Compare Horizant vs. Pamelor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Horizant
(gabapentin enacarbil)

Pamelor
(nortriptyline)

Calms leg movements and nerve pain. Horizant (Gabapentin Enacarbil) is a good way to treat pain since it can be used with other pain medications and it's not addictive. You'll need to stop drinking alcohol and it can be somewhat expensive.Improves your mood. Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.
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Coupons for Pamelor
Best available price for 30 (10mg) capsules of nortriptyline
Reviews & ratings
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Reviews for Horizant (gabapentin enacarbil)
Not enough review data. Review it!
of people (All ages) say Horizant (gabapentin enacarbil) is worth it
Not enough review data. Review it!
say it works well
Not enough review data. Review it!
say it's a big hassle
Have you used Horizant (gabapentin enacarbil)?
Worth itNot sureNot worth it
Reviews for Pamelor (nortriptyline)
79%
-21% worse vs. Horizant (gabapentin enacarbil)
79%
-13% worse vs. Horizant (gabapentin enacarbil)
21%
-21% worse vs. Horizant (gabapentin enacarbil)
Have you used Pamelor (nortriptyline)?
Worth itNot sureNot worth it
Side effects
HorizantPamelor
  • Somnolence/sedation 14%
  • Dizziness 9%
  • Headache 1%
  • Nausea 1%
  • Fatigue 2%
  • Irritability 3%
  • Dry mouth 1%
  • Passing gas 3%
  • Increased appetite 2%
More Horizant side effects »

We haven’t found good data for Pamelor side effects.

FDA side effect reports for Pamelor »
How it works
HorizantPamelor
Horizant (Gabapentin Enacarbil) treats restless leg syndrome and pain caused by shingles by lowering your body's response to pain. It's used for long-lasting (chronic) pain and doesn't work for sudden (acute) pain.Pamelor (Nortriptyline) is a tricyclic antidepressant (TCA). It helps improve your mood by altering the levels of serotonin, norepinephrine, and other similar chemicals in your brain.
Type of medication
HorizantPamelor
Prescription only
Prescription only
Available as
HorizantPamelor
  • Pill
  • Pill
  • Liquid
Used for
HorizantPamelor
Risk factors for serious side effects
HorizantPamelor
  • Stopping Horizant (Gabapentin Enacarbil) suddenly
Detailed Horizant (gabapentin enacarbil) risks & warnings »
  • Age 24 years or younger
  • Age 65 years or older
  • Stopping Pamelor (Nortriptyline) suddenly
  • Using other medications that affect serotonin
  • History of heart disease
Detailed Pamelor (nortriptyline) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
HorizantPamelor
  • Need to avoid alcohol while on Horizant (Gabapentin Enacarbil).
No alcohol related info.
Food
HorizantPamelor
  • Has to be taken with food.
  • Swallow the pills whole and take with food.
  • Take it with food and/or at bedtime to decrease the potential side effects.
Pain
HorizantPamelor
  • Can be used with other pain medications.
No pain related info.
Sleep
HorizantPamelor
  • Horizant (Gabapentin Enacarbil) can make you feel dizzy or sleepy for the first few days or weeks that you take it. Until your body has adjusted to the medication, be very careful getting up from sitting or lying down, and don't drive or use machinery.
No sleep related info.
Upsides and benefits
HorizantPamelor
  • Not habit-forming or addictive.
  • Can be used with other pain medications.
  • Only has to be taken once or twice a day.
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
Downsides and risks
HorizantPamelor
  • Need to avoid alcohol while on Horizant (Gabapentin Enacarbil).
  • Has to be taken with food.
  • If you want to stop taking this medication, you need to talk to your doctor first since stopping it cold turkey can cause seizures.
  • Not available as a generic.
  • Side effects are usually manageable, but can be annoying.
  • Increases the risk of falls, especially when used in the elderly.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
Tips from our pharmacists for people taking the medication
HorizantPamelor
  • Don't stop taking Horizant (Gabapentin Enacarbil) suddenly without telling your doctor.
  • Can make you feel dizzy or drowsy the first few days or weeks that you're taking it.
  • Swallow the pills whole and take with food.
  • Horizant (Gabapentin Enacarbil) is different from other forms of gabapentin (like Neurontin), so these two medications can't be switched or substituted for each other.
  • Needs to be taken every day for 1 to 2 weeks to start feeling better, and for 6 to 8 weeks to see the full effect of the medication.
  • It's important to keep taking Pamelor (Nortriptyline) even when you feel your symptoms are getting better.
  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • If you decide to stop taking Pamelor (Nortriptyline), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
Learn more
More about HorizantSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Horizant (gabapentin enacarbil)?
Worth itNot sureNot worth it
More about PamelorSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Pamelor (nortriptyline)?
Worth itNot sureNot worth it