Compare Humira vs. Arava

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Humira
(adalimumab)

Arava
(leflunomide)

Calms down the immune system. Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects.Coming soon.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for Humira
Best available price for 2 (2 pens of 40mg/0.8ml) cartons of humira
Coupons for Arava
Best available price for 30 (20mg) tablets of arava
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.94Humira
Reviews for Humira
60%
of people (All ages) say Humira is worth it
51%
say it works well
26%
say it's a big hassle
182 reviews
Have you used Humira (adalimumab)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Arava (leflunomide)?
Worth itNot sureNot worth it
Side effects
HumiraArava
  • Upper airway infection 4%
  • Rash 6%
  • Headache 4%
  • Sinus infection 2%
  • Nausea 1%
  • Injection site reactions 7%
  • Urinary tract infection 3%
  • Flu syndrome 1%
  • Stomach pain 3%
  • High cholesterol 2%
More Humira side effects »

We haven’t found good data for Arava side effects.

FDA side effect reports for Arava »
How it works
HumiraArava
Humira (adalimumab) is a TNF blocker which stops inflammation.Coming soon.
Type of medication
HumiraArava
Prescription only
Available as
HumiraArava
  • Injection
  • Pill
Used for
HumiraArava
  • Rheumatoid Arthritis
Risk factors for serious side effects
HumiraArava
  • Taking other immunosuppressant medications such as Kineret or Orencia
  • Age 65 or older
  • Active, chronic, or recurrent infection
  • Comorbidities
  • Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Humira (adalimumab)
Detailed Humira (adalimumab) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Upsides and benefits
    HumiraArava
    • Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
    • You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
    • Humira (adalimumab) treats many different autoimmune conditions.
    • Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
    Coming soon
    Downsides and risks
    HumiraArava
    • Not first-choice treatment for rheumatoid arthritis.
    • Humira (adalimumab) is an injection and not an oral medication.
    • Humira (adalimumab) is expensive because there's no generic available yet.
    • Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
    • You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
    • Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
    Coming soon
    Tips from our pharmacists for people taking the medication
    HumiraArava
    • Humira (adalimumab) is a medication that's injected under the skin. Your doctor can give you your first dose, then you can inject yourself at home once you feel comfortable doing so on your own.
    • Humira (adalimumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
    • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
    • Each time you use Humira (adalimumab), it's important to rotate the sites you chose to inject it in. Don't inject Humira (adalimumab) into skin that's red, bruised, or irritated.
    • As with all injection medicines, store securely away from children and throw away used syringes in an FDA-approved sharps disposal container, and not in the trash.
    Coming soon
    Learn more
    More about HumiraSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Humira (adalimumab)?
    Worth itNot sureNot worth it
    More about AravaSide effectsReviews & ratingsFDA package insert
    Have you used Arava (leflunomide)?
    Worth itNot sureNot worth it