Compare Humira vs. Methotrexate

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Humira
(adalimumab)

Otrexup
(methotrexate)

Calms down the immune system. Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects.Treats cancer and changes how your immune system works. Otrexup (Methotrexate) is a first line treatment for many autoimmune diseases and types of cancer. If you're taking it for a long time, you'll have to get routine blood tests.
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Coupons for Humira
Best available price for 1 (2 pens of 40mg/0.8ml) carton of adalimumab
Coupons for Methotrexate
Best available price for 24 (2.5mg) tablets of methotrexate
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.94Humira
Reviews for Humira (adalimumab)
60%
of people (All ages) say Humira (adalimumab) is worth it
51%
say it works well
26%
say it's a big hassle
182 reviews
Have you used Humira (adalimumab)?
Worth itNot sureNot worth it
Reviews for Otrexup (methotrexate)
Not enough review data. Review it!
+15% better vs. Humira (adalimumab)
Not enough review data. Review it!
-1% worse vs. Humira (adalimumab)
Not enough review data. Review it!
+26% better vs. Humira (adalimumab)
Have you used Otrexup (methotrexate)?
Worth itNot sureNot worth it
Side effects
HumiraMethotrexate
  • Upper airway infection 4%
  • Rash 6%
  • Headache 4%
  • Sinus infection 2%
  • Nausea 1%
  • Injection site reactions 7%
  • Urinary tract infection 3%
  • Flu syndrome 1%
  • Stomach pain 3%
  • High cholesterol 2%
More Humira side effects »
  • Elevated liver function tests 15%
  • Nausea/vomiting 10%
  • Mouth and lip swelling 10%
  • Thrombocytopenia 10%
  • Rash/pruritus/dermatitis 3%
  • Diarrhea 3%
  • Hair loss or baldness 3%
  • Low white blood cells 3%
  • Low blood cell count 3%
  • Dizziness 3%
More Methotrexate side effects »
How it works
HumiraMethotrexate
Humira (adalimumab) is a TNF blocker which stops inflammation.Otrexup (Methotrexate) is an anti-cancer and immunosuppressive medication that treats forms of cancer, arthritis, and psoriasis. For cancer, it helps your body destroy cancer cells by blocking building blocks that cancer cells need to grow. For rheumatoid arthritis and psoriasis, it lowers the body's normal immune response and prevents the body from attacking itself.
Type of medication
HumiraMethotrexate
Prescription only
Prescription only
Available as
HumiraMethotrexate
  • Injection
  • Pill
  • Injection
Used for
HumiraMethotrexate
Risk factors for serious side effects
HumiraMethotrexate
  • Taking other immunosuppressant medications such as Kineret or Orencia
  • Age 65 or older
  • Active, chronic, or recurrent infection
  • Comorbidities
  • Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Humira (adalimumab)
Detailed Humira (adalimumab) risks & warnings »
  • Women of childbearing age
  • Men of childbearing potential
  • Reduced kidney function
  • fluid in the abdomen (ascites)
  • fluid in the lungs (pleural effusion)
Detailed Otrexup (methotrexate) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Alcohol
HumiraMethotrexate
No alcohol related info.
  • You have to avoid alcohol and being in the sun too long.
  • Don't use alcohol, NSAIDs (anti-inflammatory medications), or stay in the sun too long.
Upsides and benefits
HumiraMethotrexate
  • Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
  • You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
  • Humira (adalimumab) treats many different autoimmune conditions.
  • Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
  • Recommended as first line treatment for rheumatoid arthritis.
  • Available as a generic medication. Comes as a tablet, an injection that you give yourself weekly, and as an infusion that you get in your doctor's office or at an infusion center.
  • If you accidentally take too much, there's an antidote to help your body recover.
Downsides and risks
HumiraMethotrexate
  • Not first-choice treatment for rheumatoid arthritis.
  • Humira (adalimumab) is an injection and not an oral medication.
  • Humira (adalimumab) is expensive because there's no generic available yet.
  • Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
  • You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
  • Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
  • You have to be on birth control for at least 2 to 3 months after you finish Otrexup (Methotrexate) since it can cause birth defects.
  • You have to avoid alcohol and being in the sun too long.
  • You'll have to get blood tests done if you're taking this long-term because it can cause harmful side effects.
Tips from our pharmacists for people taking the medication
HumiraMethotrexate
  • Humira (adalimumab) is a medication that's injected under the skin. Your doctor can give you your first dose, then you can inject yourself at home once you feel comfortable doing so on your own.
  • Humira (adalimumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
  • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
  • Each time you use Humira (adalimumab), it's important to rotate the sites you chose to inject it in. Don't inject Humira (adalimumab) into skin that's red, bruised, or irritated.
  • As with all injection medicines, store securely away from children and throw away used syringes in an FDA-approved sharps disposal container, and not in the trash.
  • Don't use alcohol, NSAIDs (anti-inflammatory medications), or stay in the sun too long.
  • Use birth control and avoid pregnancy for at least 2 months (for women) and 3 months (for men) after you finish Otrexup (Methotrexate).
  • Drink plenty of liquids to stay hydrated while taking this.
  • Take the medication exactly as your doctor or pharmacist tells you. Call your doctor or pharmacist if you're confused.
Learn more
More about HumiraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Humira (adalimumab)?
Worth itNot sureNot worth it
More about MethotrexateSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Otrexup (methotrexate)?
Worth itNot sureNot worth it