Compare Humalog vs. Glucotrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Humalog
(Insulin Lispro)

Glucotrol
(glipizide)

Lowers blood sugar. Humalog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Glucotrol (glipizide) is an effective medicine for lowering blood sugar, but it can cause your blood sugar level to be too low so you must always carry some form of sugar with you that can be readily used.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.07Humalog
Reviews for Humalog
64%
of people (All ages) say Humalog is worth it
50%
say it works well
16%
say it's a big hassle
280 reviews
Have you used Humalog (Insulin Lispro)?
Worth itNot sureNot worth it
Reviews for Glucotrol
50%
+14% better vs. Humalog
32%
+18% better vs. Humalog
19%
+3% better vs. Humalog
332 reviews
Have you used Glucotrol (glipizide)?
Worth itNot sureNot worth it
Side effects
HumalogGlucotrol
  • Nausea 6%
  • Surgical procedure 6%
  • Fever 6%
  • Dysmenorrhea 6%
  • Urinary tract infection 6%
  • Abdominal pain 7%
  • Asthenia 7%
  • Bronchitis 7%
  • Myalgia 7%
  • Accidental injury 9%
More Humalog side effects »
  • Passing gas 2%
  • Low blood sugar 3%
  • Nervousness 1%
  • Tremor 4%
  • Diarrhea 5%
  • Dizziness 1%
  • Headache 2%
  • Constipation 3%
  • Nausea 3%
More Glucotrol side effects »
How it works
HumalogGlucotrol
Humalog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.Glucotrol (glipizide) stimulates your body to release insulin and lower blood sugar.
Type of medication
HumalogGlucotrol
Prescription onlyNo lower cost generic availablePrescription onlyLower-cost generic available
Available as
HumalogGlucotrol
  • Injection
  • Pill
  • Extended release pill
Used for
HumalogGlucotrol
Risk factors for serious side effects
HumalogGlucotrol
  • Insulin dose too high
  • Use of other blood sugar lowering medicines
  • Poor injection techniques
  • Unstable kidney functions
  • Unstable liver functions
Detailed Humalog (Insulin Lispro) risks & warnings »
  • Skipping meals or having inconsistent meal times
  • Drinking alcohol
  • Using other blood sugar-lowering medicine
  • People age 60 or older
  • Those with kidney and/or liver problems
Detailed Glucotrol (glipizide) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
HumalogGlucotrol
No alcohol related info.
  • Avoid drinking alcohol while taking Glucotrol (glipizide).
Food
HumalogGlucotrol
  • Short-acting insulin good for blood sugar control around meal times.
  • Eat regular and well-balanced meals to keep your blood sugar levels normal.
Kidneys and liver
HumalogGlucotrol
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
No kidneys and liver related info.
Weight
HumalogGlucotrol
  • Can cause weight gain and low blood sugar.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
  • Can cause mild weight gain of 2-3lb.
Upsides and benefits
HumalogGlucotrol
  • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
  • Humalog is a fast-acting insulin that provides sugar control after meals.
  • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
  • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
  • Lowers A1c levels by 1-2%.
  • Glucotrol (glipizide) is an oral medicine so it might be a good alternative for those who don't like injections.
  • Protects your organs and blood vessels by preventing the harmful effects of high blood sugar levels.
  • Okay to use by people with kidney problems.
  • Available as a generic form and is relatively cheap.
Downsides and risks
HumalogGlucotrol
  • You have to take insulin by injection.
  • You have to check your blood sugar multiple times every day, usually before each meal.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
  • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • While taking Glucotrol (glipizide), your blood sugars should be checked 2 to 5 times a week, but less often once you are on a stable dose.
  • Can cause mild weight gain of 2-3lb.
  • Might lose its effectiveness over time.
  • Needs to be taken 30 minutes before a meal for it to be most effective.
Tips from our pharmacists for people taking the medication
HumalogGlucotrol
  • Short-acting insulin good for blood sugar control around meal times.
  • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
  • Can cause weight gain and low blood sugar.
  • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
  • Always have a good source of sugar nearby for low blood sugar episodes.
  • Make sure you understand how to give yourself the injections.
  • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
  • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
  • Check your blood sugar levels every day.
  • Take the medicine 30 minutes before eating, usually before your first big meal of the day.
  • Avoid drinking alcohol while taking Glucotrol (glipizide).
  • Eat regular and well-balanced meals to keep your blood sugar levels normal.
  • Check your blood sugar regularly.
  • Glucotrol (glipizide) can cause dizziness so avoid activities that require coordination until you know how your body can handle the medicine.
Learn more
More about HumalogSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Humalog (Insulin Lispro)?
Worth itNot sureNot worth it
More about GlucotrolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Glucotrol (glipizide)?
Worth itNot sureNot worth it