Compare Horizant vs. Neurontin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Horizant (Gabapentin Enacarbil)

Prescription only

Neurontin (gabapentin)

Prescription only
Calms leg movements and nerve pain.

Horizant (Gabapentin Enacarbil) is a good way to treat pain since it can be used with other pain medications and it's not addictive. You'll need to stop drinking alcohol and it can be somewhat expensive.

Treats tingling and burning nerve pain.

Neurontin (gabapentin) is an old seizure disorder medicine that is now used to treat nerve-related pain caused by different conditions.

4.6/ 7 average rating with 620 reviewsforNeurontin
Upsides
  • Not habit-forming or addictive.
  • Can be used with other pain medications.
  • Only has to be taken once or twice a day.
  • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
  • It's available as a generic, so it's less expensive than similar medications.
Downsides
  • Need to avoid alcohol while on Horizant (Gabapentin Enacarbil).
  • Has to be taken with food.
  • If you want to stop taking this medication, you need to talk to your doctor first since stopping it cold turkey can cause seizures.
  • Not available as a generic.
  • Neurontin (gabapentin) can cause some side effects, including memory problems, drowsiness, dizziness, or confusion. There is a higher risk for these side effects if you drink alcohol, so it might not be the best medication for heavy drinkers.
  • You can't skip or miss doses since suddenly stopping Neurontin (gabapentin) can cause seizures.
Used for
Dosage forms
  • Pill
  • Pill
  • Oral solution
  • Extended release
Price
Lowest price near you
$378.3
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Lowest price near you
$12.05
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Reviews
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620 
57%
think this treatment is worth it
40%
think this treatment works well
19%
think this treatment is a hassle

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Side effects
The Horizant (Gabapentin Enacarbil) FDA package insert doesn’t have numbers about how common side effects are.
The Neurontin (gabapentin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Seizures

    Stopping Horizant (Gabapentin Enacarbil) suddenly

See more detailed risks and warnings
  • Neurologic and psychiatric side effects (children)

    Children ages 3 to 12

  • Driving impairment

    Taking Neurontin (gabapentin) with alcohol

    ...and 1 more risk factors

  • Withdrawal seizures

    Stopping Neurontin (gabapentin) suddenly

See more detailed risks and warnings