Compare Hydrochlorothiazide vs. Aldactazide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Microzide
(Hydrochlorothiazide )

Aldactazide
(Spironolactone / Hydrochlorothiazide)

Lowers blood pressure. Removes extra water from your body. Microzide (Hydrochlorothiazide (Hctz)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.Lowers blood pressure. Removes extra water from your body. Aldactazide (Spironolactone / Hydrochlorothiazide) removes excess fluid in your body and lowers your blood pressure, while helping keep your potassium levels safe.
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Reviews & ratings
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4.467153284671533Hydrochlorothiazide
Reviews for Microzide (Hydrochlorothiazide (Hctz))
47%
of people say Microzide (Hydrochlorothiazide (Hctz)) is worth it
31%
say it works well
15%
say it's a big hassle

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Side effects
HydrochlorothiazideAldactazide

The Hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about Hydrochlorothiazide side effects »

We haven’t found good data for Aldactazide side effects.

FDA side effect reports for Aldactazide »
How it works
HydrochlorothiazideAldactazide
Microzide (Hydrochlorothiazide (Hctz)) is a thiazide diuretic (water pill). It works in the kidneys to make you urinate more, which removes extra water and certain electrolytes. This lowers blood pressure and swelling.Aldactazide (Spironolactone / Hydrochlorothiazide) is a combination medicine that lowers your blood pressure with two diuretics (water pills), hydrochlorothiazide and spironolactone. They act on different parts of your kidney to get rid of extra fluids.
Type of medication
HydrochlorothiazideAldactazide
Antihypertensive
Diuretic
Prescription only
Antihypertensive
Diuretic
Diuretic
Prescription only
Available as
HydrochlorothiazideAldactazide
  • Pill
  • Pill
Used for (click to learn more)
HydrochlorothiazideAldactazide
Risk factors for serious side effects
HydrochlorothiazideAldactazide
  • Current electrolyte imbalance
  • History of sulfa allergies
  • History of gout
  • Current kidney problems
    Detailed Microzide (Hydrochlorothiazide (Hctz)) risks & warnings »
      • Current kidney problems
      • Medicine that increase potassium
      • Use of salt substitute
      • Current kidney problems
      • Medicine that affects electrolytes
      • History of sulfa allergies
      • Taking with alcohol
      • Taking other medicines that make you less alert
        Detailed Aldactazide (Spironolactone / Hydrochlorothiazide) risks & warnings »
        Pregnancy category
        HydrochlorothiazideAldactazide
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.
        Food
        No specific food-related info.No specific food-related info.
        Kidneys and liver
        • Doesn't work well in people with severe kidney problems.
        • Requires routine blood tests to check kidney function.
        • Needs blood tests to monitor electrolytes and kidney function.
        • Get your blood pressure, potassium, and kidney function checked one week after starting the medicine, then routinely after.
        • Aldactazide (Spironolactone / Hydrochlorothiazide) can increase the amount of potassium in your body. High potassium can cause heart problems. Baseline and routine blood tests are needed to monitor your potassium and kidney function.
        • Aldactazide (Spironolactone / Hydrochlorothiazide) can affect levels of certain electrolytes (sodium, magnesium) that can cause muscle weakness/spasms or unexplained tiredness. Baseline and routine blood tests are needed to monitor your electrolytes and kidney function.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        HydrochlorothiazideAldactazide
        • Works well to get rid of extra fluids in your body through urination.
        • A first-choice blood pressure treatment for many people. Works especially well for African Americans.
        • Good option if you have both high blood pressure and heart failure.
        • Raises calcium levels in the body, so it can be good for people with osteoporosis to slow down bone loss and even help with new bone formation.
        • Most people have very few side effects.
        • Lowers the risk of heart attack and stroke.
        • Has a low risk of causing muscle problems due to low potassium levels in your blood.
        • Gets rid of extra fluids in your body.
        • Helpful for people who tend to have low potassium levels.
        • Lowers the risk of heart attack and stroke.
        Downsides and risks
        HydrochlorothiazideAldactazide
        • Makes you urinate more often.
        • Doesn't work well in people with severe kidney problems.
        • Many possible side effects, especially when higher doses are used.
        • Can increase the risk of tumor growth.
        • Needs blood tests to monitor electrolytes and kidney function.
        • Can make you urinate more often.
        • Can make you sensitive to sunlight.
        • Shouldn't take it if you have a sulfa allergy.
        Tips from our pharmacists for people taking the medication
        HydrochlorothiazideAldactazide
        • Starts working in about 2 hours.
        • Makes you urinate more often, so avoid taking it at bedtime.
        • Can cause dizziness in the first few days.
        • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
        • Tell your doctor about any dizziness, fatigue, or muscle weakness that doesn't go away.
        • Requires routine blood tests to check kidney function.
        • Makes you urinate more often, so don't take it at bedtime.
        • Can make you dizzy or cause trouble concentrating, so be careful using it until you know how it affects you.
        • Don't use supplements or salt substitutes that are high in potassium.
        • Get your blood pressure, potassium, and kidney function checked one week after starting the medicine, then routinely after.
        • Tell your doctor about any dizziness, muscle weakness, skin changes, red or black tarry stool.
        • Can make your skin more sensitive to sun, so use proper protections.
        Learn more
        More about HydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
        More about AldactazideSide effectsAlternativesFDA package insert