Compare Human Insulin vs. Januvia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Humulin
(human insulin)

Januvia
(sitagliptin)

Lowers blood sugar. This form of insulin is one of the few medications in its class that you can get without a prescription, but it's expensive.Lowers your blood sugar. Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.
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Coupons for Human Insulin
Best available price for 1 (five 3ml kwikpens of 100 units/ml) carton of humulin-n
Coupons for Januvia
Best available price for 30 (100mg) tablets of januvia
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.95Human Insulin
Reviews for Human Insulin
67%
of people (All ages) say Human Insulin is worth it
46%
say it works well
11%
say it's a big hassle
Have you used Humulin (human insulin)?
Worth itNot sureNot worth it
Reviews for Januvia
44%
+23% better vs. Human Insulin
34%
+12% better vs. Human Insulin
17%
+6% better vs. Human Insulin
143 reviews
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it
Side effects
Human InsulinJanuvia

The Human Insulin FDA package insert doesn’t have numbers about how common side effects are.

More about Human Insulin side effects »
  • Common cold 2%
  • Diarrhea 1%
  • Upper respiratory infection 3%
  • Headache 1%
More Januvia side effects »
How it works
Human InsulinJanuvia
Insulin is a hormone normally produced by your pancreas. It helps your body absorb and store sugar and fat from your bloodstream.Januvia (sitagliptin) is an anti-diabetic drug that enhances your body's release of insulin.
Type of medication
Human InsulinJanuvia
Prescription onlyPrescription only
Available as
Human InsulinJanuvia
  • Injection
  • Inhaler
  • Pill
Used for
Human InsulinJanuvia
Risk factors for serious side effects
Human InsulinJanuvia
    Detailed Humulin (human insulin) risks & warnings »
    • History of pancreatitis
    • High blood triglyceride levels
    • Gallstones (stones in gallbladder)
    • History of alchoholism
    • Kidney problems
    Detailed Januvia (sitagliptin) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Food
    Human InsulinJanuvia
    No food related info.
    • Take once a day in the morning with or without food.
    Kidneys and liver
    Human InsulinJanuvia
    No kidneys and liver related info.
    • Januvia (sitagliptin) can worsen kidney problems. Your doctor may check your kidney function before and during treatment. Your doctor may have to adjust the dose or stop this medicine based on changes in kidney function.
    Pain
    Human InsulinJanuvia
    No pain related info.
    • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
    Weight
    Human InsulinJanuvia
    • People on Humulin (Human Insulin) can experience weight gain. Talk to your doctor or dietitian about changing your diet if this bothers you.
    • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
    Upsides and benefits
    Human InsulinJanuvia
    • Some types of this medication are available without a prescription.
    • Available as a shot to be injected into the fatty part of the skin, and as a powder to be inhaled through your nose.
    • Available in different combinations so that you can do one shot or multiple shots a day.
    • Oral blood sugar-lowering medicine.
    • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
    • Uses the hormones naturally produced by your body to affect how sugar is processed.
    • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
    Downsides and risks
    Human InsulinJanuvia
    • Has to be taken exactly as directed or it can cause high or low blood sugar.
    • As with all insulins, you have to work with your doctor closely to make sure you're giving yourself the correct dose, or you can have low or high blood sugar.
    • Lowers A1c (average blood sugar over time) by less than 1%.
    • Available as brand version only.
    • Some people might get frequent cold-like symptoms.
    • Rare but serious side effects include pancreatitis and severe joint pain.
    Tips from our pharmacists for people taking the medication
    Human InsulinJanuvia
    • Change the location where you give yourself the shot every time.
    • Don't use if the liquid in the vial looks different than normal.
    • Store the unopened vials in the refrigerator. The used vials can be kept at room temperature for up to 28 days.
    • Take the medication exactly how your doctor tells you to.
    • Know the symptoms of low blood sugar.
    • Take once a day in the morning with or without food.
    • Can cause headache and cold-like symptoms.
    • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
    • Tell your doctor right away if you are experiencing severe joint pain.
    • Check your blood sugar regularly to check for low blood sugar.
    Learn more
    More about Human InsulinSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Humulin (human insulin)?
    Worth itNot sureNot worth it
    More about JanuviaSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Januvia (sitagliptin)?
    Worth itNot sureNot worth it