Compare Humalog vs. Novolog

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Humalog
(insulin lispro)

Novolog
(insulin aspart)

Lowers blood sugar. Humalog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Novolog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.07Humalog
Reviews for Humalog (insulin lispro)
64%
of people (All ages) say Humalog (insulin lispro) is worth it
50%
say it works well
16%
say it's a big hassle
280 reviews
Have you used Humalog (insulin lispro)?
Worth itNot sureNot worth it
Reviews for Novolog (insulin aspart)
58%
-6% worse vs. Humalog (insulin lispro)
46%
-4% worse vs. Humalog (insulin lispro)
19%
-3% worse vs. Humalog (insulin lispro)
177 reviews
Have you used Novolog (insulin aspart)?
Worth itNot sureNot worth it
Side effects
HumalogNovolog
  • Flu syndrome 35%
  • Sore throat 33%
  • Headache 30%
  • Inflammation inside the nose 25%
  • Pain 20%
  • Cough increased 17%
  • Infection 14%
  • Accidental injury 9%
  • Diarrhea 9%
  • Muscle weakness 7%
More Humalog side effects »
  • Decreased muscle reflexes 11%
  • Nail fungal infection 10%
  • Abnormal sense of touch 9%
  • Urinary tract infection 8%
  • Chest pain 5%
  • Headache 5%
  • Skin disorder 5%
  • Abdominal pain 5%
  • Sinus inflammation 5%
  • Injury accidental 11%
More Novolog side effects »
How it works
HumalogNovolog
Humalog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.Novolog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.
Type of medication
HumalogNovolog
Prescription only
Prescription only
Available as
HumalogNovolog
  • Injection
  • Injection
Used for
HumalogNovolog
Risk factors for serious side effects
HumalogNovolog
  • Insulin dose too high
  • Use of other blood sugar lowering medicines
  • Poor injection techniques
  • Unstable kidney functions
  • Unstable liver functions
  • Use of other medicine that lowers potassium
  • Current electrolyte imbalance
    Detailed Humalog (insulin lispro) risks & warnings »
    • Insulin dose too high
    • Use of other blood sugar lowering medicines
    • Poor injection techniques
    • Unstable kidney functions
    • Unstable liver functions
    • Use of other medicine that lowers potassium
    • Current electrolyte imbalance
      Detailed Novolog (insulin aspart) risks & warnings »
      Pregnancy

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Food
      HumalogNovolog
      • Short-acting insulin good for blood sugar control around meal times.
      • Novolog is a fast-acting insulin that provides sugar control after meals.
      • Short-acting insulin good for blood sugar control around meal times.
      Kidneys and liver
      HumalogNovolog
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      Weight
      HumalogNovolog
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • Can cause weight gain and low blood sugar.
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • Can cause weight gain and low blood sugar.
      Upsides and benefits
      HumalogNovolog
      • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
      • Humalog is a fast-acting insulin that provides sugar control after meals.
      • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
      • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
      • Novolog is a fast-acting insulin that provides sugar control after meals.
      • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
      • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      Downsides and risks
      HumalogNovolog
      • You have to take insulin by injection.
      • You have to check your blood sugar multiple times every day, usually before each meal.
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
      • You have to take insulin by injection.
      • You have to check your blood sugar multiple times every day, usually before each meal.
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
      Tips from our pharmacists for people taking the medication
      HumalogNovolog
      • Short-acting insulin good for blood sugar control around meal times.
      • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
      • Can cause weight gain and low blood sugar.
      • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
      • Always have a good source of sugar nearby for low blood sugar episodes.
      • Make sure you understand how to give yourself the injections.
      • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
      • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
      • Check your blood sugar levels every day.
      • Short-acting insulin good for blood sugar control around meal times.
      • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
      • Can cause weight gain and low blood sugar.
      • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
      • Always have a good source of sugar nearby for low blood sugar episodes.
      • Make sure you understand how to give yourself the injections.
      • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
      • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
      • Check your blood sugar levels every day.
      Learn more
      More about HumalogSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Humalog (insulin lispro)?
      Worth itNot sureNot worth it
      More about NovologSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Novolog (insulin aspart)?
      Worth itNot sureNot worth it