Compare Horizant vs. Lyrica

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Horizant (Gabapentin Enacarbil)

Prescription only

Lyrica (pregabalin)

Prescription only
Calms leg movements and nerve pain.

Horizant (Gabapentin Enacarbil) is a good way to treat pain since it can be used with other pain medications and it's not addictive. You'll need to stop drinking alcohol and it can be somewhat expensive.

Treats pain caused by nerve damage and prevents seizures.

Lyrica (pregabalin) is first-choice treatment for nerve pain, but may be expensive since it is available as brand name only.

4.4/ 7 average rating with 66 reviewsforLyrica
  • Not habit-forming or addictive.
  • Can be used with other pain medications.
  • Only has to be taken once or twice a day.
  • Unlike other pain relievers, it is very effective at treating and preventing nerve damage caused by diabetes, shingles, fibromyalgial, and spinal cord injuries.
  • It is less habit forming than narcotics.
  • It can also be used in combination with other anti-seizure medicines to treat epilepsy.
  • Need to avoid alcohol while on Horizant (Gabapentin Enacarbil).
  • Has to be taken with food.
  • If you want to stop taking this medication, you need to talk to your doctor first since stopping it cold turkey can cause seizures.
  • Not available as a generic.
  • Likely expensive since it is not available in generic versions.
  • Has a higher risk than other pain medicines to affect your heart rate or rhythm.
  • Requires adjustment in dose if you have lower kidney function.
  • Higher doses can cause drowsiness so you will have to divide the dose and take it throughout the day.
Used for
Dosage forms
  • Pill
  • Pill
  • Liquid
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Side effects
The Horizant (Gabapentin Enacarbil) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Dizziness
  • Drowsiness
  • Headache
  • Blurry vision
  • Weight gain
  • Dry mouth
  • Fatigue
  • Swelling of the hands and feet
  • Constipation
  • Sinus infection
See more detailed side effects
Risks and warnings
  • Seizures

    Stopping Horizant (Gabapentin Enacarbil) suddenly

See more detailed risks and warnings
  • Suicidal thoughts or behavior

    Starting Lyrica (pregabalin) or changing doses

  • Driving impairment

    Taking Lyrica (pregabalin) with alcohol

    ...and 1 more risk factors

  • Giant hives (angioedema)

    History of unusual swelling (angioedema)

    ...and 1 more risk factors

  • Heart problems

    History of cardiovascular disease

  • Swelling of the hands and feet

    Taking with certain diabetes medications

  • Withdrawal symptoms

    Stopping Lyrica (pregabalin) suddenly

See more detailed risks and warnings