Compare Humalog vs. Glucotrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Humalog
(Insulin Lispro)

Glucotrol
(Glipizide)

Lowers blood sugar. Humalog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Glucotrol (Glipizide) is a very effective oral blood sugar-lowering medicine. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.060931899641577Humalog
Reviews for Humalog (Insulin Lispro)
64%
of people say Humalog (Insulin Lispro) is worth it
49%
say it works well
16%
say it's a big hassle
Reviews for Glucotrol (Glipizide)
50%
14% vs. Humalog (Insulin Lispro)
32%
17% vs. Humalog (Insulin Lispro)
19%
3% vs. Humalog (Insulin Lispro)
Side effects
HumalogGlucotrol

The Humalog FDA package insert doesn’t have numbers about how common side effects are.

More about Humalog side effects »
  • Passing gas 2%
  • Dizziness 1%
  • Nervousness 1%
More Glucotrol side effects »
How it works
HumalogGlucotrol
Humalog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.Glucotrol (Glipizide) is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.
Type of medication
HumalogGlucotrol
Anti-diabetic
Insulin
Prescription only
Anti-diabetic
Sulfonylurea
Prescription only
Available as
HumalogGlucotrol
  • Injection
  • Pill
  • Extended release
Used for (click to learn more)
HumalogGlucotrol
Risk factors for serious side effects
HumalogGlucotrol
  • Insulin dose too high
  • Use of other blood sugar lowering medicines
  • Poor injection techniques
  • Unstable kidney functions
  • Unstable liver functions
  • Use of other medicine that lowers potassium
  • Current electrolyte imbalance
    Detailed Humalog (Insulin Lispro) risks & warnings »
      • Use of other blood sugar lowering medicines
      • Alcohol
      • Intense physical activity
      • History of sulfa allergies
      Detailed Glucotrol (Glipizide) risks & warnings »
      Pregnancy category
      HumalogGlucotrol
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.
      • Avoid drinking alcohol.
      Food
      • You have to check your blood sugar multiple times every day, usually before each meal.
      • Humalog is a fast-acting insulin that provides sugar control after meals.
      • Short-acting insulin good for blood sugar control around meal times.
      • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
      • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
      • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
      • Eat regular, balanced meals to avoid low blood sugar.
      Kidneys and liver
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • Can cause weight gain and low blood sugar.
      • Can cause mild weight gain (2 to 3 pounds).
      • Can cause weight gain, dizziness, or stomach upset.
      Upsides and benefits
      HumalogGlucotrol
      • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
      • Humalog is a fast-acting insulin that provides sugar control after meals.
      • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
      • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      • Oral blood sugar-lowering medicine.
      • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
      • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
      • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
      • One of the least expensive diabetes medicines.
      Downsides and risks
      HumalogGlucotrol
      • You have to take insulin by injection.
      • You have to check your blood sugar multiple times every day, usually before each meal.
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
      • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
      • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
      • Can cause mild weight gain (2 to 3 pounds).
      • Loses effectiveness over time or as your body stops making insulin.
      • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
      Tips from our pharmacists for people taking the medication
      HumalogGlucotrol
      • Short-acting insulin good for blood sugar control around meal times.
      • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
      • Can cause weight gain and low blood sugar.
      • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
      • Always have a good source of sugar nearby for low blood sugar episodes.
      • Make sure you understand how to give yourself the injections.
      • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
      • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
      • Check your blood sugar levels every day.
      • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
      • Can cause weight gain, dizziness, or stomach upset.
      • Avoid drinking alcohol.
      • Eat regular, balanced meals to avoid low blood sugar.
      • Check your blood sugar regularly.
      Learn more
      More about HumalogSide effectsReviews & ratingsAlternativesFDA package insert
      More about GlucotrolSide effectsReviews & ratingsAlternativesFDA package insert