Human insulin vs. Janumet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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(Human Insulin)

(Sitagliptin / Metformin)

Lowers blood sugar. This form of insulin is one of the few medications in its class that you can get without a prescription, but it's expensive.Lowers blood sugar. Janumet is an expensive but very effective combination of oral blood sugar-lowering medicines.
How it works
Insulin is a hormone normally produced by your pancreas. It helps your body absorb and store sugar and fat from your bloodstream.Janumet is an antidiabetic combination medicine. Metformin lowers the amount of sugar your body produces, and sitagliptin helps your body release more insulin.
Type of medication
Prescription only
DPP-4 inhibitor
Prescription only
Available as
  • Injection
  • Inhaler
  • Pill
  • Extended release
Used for (click to learn more)
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.947368421052632Human insulin
Reviews for Humulin (Human Insulin)
of people say Humulin (Human Insulin) is worth it
say it works well
say it's a big hassle
Reviews for Janumet (Sitagliptin / Metformin)
-23% vs. Humulin (Human Insulin)
-10% vs. Humulin (Human Insulin)
-5% vs. Humulin (Human Insulin)
Side effects

The Human insulin FDA package insert doesn’t have numbers about how common side effects are.

More about Human insulin side effects »
  • Diarrhea 4%
  • Nausea 4%
  • Headache 3%
  • Abdominal pain 1%
  • Ear, nose, or throat infection 1%
More Janumet side effects »
Risk factors for serious side effects
        Detailed Humulin (Human Insulin) risks & warnings »
        • Kidney problems
        • Liver problems
        • Congestive heart failure
        • Contrast dye for procedure
        • Surgery
        • Alcohol use
              Detailed Janumet (Sitagliptin / Metformin) risks & warnings »
              Pregnancy category
              BFDA pregnancy category (Probably safe)

              Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

              See the FDA package insert
              BFDA pregnancy category (Probably safe)

              Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

              See the FDA package insert
              No specific alcohol-related info.No specific alcohol-related info.
              No specific food-related info.
              • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
              Kidneys and liver
              No specific kidneys and liver-related info.
              • People with poor kidney function can't use it.
              • Janumet (Sitagliptin / Metformin) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Janumet (Sitagliptin / Metformin). It may not be a good choice for people with kidney problems. Janumet (Sitagliptin / Metformin) should be stopped 48 hours before and/or after surgery or any imaging procedure needing contrast dye.
              No specific sex-related info.No specific sex-related info.
              No specific sleep-related info.No specific sleep-related info.
              • People on Humulin (Human Insulin) can experience weight gain. Talk to your doctor or dietitian about changing your diet if this bothers you.
              • Doesn't cause weight gain or low blood sugar.
              Upsides and benefits
              • Some types of this medication are available without a prescription.
              • Available as a shot to be injected into the fatty part of the skin, and as a powder to be inhaled through your nose.
              • Available in different combinations so that you can do one shot or multiple shots a day.
              • 2-in-1 combination medicine. If you need more than one blood sugar medicine, this lowers the number of pills you have to take.
              • Lowers A1c levels by 1-2.5%. (Hemoglobin A1c measures your average blood sugar over time.)
              • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
              • Doesn't cause weight gain or low blood sugar.
              • You don't have to check your blood sugar every day with this medicine.
              Downsides and risks
              • Has to be taken exactly as directed or it can cause high or low blood sugar.
              • As with all insulins, you have to work with your doctor closely to make sure you're giving yourself the correct dose, or you can have low or high blood sugar.
              • Likely expensive since there's no generic version available.
              • The metformin part of Janumet can cause nausea, indigestion, or diarrhea for most people in the first few weeks.
              • People with poor kidney function can't use it.
              • The sitagliptin part of Janumet can cause some people to have frequent throat infections or nasal congestion.
              • Might raise the risk of problems with your pancreas.
              Tips from our pharmacists for people taking the medication
              • Change the location where you give yourself the shot every time.
              • Don't use if the liquid in the vial looks different than normal.
              • Store the unopened vials in the refrigerator. The used vials can be kept at room temperature for up to 28 days.
              • Take the medication exactly how your doctor tells you to.
              • Know the symptoms of low blood sugar.
              • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
              • May cause headaches and cold-like symptoms.
              • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
              • Can be expensive depending on insurance coverage.
              • Check your blood sugar regularly.
              Learn more
              More about Human insulinSide effectsReviews & ratingsAlternativesFDA package insert
              More about JanumetSide effectsReviews & ratingsAlternativesFDA package insert