Compare Humira vs. Cimzia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Humira
(adalimumab)

Cimzia
(certolizumab)

Calms down the immune system. Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects.Reduces inflammation. Cimzia (Certolizumab) is an effective medicine to calm down your immune system, but it can be expensive and it requires a lot of monitoring while you're taking it.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for Humira
Best available price for 1 (2 pens of 40mg/0.8ml) carton of adalimumab
Coupons for Cimzia
Best available price for 1 (starter of 200mg/ml) kit of certolizumab
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.94Humira
Reviews for Humira (adalimumab)
60%
of people (All ages) say Humira (adalimumab) is worth it
51%
say it works well
26%
say it's a big hassle
182 reviews
Have you used Humira (adalimumab)?
Worth itNot sureNot worth it
Reviews for Cimzia (certolizumab)
Not enough review data. Review it!
+7% better vs. Humira (adalimumab)
Not enough review data. Review it!
+7% better vs. Humira (adalimumab)
Not enough review data. Review it!
+26% better vs. Humira (adalimumab)
Have you used Cimzia (certolizumab)?
Worth itNot sureNot worth it
Side effects
HumiraCimzia
  • Upper airway infection 4%
  • Rash 6%
  • Headache 4%
  • Sinus infection 2%
  • Nausea 1%
  • Injection site reactions 7%
  • Urinary tract infection 3%
  • Flu syndrome 1%
  • Stomach pain 3%
  • High cholesterol 2%
More Humira side effects »
  • Any side effect 1%
  • Upper respiratory infections 7%
  • Urinary tract infections 1%
  • Joint pain 2%
  • Ear, nose, or throat infection 4%
  • Headache 1%
  • High blood pressure 3%
  • Common cold 4%
  • Back pain 3%
  • Fever 1%
More Cimzia side effects »
How it works
HumiraCimzia
Humira (adalimumab) is a TNF blocker which stops inflammation.Cimzia (Certolizumab) is a monoclonal antibody. It lowers inflammation in the body by blocking a protein called TNF (tumor necrosis factor).
Type of medication
HumiraCimzia
Prescription only
Prescription only
Available as
HumiraCimzia
  • Injection
  • Injection
Used for
HumiraCimzia
Risk factors for serious side effects
HumiraCimzia
  • Taking other immunosuppressant medications such as Kineret or Orencia
  • Age 65 or older
  • Active, chronic, or recurrent infection
  • Comorbidities
  • Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Humira (adalimumab)
Detailed Humira (adalimumab) risks & warnings »
  • Medications that lower immune system function
  • Younger age
  • History of heart failure
Detailed Cimzia (certolizumab) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Upsides and benefits
HumiraCimzia
  • Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
  • You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
  • Humira (adalimumab) treats many different autoimmune conditions.
  • Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
  • In studies, people with RA (rheumatoid arthritis) taking methotrexate had improved symptoms when Cimzia (Certolizumab) was added to methotrexate.
  • Cimzia (Certolizumab) is as effective as other similar medicines for Crohn's disease. It can be an option for people taking other RA medications that have too many side effects of don't work anymore.
  • Cimzia (Certolizumab) lasts longer in the body than other RA medications, letting it work longer.
  • Available in a prefilled syringe. This can make it easier to give yourself the injection.
Downsides and risks
HumiraCimzia
  • Not first-choice treatment for rheumatoid arthritis.
  • Humira (adalimumab) is an injection and not an oral medication.
  • Humira (adalimumab) is expensive because there's no generic available yet.
  • Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
  • You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
  • Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
  • Can lower your immune system's ability to fight infections. You can get serious infections such as TB (tuberculosis) and infections caused by viruses, fungi, or bacteria.
  • Can have a higher risk for causing bladder infections, rash, and upper respiratory infections (cold or flu) compared to other similar medicines.
  • Cimzia (Certolizumab) can increase the risk of lymphoma, leukemia, and other cancers.
  • Requires routine tests to check for infections.
  • Not a good choice if you have a history of heart failure, nervous system problems, or hepatitis B.
  • There's no generic available and it can be very expensive.
Tips from our pharmacists for people taking the medication
HumiraCimzia
  • Humira (adalimumab) is a medication that's injected under the skin. Your doctor can give you your first dose, then you can inject yourself at home once you feel comfortable doing so on your own.
  • Humira (adalimumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
  • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
  • Each time you use Humira (adalimumab), it's important to rotate the sites you chose to inject it in. Don't inject Humira (adalimumab) into skin that's red, bruised, or irritated.
  • As with all injection medicines, store securely away from children and throw away used syringes in an FDA-approved sharps disposal container, and not in the trash.
  • Cimzia (Certolizumab) is a medicine that's injected just under the skin (subcutaneous). It can be given in your doctor's office or you can do it yourself at home.
  • It can take multiple doses before you start to see any effects, so don't change your dose without talking to your doctor.
  • Tell your doctor if you have night sweats, persistent fever, fatigue, weight loss, or swollen lymph nodes.
  • You'll need to have a TB (tuberculosis) test before you start Cimzia (Certolizumab) and periodically during treatment.
  • Don't get any live vaccines while you're taking Cimzia (Certolizumab) since they may not work as well. Wait at least 3 months after you've stopped taking Cimzia (Certolizumab) before getting a live vaccine.
Learn more
More about HumiraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Humira (adalimumab)?
Worth itNot sureNot worth it
More about CimziaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Cimzia (certolizumab)?
Worth itNot sureNot worth it