Compare Human Insulin vs. Apidra

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Humulin
(human insulin)

Apidra
(insulin glulisine)

Lowers blood sugar. This form of insulin is one of the few medications in its class that you can get without a prescription, but it's expensive.Controls blood sugar. Apidra (insulin glulisine) is an insulin that controls blood sugar during your meals, but you'll still have to follow your doctor's diet and exercise plan.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.95Human Insulin
Reviews for Human Insulin
67%
of people (All ages) say Human Insulin is worth it
46%
say it works well
11%
say it's a big hassle
Have you used Humulin (human insulin)?
Worth itNot sureNot worth it

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Have you used Apidra (insulin glulisine)?
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Side effects
Human InsulinApidra

The Human Insulin FDA package insert doesn’t have numbers about how common side effects are.

More about Human Insulin side effects »
  • Common cold 11%
  • Upper respiratory tract infection 8%
  • Low blood sugar 7%
  • Headache 7%
  • Seizure due to low blood sugar 6%
  • Flu 4%
  • Swelling in the arms and legs 8%
  • Joint pain 6%
  • High blood pressure 4%
  • Allergic reactions 4%
More Apidra side effects »
How it works
Human InsulinApidra
Insulin is a hormone normally produced by your pancreas. It helps your body absorb and store sugar and fat from your bloodstream.Apidra (insulin glulisine) is an insulin that controls your blood sugar by turning the sugars you eat into energy or storing it in your body for future use.
Type of medication
Human InsulinApidra
Prescription onlyPrescription only
Available as
Human InsulinApidra
  • Injection
  • Inhaler
  • Injection
Used for
Human InsulinApidra
Risk factors for serious side effects
Human InsulinApidra
    Detailed Humulin (human insulin) risks & warnings »
    • Changes in diet and exercise
    • Drinking alcohol
    • Taking other medications for diabetes
    • Over age 65
    • Liver or kidney problems
    Detailed Apidra (insulin glulisine) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Food
    Human InsulinApidra
    No food related info.
    • Apidra (insulin glulisine) has to be injected with every meal.
    Kidneys and liver
    Human InsulinApidra
    No kidneys and liver related info.
    • Your doctor might have to check your kidneys and liver regularly if you've had kidney or liver problems in the past.
    Weight
    Human InsulinApidra
    • People on Humulin (Human Insulin) can experience weight gain. Talk to your doctor or dietitian about changing your diet if this bothers you.
    No weight related info.
    Upsides and benefits
    Human InsulinApidra
    • Some types of this medication are available without a prescription.
    • Available as a shot to be injected into the fatty part of the skin, and as a powder to be inhaled through your nose.
    • Available in different combinations so that you can do one shot or multiple shots a day.
    • Apidra (insulin glulisine) starts working in as soon as 15 minutes.
    • Programs are available to lower your copay. Talk to your doctor or pharmacist.
    • Can be used in children 4 years of age and older.
    • Can be used in people over 65.
    Downsides and risks
    Human InsulinApidra
    • Has to be taken exactly as directed or it can cause high or low blood sugar.
    • As with all insulins, you have to work with your doctor closely to make sure you're giving yourself the correct dose, or you can have low or high blood sugar.
    • Your doctor might have to check your kidneys and liver regularly if you've had kidney or liver problems in the past.
    • Apidra (insulin glulisine) has to be injected with every meal.
    • Only available as a brand name, so Apidra (insulin glulisine) can be expensive.
    Tips from our pharmacists for people taking the medication
    Human InsulinApidra
    • Change the location where you give yourself the shot every time.
    • Don't use if the liquid in the vial looks different than normal.
    • Store the unopened vials in the refrigerator. The used vials can be kept at room temperature for up to 28 days.
    • Take the medication exactly how your doctor tells you to.
    • Know the symptoms of low blood sugar.
    • Starts working within 10 to 30 minutes, and lasts for up to 5 hours.
    • Take Apidra (insulin glulisine) 15 minutes before a meal or within 20 minutes after starting a meal.
    • Don't mix Apidra (insulin glulisine) for under the skin injection with any other insulin except Novolin N or Humulin N. Don't mix Apidra (insulin glulisine) with any other insulin if you're using an insulin pump.
    • Don't use Apidra (insulin glulisine) if it looks cloudy or changes color, it's leaking or if there are particles in it.
    • Change the area where you inject Apidra (insulin glulisine) every time.
    • Keep all unopened vials or pens of Apidra (insulin glulisine) in the fridge until you're ready to use it. You can keep opened vials and pens at room temperature, but throw it away after 28 days.
    Learn more
    More about Human InsulinSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Humulin (human insulin)?
    Worth itNot sureNot worth it
    More about ApidraSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Apidra (insulin glulisine)?
    Worth itNot sureNot worth it