Compare Humira vs. Rituxan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Humira (adalimumab)

Prescription only

Rituxan (Rituximab)

Prescription only
Calms down the immune system.

Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects.

3.6/ 5 average rating with 182 reviewsforHumira
Calms down your immune system.

Rituxan (Rituximab) is effective for treating multiple types of cancer and arthritis. That said, you'll need to watch for possibly serious side effects, especially infusion reactions.

Upsides
  • Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
  • You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
  • Humira (adalimumab) treats many different autoimmune conditions.
  • Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
  • Treats leukemia, lymphoma, and blood vessel inflammation.
  • Also treats moderate to severe rheumatoid arthritis that hasn't responded to anti-TNF treatment (but you'll need to take methotrexate too).
  • The chance of having a reaction to the infusion is highest during your first dose, but the risk decreases each time you get Rituxan (Rituximab). It usually happens within 30 minutes to 2 hours after starting the infusion.
  • Rituxan (Rituximab) is a targeted therapy that works differently than chemotherapy. Both work well when they're taken together, especially when treating CLL and NHL.
Downsides
  • Not first-choice treatment for rheumatoid arthritis.
  • Humira (adalimumab) is an injection and not an oral medication.
  • Humira (adalimumab) is expensive because there's no generic available yet.
  • Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
  • You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
  • Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
  • Only your doctor or other trained medical staff can administer Rituxan (Rituximab), so you'll need to go into an office or clinic for every dose.
  • Not the best choice if you have heart problems.
  • Rituxan (Rituximab) can stay in your body for up to 6 months after you complete treatment. Men and women who are able to have children need to use birth control for up to one year after finishing Rituxan (Rituximab).
  • Discuss with your doctor the serious heart, kidney, liver, or stomach problems that can happen while on Rituxan (Rituximab).
Used for
Dosage forms
  • Injection
  • Infusion (IV)
Price
Lowest price
$4537.05
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Reviews
182 reviews so far
60%
saidit'sworth it
51%
saiditworked well
26%
saidit'sa big hassle

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Side effects
14possible side effects
  • Upper airway infection
    17%
  • Headache
    12%
  • Rash
    12%
  • Sinus infection
    11%
  • Nausea
    9%
  • Injection site reactions
    8%
  • Urinary tract infection
    8%
  • Flu syndrome
    7%
  • Stomach pain
    7%
  • High cholesterol
    7%
  • Back pain
    6%
  • Blood in urine
    5%
  • Abnormal liver tests
    5%
  • High blood pressure
    5%
See more detailed side effects
4possible side effects
  • Any infection
    62%
  • Infusion reaction
    12%
  • Any serious infection
    11%
  • Cardiac side effect
    2%
See more detailed side effects
Risks and risk factors
  • Serious infections
    • Taking other immunosuppressant medications such as Kineret or Orencia
    • Age 65 or older
    • Active, chronic, or recurrent infection
    • Comorbidities
  • Cancers
    • Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Humira (adalimumab)
    • History of malignancy
    • Adolescent age
    • COPD with significant smoking history
  • Serious allergic reactions
  • Heart problems
    • History of heart failure
  • Nervous system effects
    • Preexisting or recently acquired neurologic condition
  • Lower blood cell counts
See more detailed risks and warnings
  • Serious allergic reactions
  • Serious infections
    • Taking other immunosuppressant drugs
    • Age 60 or older
    • Weak immune system
  • Nervous system effects
    • Taking Rituxan (Rituximab) with immunosuppressant drugs (if using for RA)
    • Taking Rituxan (Rituximab) with chemotherapy (if using for NHL or CLL
    • Stem cell transplant
  • Skin and mouth reactions
  • Kidney injury
    • Taking Rituxan (Rituximab) for Non-Hodgkin's Lymphoma (NHL)
    • Rapidly growing tumors
  • Heart problems
    • History of heart problems
    • Drug interactions
  • Gastrointestinal problems
    • Start of therapy with Rituxan (Rituximab)
  • Blood problems
See more detailed risks and warnings