  • Liquid
Used for
HorizantLyrica
Risk factors for serious side effects
HorizantLyrica
  • Stopping Horizant (Gabapentin Enacarbil) suddenly
Detailed Horizant (gabapentin enacarbil) risks & warnings »
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • History of unusual swelling (angioedema)
  • Taking other medications that can angioedema
  • History of cardiovascular disease
Detailed Lyrica (pregabalin) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Price
HorizantLyrica
No price related info.
  • Not available as a generic, so it can be pricey.
Alcohol
HorizantLyrica
  • Need to avoid alcohol while on Horizant (Gabapentin Enacarbil).
  • It's not safe to take this medication with alcohol or other drugs that make you drowsy.
Food
HorizantLyrica
  • Swallow the pills whole and take with food.
  • Has to be taken with food.
No food related info.
Pain
HorizantLyrica
  • Can be used with other pain medications.
  • Has a higher risk than other pain medicines of affecting your heart rate or rhythm, so it might not be the best choice if you have cardiovascular disease (previous heart attack, stroke, fast/uncontrolled heart rate, or irregular heartbeat).
Sleep
HorizantLyrica
  • Horizant (Gabapentin Enacarbil) can make you feel dizzy or sleepy for the first few days or weeks that you take it. Until your body has adjusted to the medication, be very careful getting up from sitting or lying down, and don't drive or use machinery.
  • Can make you drowsy or dizzy.
  • Lyrica (Pregabalin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, and confusion.
Upsides and benefits
HorizantLyrica
  • Not habit-forming or addictive.
  • Can be used with other pain medications.
  • Only has to be taken once or twice a day.
  • Relieves nerve-related (neuropathic) pain caused by different conditions including diabetes, shingles (herpes zoster), fibromyalgia, and spinal cord damage.
  • Studies show that lower doses of Lyrica (Pregabalin) cause fewer side effects and still relieve pain just as well as higher doses.
  • Also used in combination with other medications to treat epilepsy (partial seizures).
Downsides and risks
HorizantLyrica
  • Need to avoid alcohol while on Horizant (Gabapentin Enacarbil).
  • Has to be taken with food.
  • If you want to stop taking this medication, you need to talk to your doctor first since stopping it cold turkey can cause seizures.
  • Not available as a generic.
  • Not available as a generic, so it can be pricey.
  • You can't skip or miss doses since suddenly stopping Lyrica (Pregabalin) can cause seizures.
  • Lyrica (Pregabalin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, and confusion.
  • Has a higher risk than other pain medicines of affecting your heart rate or rhythm, so it might not be the best choice if you have cardiovascular disease (previous heart attack, stroke, fast/uncontrolled heart rate, or irregular heartbeat).
Tips from our pharmacists for people taking the medication
HorizantLyrica
  • Don't stop taking Horizant (Gabapentin Enacarbil) suddenly without telling your doctor.
  • Can make you feel dizzy or drowsy the first few days or weeks that you're taking it.
  • Swallow the pills whole and take with food.
  • Horizant (Gabapentin Enacarbil) is different from other forms of gabapentin (like Neurontin), so these two medications can't be switched or substituted for each other.
  • Some people feel relief from pain in a week.
  • Can make you drowsy or dizzy.
  • Don't stop taking it suddenly without talking to your doctor. You'll need to slowly lower your dose over at least a week to avoid withdrawal symptoms.
  • Tell your doctor if you have unexplained confusion or changes in your thoughts or behavior.
  • It's not safe to take this medication with alcohol or other drugs that make you drowsy.
Learn more
More about HorizantSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Horizant (gabapentin enacarbil)?
Worth itNot sureNot worth it
More about LyricaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lyrica (pregabalin)?
Worth itNot sureNot worth it