Compare Horizant vs. Pamelor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Calms leg movements and nerve pain.

Horizant (Gabapentin Enacarbil) is a good way to treat pain since it can be used with other pain medications and it's not addictive. You'll need to stop drinking alcohol and it can be somewhat expensive.

Improves your mood.

Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.

4.0/ 5 average rating with 19 reviewsforPamelor
Upsides
  • Not habit-forming or addictive.
  • Can be used with other pain medications.
  • Only has to be taken once or twice a day.
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
Downsides
  • Need to avoid alcohol while on Horizant (Gabapentin Enacarbil).
  • Has to be taken with food.
  • If you want to stop taking this medication, you need to talk to your doctor first since stopping it cold turkey can cause seizures.
  • Not available as a generic.
  • Side effects are usually manageable, but can be annoying.
  • Increases the risk of falls, especially when used in the elderly.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
Used for
Dosage forms
  • Pill
  • Pill
  • Liquid
Price
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Reviews
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19 reviews so far
79%
saidit'sworth it
79%
saiditworked well
21%
saidit'sa big hassle

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Side effects
The Horizant (Gabapentin Enacarbil) FDA package insert doesn’t have numbers about how common side effects are.
The Pamelor (Nortriptyline) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Effects on driving
  • Dizziness | Sleepiness
  • Changes in mood
  • Rash
  • Seizures
    • Stopping Horizant (Gabapentin Enacarbil) suddenly
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Low blood pressure
    • Age 65 years or older
  • Withdrawal
    • Stopping Pamelor (Nortriptyline) suddenly
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • Heart problems
    • History of heart disease
    • Older age
    • Electrolyte imbalance
See more detailed risks and warnings