Compare Humira vs. Stelara

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Humira (adalimumab)

Prescription only

Stelara (Ustekinumab)

Prescription only
Calms down the immune system.

Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects.

4.9/ 7 average rating with 182 reviewsforHumira
Treats moderate to severe psoriasis.

Stelara (Ustekinumab) works for two psoriatic conditions. It may be somewhat of a hassle because of the injection, but after the first two doses, you only need to take it every 12 weeks.

4.2/ 7 average rating with 50 reviewsforStelara
Upsides
  • Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
  • You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
  • Humira (adalimumab) treats many different autoimmune conditions.
  • Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
  • Stelara (Ustekinumab) works throughout your whole body (systemic therapy) and may be better than just applying medicine to your skin (local therapy) for moderate or severe plaque psoriasis that covers large areas or many areas of your body.
  • It's used alone or together with another medicine called methotrexate for better results to treat active psoriatic arthritis.
  • Initial dosing might be a hassle, but then you only have to take it every 12 weeks.
  • People treated with Stelara (Ustekinumab) for psoriatic arthritis felt better and had more physical improvement compared to not using the medicine (placebo).
Downsides
  • Not first-choice treatment for rheumatoid arthritis.
  • Humira (adalimumab) is an injection and not an oral medication.
  • Humira (adalimumab) is expensive because there's no generic available yet.
  • Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
  • You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
  • Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
  • It's an injection.
  • Stelara (Ustekinumab) lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
  • You have to get your first dose of Stelara (Ustekinumab) at your doctor's office. If you decide not to self-inject and don't have someone to do it for you, you'll need to continue to see your doctor for each dose.
  • You'll need to properly dispose of the needle and syringes in a special (FDA-approved) sharps container.
  • Because Stelara (Ustekinumab) needs to be refrigerated until you use it, if you're traveling, you'll need to carry it in a cooler with an ice pack.
Used for
Dosage forms
  • Injection
  • Injection
Price
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$4537.05
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$9736.36
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Reviews
182 
60%
think this treatment is worth it
51%
think this treatment works well
26%
think this treatment is a hassle

Have you used Humira (adalimumab)?

Leave a review
50 
48%
think this treatment is worth it
42%
think this treatment works well
20%
think this treatment is a hassle

Have you used Stelara (Ustekinumab)?

Leave a review
Side effects
10possible side effects
  • Upper airway infection
    17%
  • Headache
    12%
  • Rash
    12%
  • Sinus infection
    11%
  • Nausea
    9%
  • Injection site reactions
    8%
  • Urinary tract infection
    8%
  • Flu syndrome
    7%
  • Stomach pain
    7%
  • High cholesterol
    7%
See more detailed side effects
1possible side effects
  • Immunogenicity
    6%
See more detailed side effects
Risks and warnings
  • Serious infections

    Taking other immunosuppressant medications such as Kineret or Orencia

    ...and 3 more risk factors

  • Cancers

    Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Humira (adalimumab)

    ...and 3 more risk factors

  • Heart problems

    History of heart failure

  • Nervous system effects

    Preexisting or recently acquired neurologic condition

See more detailed risks and warnings
  • Serious Infections

    Taking other immunosuppressant drugs

    ...and 2 more risk factors

  • Malignancy

    Age 60 or older

    ...and 2 more risk factors

  • Nervous system effects

    Preeclampsia/eclampsia

    ...and 3 more risk factors

See more detailed risks and warnings