Compare hydrochlorothiazide vs. benazepril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Microzide
(hydrochlorothiazide )

Lotensin
(benazepril)

Removes water from the body, which lowers blood pressure. Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.Lowers blood pressure. Lotensin (benazepril) is a good blood pressure-lowering medicine that also protects kidney function.
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Reviews & ratings
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4.48hydrochlorothiazide
Reviews for Microzide (hydrochlorothiazide )
47%
of people (All ages) say Microzide (hydrochlorothiazide ) is worth it
31%
say it works well
16%
say it's a big hassle
139 reviews
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it
Reviews for Lotensin (benazepril)
61%
+14% better vs. Microzide (hydrochlorothiazide )
64%
+33% better vs. Microzide (hydrochlorothiazide )
23%
-7% worse vs. Microzide (hydrochlorothiazide )
Have you used Lotensin (benazepril)?
Worth itNot sureNot worth it
Side effects
hydrochlorothiazidebenazepril

The hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about hydrochlorothiazide side effects »
  • Headache 2%
  • Dizziness 2%
  • Drowsiness 2%
  • Dizziness when standing up 2%
More benazepril side effects »
How it works
hydrochlorothiazidebenazepril
Microzide (hydrochlorothiazide (HCTZ)) is a thiazide diuretic (water pill) that makes you urinate more. It works in the kidneys to remove extra water and certain electrolytes, while lowering blood pressure and reducing swelling.Lotensin (benazepril) is an angiotensin converting enzyme (ACE) inhibitor. It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.
Type of medication
hydrochlorothiazidebenazepril
Prescription only
Prescription only
Available as
hydrochlorothiazidebenazepril
  • Pill
  • Pill
Used for
hydrochlorothiazidebenazepril
Risk factors for serious side effects
hydrochlorothiazidebenazepril
  • Current electrolyte imbalance
  • Lower kidney function
  • Dehydration
  • History of sulfa allergies
  • History of gout
  • Current kidney problems
  • History of sulfa or penicillin allergies
  • Diabetes
Detailed Microzide (hydrochlorothiazide ) risks & warnings »
  • Women of childbearing age
  • Infants less than one year old
  • African descent
  • Taking with alcohol
  • Taking other medicines that lower your blood pressure
    • Current kidney problems
    • Taking other medicines that increase potassium
    • Using salt substitutes
    • Kidney disease
    Detailed Lotensin (benazepril) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Interactions
    hydrochlorothiazidebenazepril
    No interactions related info.
    • This drug interacts with other medications that affect potassium, so it needs to be dosed carefully.
    Kidneys and liver
    hydrochlorothiazidebenazepril
    • Requires routine blood tests to check kidney function.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    Upsides and benefits
    hydrochlorothiazidebenazepril
    • Does a good job getting rid of extra fluids in your body by making you urinate more.
    • A first-choice blood pressure treatment. Works especially well for people of African descent.
    • Lowers the risk of heart attack and stroke.
    • Good option if you have high blood pressure and heart failure.
    • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
    • Can be good for patients with osteoporosis since it raises the body's level of calcium.
    • A first-choice blood pressure treatment for many people.
    • Lowers the risk of heart attack and stroke.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    Downsides and risks
    hydrochlorothiazidebenazepril
    • Makes you urinate more often.
    • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
    • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
    • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
    • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
    • Requires a regular blood test to see how the medicine is affecting your body.
    • Not safe to use if you're pregnant.
    • This drug interacts with other medications that affect potassium, so it needs to be dosed carefully.
    Tips from our pharmacists for people taking the medication
    hydrochlorothiazidebenazepril
    • Microzide (hydrochlorothiazide (HCTZ)) starts working in about 2 hours.
    • It makes you urinate more often, so don't take it at bedtime.
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Tell your doctor about any tiredness or muscle weakness that doesn't go away.
    • Requires routine blood tests to check kidney function.
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it doesn't get better.
    • Tell your doctor about any tiredness, cough, mouth swelling, or throat irritation that doesn't go away.
    • Requires blood tests to check potassium levels and kidney function.
    • Don't take it if you're pregnant.
    Learn more
    More about hydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Microzide (hydrochlorothiazide )?
    Worth itNot sureNot worth it
    More about benazeprilSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Lotensin (benazepril)?
    Worth itNot sureNot worth it