Humira (adalimumab) is a TNF blocker which stops inflammation.
Remicade (Infliximab) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.
› Although rare, Remicade (Infliximab) can cause serious liver injury. You'll need to have your liver enzymes tested regularly. If liver enzymes are significantly elevated and you have appetite/weight loss, stomach discomfort, vomiting, and notice dark urine, yellowing of skin/eyes, change in stool color, and skin rash you should stop treatment with Remicade (Infliximab) until you can be completely assessed,
Upsides and benefits
› Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
› You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
› Humira (adalimumab) treats many different autoimmune conditions.
› Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
› Treats certain types of arthritis and gastrointestinal conditions caused by an overactive immune system.
› Remicade has almost two decades of clinical trial data and real-life experience with millions of people who have used it.
› Initial dosing to introduce Remicade to your body might be a hassle, but then you only need to take it every 6-8 weeks depending on your condition.
Downsides and risks
› Not first-choice treatment for rheumatoid arthritis.
› Humira (adalimumab) is an injection and not an oral medication.
› Humira (adalimumab) is expensive because there's no generic available yet.
› Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
› You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
› Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
› You have to get every dose through an IV infusion at your doctor's office.
› It's expensive because there's no generic available yet.
› Remicade has a higher risk of serious infusion-related side effects during or after it's given since it's injected right into your veins. Your doctor can prescribe medication before your dose that may lower this risk.
› Remicade lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
› Not the best choice if you have heart failure.
› Talk to your baby's doctor if you're pregnant or breast-feeding. When women in a study took Remicade (Infliximab), the medicine was found in their breast milk 2 to 3 days after each dose, and in the baby's blood 6 months after they were born.
Tips from our pharmacists for people taking the medication
› Humira (adalimumab) is a medication that's injected under the skin. Your doctor can give you your first dose, then you can inject yourself at home once you feel comfortable doing so on your own.
› Humira (adalimumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
› Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
› Each time you use Humira (adalimumab), it's important to rotate the sites you chose to inject it in. Don't inject Humira (adalimumab) into skin that's red, bruised, or irritated.
› As with all injection medicines, store securely away from children and throw away used syringes in an FDA-approved sharps disposal container, and not in the trash.
› Remicade (Infliximab) is a medication that's given as an infusion at your doctor's office or clinic.
› It's very important to read the patient Medication Guide when you first start using Remicade (Infliximab).
› It's possible to get an allergic reaction to Remicade (Infliximab) either immediately during the treatment or a several days after stopping it. Your doctor can give you medicines that'll lower this risk.
› You'll need to have a TB test before you start taking Remicade (Infliximab) and periodically during treatment.
› Remicade (Infliximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, cough, or flu-like symptoms. Children seem to get more infections than adults, so keep a close eye on them.
› If you have a young child, let their doctor know if you were on Remicade (Infliximab) while pregnant or nursing. It can increase their risk of infections for several months after your last dose and can delay their vaccine schedule.