Compare Humalog vs. Apidra

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Humalog
(Insulin Lispro)

Apidra
(Insulin Glulisine)

Lowers blood sugar. Humalog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Coming soon.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.060931899641577Humalog
Reviews for Humalog (Insulin Lispro)
64%
of people say Humalog (Insulin Lispro) is worth it
49%
say it works well
16%
say it's a big hassle

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Side effects
HumalogApidra

The Humalog FDA package insert doesn’t have numbers about how common side effects are.

More about Humalog side effects »

We haven’t found good data for Apidra side effects.

FDA side effect reports for Apidra »
How it works
HumalogApidra
Humalog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.Coming soon.
Type of medication
HumalogApidra
Anti-diabetic
Insulin
Prescription only
Coming soon.
Available as
HumalogApidra
  • Injection
  • Injection
Used for (click to learn more)
HumalogApidra
  • Diabetes mellitus type 1 Diabetes mellitus type 2
Risk factors for serious side effects
HumalogApidra
  • Insulin dose too high
  • Use of other blood sugar lowering medicines
  • Poor injection techniques
  • Unstable kidney functions
  • Unstable liver functions
  • Use of other medicine that lowers potassium
  • Current electrolyte imbalance
    Detailed Humalog (Insulin Lispro) risks & warnings »
    Coming soon.
    Pregnancy category
    HumalogApidra
    BFDA pregnancy category (Probably safe)

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.
    Food
    • You have to check your blood sugar multiple times every day, usually before each meal.
    • Humalog is a fast-acting insulin that provides sugar control after meals.
    • Short-acting insulin good for blood sugar control around meal times.
    • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
    No specific food-related info.
    Kidneys and liver
    • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
    No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.No specific sleep-related info.
    Weight
    • Likely to cause moderate weight gain (around 4 to 6 pounds).
    • Can cause weight gain and low blood sugar.
    No specific weight-related info.
    Upsides and benefits
    HumalogApidra
    • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
    • Humalog is a fast-acting insulin that provides sugar control after meals.
    • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
    • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
    • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
    Coming soon.
    Downsides and risks
    HumalogApidra
    • You have to take insulin by injection.
    • You have to check your blood sugar multiple times every day, usually before each meal.
    • Likely to cause moderate weight gain (around 4 to 6 pounds).
    • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
    Coming soon.
    Tips from our pharmacists for people taking the medication
    HumalogApidra
    • Short-acting insulin good for blood sugar control around meal times.
    • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
    • Can cause weight gain and low blood sugar.
    • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
    • Always have a good source of sugar nearby for low blood sugar episodes.
    • Make sure you understand how to give yourself the injections.
    • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
    • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
    • Check your blood sugar levels every day.
    Coming soon.
    Learn more
    More about HumalogSide effectsReviews & ratingsAlternativesFDA package insert
    More about ApidraSide effectsReviews & ratingsFDA package insert