Compare Horizant vs. Pamelor

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(Gabapentin Enacarbil)


Calms leg movements and nerve pain. Horizant (Gabapentin Enacarbil) is a good way to treat pain since it can be used with other pain medications and it's not addictive. You'll need to stop drinking alcohol and it can be somewhat expensive.Improves your mood. Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.
How it works
Horizant (Gabapentin Enacarbil) treats restless leg syndrome and pain caused by shingles by lowering your body's response to pain. It's used for long-lasting (chronic) pain and doesn't work for sudden (acute) pain.Pamelor (Nortriptyline) is a tricyclic antidepressant (TCA). It helps improve your mood by altering the levels of serotonin, norepinephrine, and other similar chemicals in your brain.
Type of medication
Pain reliever
GABA analog
Prescription only
Tricyclic antidepressant (TCA)
Prescription only
Available as
  • Pill
  • Pill
  • Liquid
Used for (click to learn more)
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Reviews & ratings
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Side effects
  • Somnolence/sedation 21%
  • Dizziness 15%
  • Fatigue/weaknesse/asthenia 9%
  • Drowsiness 6%
  • Sleep difficulty 5%
  • Weight increased 4%
  • Headache 4%
  • Nausea 4%
  • Fatigue 3%
  • Irritability 3%
More Horizant side effects »

We haven’t found good data for Pamelor side effects.

FDA side effect reports for Pamelor »
Risk factors for serious side effects
          • Stopping Horizant (Gabapentin Enacarbil) suddenly
          Detailed Horizant (Gabapentin Enacarbil) risks & warnings »
          • Age 24 years or younger
          • Age 65 years or older
          • Stopping Pamelor (Nortriptyline) suddenly
          • Using other medications that affect serotonin
          • History of heart disease
          • Older age
          • Electrolyte imbalance
          Detailed Pamelor (Nortriptyline) risks & warnings »
          Pregnancy category
          • Need to avoid alcohol while on Horizant (Gabapentin Enacarbil).
          No specific alcohol-related info.
          • Has to be taken with food.
          • Swallow the pills whole and take with food.
          • Take it with food and/or at bedtime to decrease the potential side effects.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          No specific sex-related info.No specific sex-related info.
          No specific sleep-related info.
          • Stopping Pamelor (Nortriptyline) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and dizziness. Withdrawal symptoms usually occur within 3-5 days of stopping the medication, and go away within 1-2 weeks. Work with your doctor to gradually reduce your dose.
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          • Not habit-forming or addictive.
          • Can be used with other pain medications.
          • Only has to be taken once or twice a day.
          • Helpful with treating certain types of pain, like migraines or nerve-related pain.
          • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
          Downsides and risks
          • Need to avoid alcohol while on Horizant (Gabapentin Enacarbil).
          • Has to be taken with food.
          • If you want to stop taking this medication, you need to talk to your doctor first since stopping it cold turkey can cause seizures.
          • Not available as a generic.
          • Side effects are usually manageable, but can be annoying.
          • Increases the risk of falls, especially when used in the elderly.
          • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
          Tips from our pharmacists for people taking the medication
          • Don't stop taking Horizant (Gabapentin Enacarbil) suddenly without telling your doctor.
          • Can make you feel dizzy or drowsy the first few days or weeks that you're taking it.
          • Swallow the pills whole and take with food.
          • Horizant (Gabapentin Enacarbil) is different from other forms of gabapentin (like Neurontin), so these two medications can't be switched or substituted for each other.
          • Needs to be taken every day for 1 to 2 weeks to start feeling better, and for 6 to 8 weeks to see the full effect of the medication.
          • It's important to keep taking Pamelor (Nortriptyline) even when you feel your symptoms are getting better.
          • Take it with food and/or at bedtime to decrease the potential side effects.
          • Tell your doctor if you notice sudden mood changes or unusual thoughts.
          • If you decide to stop taking Pamelor (Nortriptyline), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
          Learn more
          More about HorizantSide effectsReviews & ratingsAlternativesFDA package insert
          More about PamelorSide effectsReviews & ratingsAlternativesFDA package insert