Compare Humira vs. Imbruvica

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Calms down your immune system. Humira (Adalimumab) is very effective at calming down your immune system, but it's expensive, you have to take into account the hassle of injections and traveling with the medication.Coming soon.
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Reviews & ratings
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Reviews for Humira (Adalimumab)
of people (All ages) say Humira (Adalimumab) is worth it
say it works well
say it's a big hassle
182 reviews
Have you used Humira (Adalimumab)?
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Have you used Imbruvica (Ibrutinib)?
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Side effects
  • Injection site reactions 6%
  • Serious infections 2%
  • Alt increased (>3x) 2%
  • Upper respiratory infection 4%
  • Positive titers 5%
  • Rash 6%
  • Headache 4%
  • Sinus inflammation 2%
  • Accidental injury 2%
  • Nausea 1%
More Humira side effects »

We haven’t found good data for Imbruvica side effects.

FDA side effect reports for Imbruvica »
How it works
Humira (Adalimumab) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.Coming soon.
Type of medication
Prescription only
Available as
  • Injection
  • Pill
Used for
  • Chronic Lymphoid Leukemia
Risk factors for serious side effects
    • History of heart failure
    • Taking other immunosuppressant drugs
    • Age 60 or older
    • Taking other immunosuppressant drugs
    • History of malignancy
    • History of neurologic condition
      Detailed Humira (Adalimumab) risks & warnings »
      Coming soon.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Upsides and benefits
      • Treats certain types of arthritis and gastrointestinal conditions caused by an overactive immune system.
      • Most people feel it's worth the hassle.
      • Once you've learned the correct way to use Humira, you can inject the medicine yourself without going to your doctor's office.
      • It's available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
      • It's an alternative for people with Crohn's disease who stopped getting better on other TNF-blockers or had side effects that made them switch.
      Coming soon
      Downsides and risks
      • It's an injection.
      • It's expensive because there's no generic available yet.
      • Humira lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
      • You're first dose of Humira will need to be given at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
      • You'll need to properly dispose of the needle, syringes, or Pen in a special (FDA-approved) sharps container.
      • Because it needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
      Coming soon
      Tips from our pharmacists for people taking the medication
      • Humira (Adalimumab) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once so you learn how to do it correctly.
      • Humira (Adalimumab) lowers the your immune system's ability to fight infections, so it's important to let your doctor know if you come down with a fever, cough, or notice flu-like symptoms.
      • You'll need to have a TB test before you start using Humira (Adalimumab).
      • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
      • Don't inject Humira (Adalimumab) into skin that's red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
      • As with all injection medicines, store away from children and throw used syringes away in a protective container, and not in the trash.
      Coming soon
      Learn more
      More about HumiraSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Humira (Adalimumab)?
      Worth itNot sureNot worth it
      More about ImbruvicaSide effectsReviews & ratingsFDA package insert
      Have you used Imbruvica (Ibrutinib)?
      Worth itNot sureNot worth it