Compare Human Insulin vs. glyburide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Humulin
(human insulin)

Diabeta
(glyburide)

Lowers blood sugar. This form of insulin is one of the few medications in its class that you can get without a prescription, but it's expensive.Lowers blood sugar. Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.95Human Insulin
Reviews for Human Insulin
67%
of people (All ages) say Human Insulin is worth it
46%
say it works well
11%
say it's a big hassle
Have you used Humulin (human insulin)?
Worth itNot sureNot worth it
Reviews for glyburide
45%
+22% better vs. Human Insulin
34%
+12% better vs. Human Insulin
21%
+10% better vs. Human Insulin
110 reviews
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
Side effects
Human Insulinglyburide

The Human Insulin FDA package insert doesn’t have numbers about how common side effects are.

More about Human Insulin side effects »
  • Nausea and heartburn 2%
  • Skin allergies 2%
More glyburide side effects »
How it works
Human Insulinglyburide
Insulin is a hormone normally produced by your pancreas. It helps your body absorb and store sugar and fat from your bloodstream.Diabeta (glyburide) stimulates your body to release insulin and lower blood sugar.
Type of medication
Human Insulinglyburide
Prescription onlyPrescription only
Available as
Human Insulinglyburide
  • Injection
  • Inhaler
  • Pill
Used for
Human Insulinglyburide
Risk factors for serious side effects
Human Insulinglyburide
    Detailed Humulin (human insulin) risks & warnings »
    • Over age 65
    • Kidney problems
    • Use of other blood sugar lowering medicines
    • Alcohol
    • Intense physical activity
    Detailed Diabeta (glyburide) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Alcohol
    Human Insulinglyburide
    No alcohol related info.
    • Try to avoid drinking alcohol while on Diabeta (glyburide).
    Food
    Human Insulinglyburide
    No food related info.
    • Eat well-balanced meals to avoid low blood sugar.
    Kidneys and liver
    Human Insulinglyburide
    No kidneys and liver related info.
    • Not ideal for elderly or those with poor kidney function.
    Weight
    Human Insulinglyburide
    • People on Humulin (Human Insulin) can experience weight gain. Talk to your doctor or dietitian about changing your diet if this bothers you.
    • Can cause weight gain, dizziness, or stomach upset.
    • Can cause weight gain (about 2 to 3 pounds).
    Upsides and benefits
    Human Insulinglyburide
    • Some types of this medication are available without a prescription.
    • Available as a shot to be injected into the fatty part of the skin, and as a powder to be inhaled through your nose.
    • Available in different combinations so that you can do one shot or multiple shots a day.
    • Available as an oral tablet.
    • Lowers your A1c (average blood sugar over time) up to 2%.
    • Available in generic version.
    • Available in single pill combination with other anti-diabetic medicines.
    Downsides and risks
    Human Insulinglyburide
    • Has to be taken exactly as directed or it can cause high or low blood sugar.
    • As with all insulins, you have to work with your doctor closely to make sure you're giving yourself the correct dose, or you can have low or high blood sugar.
    • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
    • You will have to check your blood sugar often when you first start taking it.
    • Can cause weight gain (about 2 to 3 pounds).
    • Not ideal for elderly or those with poor kidney function.
    • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
    Tips from our pharmacists for people taking the medication
    Human Insulinglyburide
    • Change the location where you give yourself the shot every time.
    • Don't use if the liquid in the vial looks different than normal.
    • Store the unopened vials in the refrigerator. The used vials can be kept at room temperature for up to 28 days.
    • Take the medication exactly how your doctor tells you to.
    • Know the symptoms of low blood sugar.
    • Check your blood sugar regularly.
    • Eat well-balanced meals to avoid low blood sugar.
    • Works best if you take it 30 minutes before first main meal of the day.
    • Can cause weight gain, dizziness, or stomach upset.
    • Try to avoid drinking alcohol while on Diabeta (glyburide).
    Learn more
    More about Human InsulinSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Humulin (human insulin)?
    Worth itNot sureNot worth it
    More about glyburideSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Diabeta (glyburide)?
    Worth itNot sureNot worth it