Compare Humira vs. Rituxan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Humira
(adalimumab)

Rituxan
(rituximab)

Calms down the immune system. Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects.Calms down your immune system. Rituxan (Rituximab) is effective for treating multiple types of cancer and arthritis. That said, you'll need to watch for possibly serious side effects, especially infusion reactions.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for Humira
Best available price for 1 (2 pens of 40mg/0.8ml) carton of humira
Coupons for Rituxan
Best available price for 1 (10ml of 10mg/ml) vial of rituximab
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.94Humira
Reviews for Humira
60%
of people (All ages) say Humira is worth it
51%
say it works well
26%
say it's a big hassle
182 reviews
Have you used Humira (adalimumab)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Rituxan (rituximab)?
Worth itNot sureNot worth it
Side effects
HumiraRituxan
  • Upper airway infection 4%
  • Rash 6%
  • Headache 4%
  • Sinus infection 2%
  • Nausea 1%
  • Injection site reactions 7%
  • Urinary tract infection 3%
  • Flu syndrome 1%
  • Stomach pain 3%
  • High cholesterol 2%
More Humira side effects »
  • Fever 60%
  • Lung disorder 31%
  • Cardiac disorder 28%
  • Chills 13%
  • Any infection 62%
  • Infusion reaction 12%
  • Any serious infection 11%
  • Cardiac side effect 1%
  • Tested positive for haca 23%
More Rituxan side effects »
How it works
HumiraRituxan
Humira (adalimumab) is a TNF blocker which stops inflammation.Rituxan (Rituximab) is a monoclonal antibody. It targets a specific protein on white blood cells that makes it easier for your immune system to find and destroy cancerous cells. It also relieves symptoms and slows the progression of Rheumatoid Arthritis.
Type of medication
HumiraRituxan
Prescription onlyPrescription only
Available as
HumiraRituxan
  • Injection
  • Infusion (iv)
Used for
HumiraRituxan
Risk factors for serious side effects
HumiraRituxan
  • Taking other immunosuppressant medications such as Kineret or Orencia
  • Age 65 or older
  • Active, chronic, or recurrent infection
  • Comorbidities
  • Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Humira (adalimumab)
Detailed Humira (adalimumab) risks & warnings »
  • Taking other immunosuppressant drugs
  • Age 60 or older
  • Weak immune system
  • Taking Rituxan (Rituximab) with immunosuppressant drugs (if using for RA)
  • Taking Rituxan (Rituximab) with chemotherapy (if using for NHL or CLL
Detailed Rituxan (rituximab) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
HumiraRituxan
No kidneys and liver related info.
  • Discuss with your doctor the serious heart, kidney, liver, or stomach problems that can happen while on Rituxan (Rituximab).
Upsides and benefits
HumiraRituxan
  • Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
  • You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
  • Humira (adalimumab) treats many different autoimmune conditions.
  • Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
  • Treats leukemia, lymphoma, and blood vessel inflammation.
  • Also treats moderate to severe rheumatoid arthritis that hasn't responded to anti-TNF treatment (but you'll need to take methotrexate too).
  • The chance of having a reaction to the infusion is highest during your first dose, but the risk decreases each time you get Rituxan (Rituximab). It usually happens within 30 minutes to 2 hours after starting the infusion.
  • Rituxan (Rituximab) is a targeted therapy that works differently than chemotherapy. Both work well when they're taken together, especially when treating CLL and NHL.
Downsides and risks
HumiraRituxan
  • Not first-choice treatment for rheumatoid arthritis.
  • Humira (adalimumab) is an injection and not an oral medication.
  • Humira (adalimumab) is expensive because there's no generic available yet.
  • Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
  • You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
  • Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
  • Only your doctor or other trained medical staff can administer Rituxan (Rituximab), so you'll need to go into an office or clinic for every dose.
  • Not the best choice if you have heart problems.
  • Rituxan (Rituximab) can stay in your body for up to 6 months after you complete treatment. Men and women who are able to have children need to use birth control for up to one year after finishing Rituxan (Rituximab).
  • Discuss with your doctor the serious heart, kidney, liver, or stomach problems that can happen while on Rituxan (Rituximab).
Tips from our pharmacists for people taking the medication
HumiraRituxan
  • Humira (adalimumab) is a medication that's injected under the skin. Your doctor can give you your first dose, then you can inject yourself at home once you feel comfortable doing so on your own.
  • Humira (adalimumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
  • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
  • Each time you use Humira (adalimumab), it's important to rotate the sites you chose to inject it in. Don't inject Humira (adalimumab) into skin that's red, bruised, or irritated.
  • As with all injection medicines, store securely away from children and throw away used syringes in an FDA-approved sharps disposal container, and not in the trash.
  • Rituxan (Rituximab) is given as an IV infusion by trained medical staff in a clinic or hospital.
  • You'll need to be monitored in the clinic in case you have a serious or life-threatening reaction during the infusion, but you can take other medications that'll lower your risk of this happening.
  • It's very important that you read the Medication Guide before you start taking Rituxan (Rituximab).
  • Rituxan (Rituximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, a cough that doesn't go away, or flu-like symptoms.
  • Use effective birth control while you're taking Rituxan (Rituximab) and for 12 months after you finish treatment.
  • Don't get live vaccines while you're taking Rituxan (Rituximab).
Learn more
More about HumiraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Humira (adalimumab)?
Worth itNot sureNot worth it
More about RituxanSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Rituxan (rituximab)?
Worth itNot sureNot worth it