Compare Humira vs. Enbrel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Humira
(adalimumab)

Enbrel
(etanercept)

Calms down the immune system. Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects.Calms down your immune system. Enbrel (Etanercept) is very effective at calming down your immune system, but it's expensive, you have to take into account the hassle of injections and traveling with the medication.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for Humira
Best available price for 1 (2 pens of 40mg/0.8ml) carton of adalimumab
Coupons for Enbrel
Best available price for 1 (4 sureclicks of 50mg) carton of etanercept
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.94Humira
Reviews for Humira (adalimumab)
60%
of people (All ages) say Humira (adalimumab) is worth it
51%
say it works well
26%
say it's a big hassle
182 reviews
Have you used Humira (adalimumab)?
Worth itNot sureNot worth it
Reviews for Enbrel (etanercept)
62%
+2% better vs. Humira (adalimumab)
53%
+2% better vs. Humira (adalimumab)
17%
+9% better vs. Humira (adalimumab)
Have you used Enbrel (etanercept)?
Worth itNot sureNot worth it
Side effects
HumiraEnbrel
  • Upper airway infection 4%
  • Rash 6%
  • Headache 4%
  • Sinus infection 2%
  • Nausea 1%
  • Injection site reactions 7%
  • Urinary tract infection 3%
  • Flu syndrome 1%
  • Stomach pain 3%
  • High cholesterol 2%
More Humira side effects »
  • Positive anti-double-stranded dna antibodies 11%
  • Antibodies to etanercept 6%
  • Crithidia luciliae 3%
  • Anticardiolipin 3%
  • Mild or moderate skin reactions 15%
  • Any infection 11%
  • Upper respiratory infections 8%
  • Injection site reactions 26%
  • Non-upper respiratory infections 6%
  • Positive ana 6%
More Enbrel side effects »
How it works
HumiraEnbrel
Humira (adalimumab) is a TNF blocker which stops inflammation.Enbrel (Etanercept) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.
Type of medication
HumiraEnbrel
Prescription only
Prescription only
Available as
HumiraEnbrel
  • Injection
  • Injection
Used for
HumiraEnbrel
Risk factors for serious side effects
HumiraEnbrel
  • Taking other immunosuppressant medications such as Kineret or Orencia
  • Age 65 or older
  • Active, chronic, or recurrent infection
  • Comorbidities
  • Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Humira (adalimumab)
Detailed Humira (adalimumab) risks & warnings »
  • History of heart failure
  • Taking other immunosuppressant drugs
  • Age 60 or older
  • History of malignancy
Detailed Enbrel (etanercept) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Upsides and benefits
HumiraEnbrel
  • Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
  • You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
  • Humira (adalimumab) treats many different autoimmune conditions.
  • Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
  • Treats certain types of arthritis conditions caused by an overactive immune system.
  • Enbrel is the first biologic approved for moderate to severe rheumatoid arthritis.
  • It has an established safety profile for treatment of rheumatoid arthritis (RA).
  • Available as a single-use syringe and SureClick auto-injector pen which may be more convenient and easier for some people to use.
  • People taking Enbrel for rheumatoid arthritis showed significant improvement and were able to reduce the dose or stop immunosuppressant medicines.
Downsides and risks
HumiraEnbrel
  • Not first-choice treatment for rheumatoid arthritis.
  • Humira (adalimumab) is an injection and not an oral medication.
  • Humira (adalimumab) is expensive because there's no generic available yet.
  • Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
  • You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
  • Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
  • It's an injection.
  • It's expensive because there's no generic available yet.
  • Enbrel lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
  • You're first dose of Enbrel will need to be given at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
  • You'll need to properly dispose of the needle, syringes, or Pen in a special (FDA-approved) sharps container.
  • Because it needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
Tips from our pharmacists for people taking the medication
HumiraEnbrel
  • Humira (adalimumab) is a medication that's injected under the skin. Your doctor can give you your first dose, then you can inject yourself at home once you feel comfortable doing so on your own.
  • Humira (adalimumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
  • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
  • Each time you use Humira (adalimumab), it's important to rotate the sites you chose to inject it in. Don't inject Humira (adalimumab) into skin that's red, bruised, or irritated.
  • As with all injection medicines, store securely away from children and throw away used syringes in an FDA-approved sharps disposal container, and not in the trash.
  • Enbrel (Etanercept) is available as a single-use prefilled syringe, single-use prefilled SureClick Autoinjector, and multiple-use vial. You and your doctor can discuss which is best for you.
  • The autoinjector can be stored at room temperature for up to 14 days and can't be refrigerated again.
  • Enbrel (Etanercept) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once so you learn how to do it correctly.
  • Enbrel (Etanercept) lowers the your immune system's ability to fight infections, so it's important to let your doctor know if you come down with a fever, cough, or notice flu-like symptoms.
  • You'll need to have a TB test before you start using Enbrel (Etanercept).
  • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
  • Don't inject Enbrel (Etanercept) into skin that's red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
  • As with all injection medicines, store away from children and throw used syringes away in a protective container, and not in the trash.
Learn more
More about HumiraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Humira (adalimumab)?
Worth itNot sureNot worth it
More about EnbrelSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Enbrel (etanercept)?
Worth itNot sureNot worth it