Compare Humira vs. Orencia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Humira
(adalimumab)

Orencia
(abatacept)

Calms down the immune system. Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects.Orencia (Abatacept) decreases inflammation in rheumatoid arthritis. Orencia (Abatacept) slows the progress of rheumatoid arthritis, but can also have serious side effects.
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Coupons for Humira
Best available price for 1 (2 pens of 40mg/0.8ml) carton of adalimumab
Coupons for Orencia
Best available price for 1 (4 syringes of 125mg/ml) carton of abatacept
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.94Humira
Reviews for Humira (adalimumab)
60%
of people (All ages) say Humira (adalimumab) is worth it
51%
say it works well
26%
say it's a big hassle
182 reviews
Have you used Humira (adalimumab)?
Worth itNot sureNot worth it
Reviews for Orencia (abatacept)
Not enough review data. Review it!
+20% better vs. Humira (adalimumab)
Not enough review data. Review it!
+29% better vs. Humira (adalimumab)
Not enough review data. Review it!
+16% better vs. Humira (adalimumab)
Have you used Orencia (abatacept)?
Worth itNot sureNot worth it
Side effects
HumiraOrencia
  • Upper airway infection 4%
  • Rash 6%
  • Headache 4%
  • Sinus infection 2%
  • Nausea 1%
  • Injection site reactions 7%
  • Urinary tract infection 3%
  • Flu syndrome 1%
  • Stomach pain 3%
  • High cholesterol 2%
More Humira side effects »
  • Headache 5%
  • Common cold 3%
  • Dizziness 2%
  • Cough 1%
  • Back pain 1%
  • High blood pressure 3%
  • Indigestion 2%
  • Urinary tract infection 1%
  • Rash 1%
  • Pain in extremity 1%
More Orencia side effects »
How it works
HumiraOrencia
Humira (adalimumab) is a TNF blocker which stops inflammation.Orencia (Abatacept) is called a DMARD, a disease-modifying antirheumatic drug. It prevents your body from activating cells that cause inflammation.
Type of medication
HumiraOrencia
Prescription only
Prescription only
Available as
HumiraOrencia
  • Injection
  • Injection
Used for
HumiraOrencia
Risk factors for serious side effects
HumiraOrencia
  • Taking other immunosuppressant medications such as Kineret or Orencia
  • Age 65 or older
  • Active, chronic, or recurrent infection
  • Comorbidities
  • Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Humira (adalimumab)
Detailed Humira (adalimumab) risks & warnings »
  • Taking immunosuppressive medications
  • History of repeat infections
  • Adults with rheumatoid arthritis taking TNF inhibitors
Detailed Orencia (abatacept) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Upsides and benefits
HumiraOrencia
  • Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
  • You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
  • Humira (adalimumab) treats many different autoimmune conditions.
  • Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
  • Helps minimize joint damage, lowers symptoms, and prevents future problems.
  • In a 2-year study that used IV Orencia (Abatacept) with methotrexate, more than half of the people had remission and the majority felt significantly better.
  • People taking [name-common] had no new joint damage after two years.
  • Taking Orencia (Abatacept) allows RA patients to use less prednisone, a steroid that has many side effects.
  • Orencia (Abatacept) can be used without other medications for RA.
Downsides and risks
HumiraOrencia
  • Not first-choice treatment for rheumatoid arthritis.
  • Humira (adalimumab) is an injection and not an oral medication.
  • Humira (adalimumab) is expensive because there's no generic available yet.
  • Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
  • You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
  • Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
  • You'll have to get your blood tested regularly while taking Orencia (Abatacept).
  • You'll probably have to take other medications to help treat your RA symptoms.
  • Orencia (Abatacept) is pretty expensive.
  • The IV infusion form of Orencia (Abatacept) can cause a reaction, which ranges from a slight itching or warm feeling to more serious complications like low blood pressure and chest pain.
  • Because RA is chronic disease, you'll likely take Orencia (Abatacept) for many years.
Tips from our pharmacists for people taking the medication
HumiraOrencia
  • Humira (adalimumab) is a medication that's injected under the skin. Your doctor can give you your first dose, then you can inject yourself at home once you feel comfortable doing so on your own.
  • Humira (adalimumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
  • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
  • Each time you use Humira (adalimumab), it's important to rotate the sites you chose to inject it in. Don't inject Humira (adalimumab) into skin that's red, bruised, or irritated.
  • As with all injection medicines, store securely away from children and throw away used syringes in an FDA-approved sharps disposal container, and not in the trash.
  • Keep the Orencia (Abatacept) self-injection refrigerated, but let it rest at room temperature for 30 to 60 minutes before using it.
  • Each time you use Orencia (Abatacept), be sure to rotate the sites you chose to inject it in. Don't inject it where your skin is tender, bruised, red, or scaly.
  • If you decide to go with the IV version of Orencia (Abatacept), you will only need to get infusions once a month. The self-injections however need to be taken once a week.
  • If you get the IV infusion, stay hydrated, try to relax, and ask your nurse to apply dry heat (instant warm packs) to your arm to help find your good veins.
Learn more
More about HumiraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Humira (adalimumab)?
Worth itNot sureNot worth it
More about OrenciaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Orencia (abatacept)?
Worth itNot sureNot worth it