Compare hydrochlorothiazide vs. Aldactazide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Microzide
(hydrochlorothiazide )

Aldactazide
(spironolactone / hydrochlorothiazide)

Removes water from the body, which lowers blood pressure. Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.Lowers blood pressure. Removes extra water from your body. Aldactazide (Spironolactone / Hydrochlorothiazide) removes excess fluid in your body and lowers your blood pressure, while helping keep your potassium levels safe.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.48hydrochlorothiazide
Reviews for Microzide (hydrochlorothiazide )
47%
of people (All ages) say Microzide (hydrochlorothiazide ) is worth it
31%
say it works well
16%
say it's a big hassle
139 reviews
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Aldactazide (spironolactone / hydrochlorothiazide)?
Worth itNot sureNot worth it
Side effects
hydrochlorothiazideAldactazide

The hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about hydrochlorothiazide side effects »

We haven’t found good data for Aldactazide side effects.

FDA side effect reports for Aldactazide »
How it works
hydrochlorothiazideAldactazide
Microzide (hydrochlorothiazide (HCTZ)) is a thiazide diuretic (water pill) that makes you urinate more. It works in the kidneys to remove extra water and certain electrolytes, while lowering blood pressure and reducing swelling.Aldactazide (Spironolactone / Hydrochlorothiazide) is a combination medicine that lowers your blood pressure with two diuretics (water pills), hydrochlorothiazide and spironolactone. They act on different parts of your kidney to get rid of extra fluids.
Type of medication
hydrochlorothiazideAldactazide
Prescription only
Prescription only
Available as
hydrochlorothiazideAldactazide
  • Pill
  • Pill
Used for
hydrochlorothiazideAldactazide
Risk factors for serious side effects
hydrochlorothiazideAldactazide
  • Current electrolyte imbalance
  • Lower kidney function
  • Dehydration
  • History of sulfa allergies
  • History of gout
  • Current kidney problems
  • History of sulfa or penicillin allergies
  • Diabetes
Detailed Microzide (hydrochlorothiazide ) risks & warnings »
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
    • Current kidney problems
    • Medicine that affects electrolytes
    • History of sulfa allergies
    • Taking with alcohol
    • Taking other medicines that make you less alert
      Detailed Aldactazide (spironolactone / hydrochlorothiazide) risks & warnings »
      Pregnancy

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Kidneys and liver
      hydrochlorothiazideAldactazide
      • Requires routine blood tests to check kidney function.
      • Needs blood tests to monitor electrolytes and kidney function.
      • Get your blood pressure, potassium, and kidney function checked one week after starting the medicine, then routinely after.
      • Aldactazide (Spironolactone / Hydrochlorothiazide) can increase the amount of potassium in your body. High potassium can cause heart problems. Baseline and routine blood tests are needed to monitor your potassium and kidney function.
      Upsides and benefits
      hydrochlorothiazideAldactazide
      • Does a good job getting rid of extra fluids in your body by making you urinate more.
      • A first-choice blood pressure treatment. Works especially well for people of African descent.
      • Lowers the risk of heart attack and stroke.
      • Good option if you have high blood pressure and heart failure.
      • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
      • Can be good for patients with osteoporosis since it raises the body's level of calcium.
      • Lowers the risk of heart attack and stroke.
      • Has a low risk of causing muscle problems due to low potassium levels in your blood.
      • Gets rid of extra fluids in your body.
      • Helpful for people who tend to have low potassium levels.
      Downsides and risks
      hydrochlorothiazideAldactazide
      • Makes you urinate more often.
      • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
      • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
      • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
      • Many possible side effects, especially when higher doses are used.
      • Can increase the risk of tumor growth.
      • Needs blood tests to monitor electrolytes and kidney function.
      • Can make you urinate more often.
      • Can make you sensitive to sunlight.
      • Shouldn't take it if you have a sulfa allergy.
      Tips from our pharmacists for people taking the medication
      hydrochlorothiazideAldactazide
      • Microzide (hydrochlorothiazide (HCTZ)) starts working in about 2 hours.
      • It makes you urinate more often, so don't take it at bedtime.
      • Can cause dizziness in the first few days.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      • Tell your doctor about any tiredness or muscle weakness that doesn't go away.
      • Requires routine blood tests to check kidney function.
      • Makes you urinate more often, so don't take it at bedtime.
      • Can make you dizzy or cause trouble concentrating, so be careful using it until you know how it affects you.
      • Don't use supplements or salt substitutes that are high in potassium.
      • Get your blood pressure, potassium, and kidney function checked one week after starting the medicine, then routinely after.
      • Tell your doctor about any dizziness, muscle weakness, skin changes, red or black tarry stool.
      • Can make your skin more sensitive to sun, so use proper protections.
      Learn more
      More about hydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Microzide (hydrochlorothiazide )?
      Worth itNot sureNot worth it
      More about AldactazideSide effectsAlternativesFDA package insert
      Have you used Aldactazide (spironolactone / hydrochlorothiazide)?
      Worth itNot sureNot worth it