Compare Humira vs. Simponi

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Humira
(adalimumab)

Simponi
(golimumab)

Calms down the immune system. Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects.Calms down the immune system. Simponi (golimumab) effectively calms down your immune system, but it is given as a shot and puts you at risk of serious infections like tuberculosis or hepatitis B.
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Best available price for 2 (2 pens of 40mg/0.8ml) cartons of humira
Reviews & ratings
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Filter group. All currently selected
4.94Humira
Reviews for Humira
60%
of people (All ages) say Humira is worth it
51%
say it works well
26%
say it's a big hassle
182 reviews
Have you used Humira (adalimumab)?
Worth itNot sureNot worth it

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Have you used Simponi (golimumab)?
Worth itNot sureNot worth it
Side effects
HumiraSimponi
  • Upper airway infection 4%
  • Rash 6%
  • Headache 4%
  • Sinus infection 2%
  • Nausea 1%
  • Injection site reactions 7%
  • Urinary tract infection 3%
  • Flu syndrome 1%
  • Stomach pain 3%
  • High cholesterol 2%
More Humira side effects »
  • Common cold 3%
  • Injection site reaction 4%
  • Viral infections (such as influenza and herpes) 2%
  • Increased liver function test (alt) 1%
  • Increased liver function test (ast) 1%
  • High blood pressure 1%
  • Bronchitis 1%
  • Superficial fungal infections 1%
  • Tingling sensation 1%
  • Dizziness 1%
More Simponi side effects »
How it works
HumiraSimponi
Humira (adalimumab) is a TNF blocker which stops inflammation.Simponi (golimumab) blocks a protein called TNF (tumor necrosis factor) that revs up the immune system. Blocking TNF lowers inflammation, relieves symptoms and prevents disease progression. Simponi (golimumab) is also known as a biologic DMARD (disease-modifying anti-rheumatic drug) - or just a "biologic" - when used to treat rheumatoid arthritis.
Type of medication
HumiraSimponi
Prescription onlyPrescription only
Available as
HumiraSimponi
  • Injection
  • Injection
Used for
HumiraSimponi
Risk factors for serious side effects
HumiraSimponi
  • Taking other immunosuppressant medications such as Kineret or Orencia
  • Age 65 or older
  • Active, chronic, or recurrent infection
  • Comorbidities
  • Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Humira (adalimumab)
Detailed Humira (adalimumab) risks & warnings »
  • Taking other immunosuppressant drugs
  • Age 65 or older
  • Active, chronic, or recurrent infection
  • History of malignancy
Detailed Simponi (golimumab) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Upsides and benefits
HumiraSimponi
  • Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
  • You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
  • Humira (adalimumab) treats many different autoimmune conditions.
  • Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
  • Simponi (golimumab) is only injected once a month.
  • Simponi (golimumab) comes in a prefilled syringe or autoinjector. You won't need to measure out the medication.
  • While taking Simponi (golimumab), you may continue to use other drugs prescribed by your doctor that help treat your condition, such as NSAIDS (like ibuprofen) and steroids.
Downsides and risks
HumiraSimponi
  • Not first-choice treatment for rheumatoid arthritis.
  • Humira (adalimumab) is an injection and not an oral medication.
  • Humira (adalimumab) is expensive because there's no generic available yet.
  • Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
  • You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
  • Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
  • Like other immunosuppressive drugs, Simponi (golimumab) can awaken (reactivate) infections.
  • Simponi (golimumab) can increase the risk of lymphoma, leukemia, and other cancers.
  • Not the best choice if you have a history of heart failure or nervous system problems like multiple sclerosis.
  • You'll need to have regular blood tests before and during treatment to make sure you don't have any problems taking Simponi (golimumab).
Tips from our pharmacists for people taking the medication
HumiraSimponi
  • Humira (adalimumab) is a medication that's injected under the skin. Your doctor can give you your first dose, then you can inject yourself at home once you feel comfortable doing so on your own.
  • Humira (adalimumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
  • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
  • Each time you use Humira (adalimumab), it's important to rotate the sites you chose to inject it in. Don't inject Humira (adalimumab) into skin that's red, bruised, or irritated.
  • As with all injection medicines, store securely away from children and throw away used syringes in an FDA-approved sharps disposal container, and not in the trash.
  • Simponi (golimumab) is an immunosuppressant medication that's injected under the skin (subcutaneous) once a month.
  • Simponi (golimumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
  • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
  • Each time you use Simponi (golimumab), it's important to rotate the sites you chose to inject it in (either your abdomen, thigh, or upper arm). Don't inject Simponi (golimumab) into skin that's red, bruised, or irritated.
  • Keep it refrigerated, and let it sit at room temperature for about 30 minutes before injecting yourself. Do not shake the Simponi (golimumab) autoinjector at any time.
  • People taking Simponi (golimumab) should not get live vaccines. Talk to your doctor before receiving any vaccines.
Learn more
More about HumiraSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Humira (adalimumab)?
Worth itNot sureNot worth it
More about SimponiSide effectsAlternativesFDA package insert
Have you used Simponi (golimumab)?
Worth itNot sureNot worth it