Compare hydrochlorothiazide vs. Aldactazide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Microzide (hydrochlorothiazide)

Prescription only
Removes water from the body, which lowers blood pressure.

Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.

4.5/ 7 average rating with 139 reviewsforhydrochlorothiazide
Lowers blood pressure. Removes extra water from your body.

Aldactazide (Spironolactone / Hydrochlorothiazide) removes excess fluid in your body and lowers your blood pressure, while helping keep your potassium levels safe.

Upsides
  • Does a good job getting rid of extra fluids in your body by making you urinate more.
  • A first-choice blood pressure treatment. Works especially well for people of African descent.
  • Lowers the risk of heart attack and stroke.
  • Good option if you have high blood pressure and heart failure.
  • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
  • Can be good for patients with osteoporosis since it raises the body's level of calcium.
  • Lowers the risk of heart attack and stroke.
  • Has a low risk of causing muscle problems due to low potassium levels in your blood.
  • Gets rid of extra fluids in your body.
  • Helpful for people who tend to have low potassium levels.
Downsides
  • Makes you urinate more often.
  • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
  • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
  • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
  • Many possible side effects, especially when higher doses are used.
  • Can increase the risk of tumor growth.
  • Needs blood tests to monitor electrolytes and kidney function.
  • Can make you urinate more often.
  • Can make you sensitive to sunlight.
  • Shouldn't take it if you have a sulfa allergy.
Used for
Dosage forms
  • Pill
  • Pill
Price
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$4
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$68.4
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Reviews
139 
47%
think this treatment is worth it
31%
think this treatment works well
16%
think this treatment is a hassle

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Side effects
The Microzide (hydrochlorothiazide (HCTZ)) FDA package insert doesn’t have numbers about how common side effects are.
The Aldactazide (Spironolactone / Hydrochlorothiazide) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Dehydration and electrolyte imbalance

    Current electrolyte imbalance

    ...and 2 more risk factors

  • Severe allergic reactions

    History of sulfa allergies

  • Gout

    History of gout

    ...and 1 more risk factors

  • Vision problems

    History of sulfa or penicillin allergies

  • Higher blood sugars

    Diabetes

See more detailed risks and warnings
  • Heart problems due to high potassium

    Current kidney problems

    ...and 2 more risk factors

  • Muscle problems due to electrolyte imbalance

    Current kidney problems

    ...and 1 more risk factors

  • Severe allergic reactions

    History of sulfa allergies

  • Driving impairment

    Taking with alcohol

    ...and 1 more risk factors

See more detailed risks and warnings