Compare Humalog vs. glyburide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Humalog (insulin lispro)

Prescription only

Diabeta (glyburide)

Prescription only
Lowers blood sugar.

Humalog (insulin lispro) is a fast-acting insulin that controls blood sugar around meal times.

3.7/ 5 average rating with 280 reviewsforHumalog
Lowers blood sugar.

Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.

3.3/ 5 average rating with 110 reviewsforglyburide
Upsides
  • Humalog (insulin lispro) is the most effective medication for lowering your blood sugar.
  • Works quickly to control your sugar levels after meals.
  • Dose can be easily adjusted to create a regimen that's tailored to your body's needs.
  • Humalog (insulin lispro) can be used even if you have liver or kidney problems, unlike other anti-diabetic medications.
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
Downsides
  • You have to take Humalog (insulin lispro) by injection.
  • Humalog (insulin lispro) is likely to cause moderate weight gain (around 4 to 6 pounds).
  • There is a higher risk for episodes of low blood sugar compared to other anti-diabetic medications.
  • Effects do not last long enough to control your blood sugar for a whole day.
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
Used for
Dosage forms
  • Injection
  • Pill
Price
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Reviews
280 reviews so far
64%
saidit'sworth it
50%
saiditworked well
16%
saidit'sa big hassle

Have you used Humalog (insulin lispro)?

Leave a review
110 reviews so far
45%
saidit'sworth it
34%
saiditworked well
21%
saidit'sa big hassle

Have you used Diabeta (glyburide)?

Leave a review
Side effects
The Humalog (insulin lispro) FDA package insert doesn’t have numbers about how common side effects are.
The Diabeta (glyburide) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Life-threatening low blood sugar (hypoglycemia)
    • Insulin dose too high
    • Use of other blood sugar lowering medications
    • Poor injection techniques
  • Complications due to low potassium
    • Use of medications that lower potassium
    • Current electrolyte imbalance
  • Severe allergic reactions
    • Allergy to insulin
See more detailed risks and warnings
  • Low blood sugar
    • Over age 65
    • Kidney problems
    • Use of other blood sugar lowering medicines
    • Alcohol
    • Intense physical activity
  • Severe allergic reactions
    • History of sulfa allergies
See more detailed risks and warnings