Compare hydrochlorothiazide vs. Catapres

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Microzide
(hydrochlorothiazide )

Catapres
(clonidine)

Removes water from the body, which lowers blood pressure. Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.Lowers blood pressure. Catapres (Clonidine) is a good addition if you need more than one medicine to control your blood pressure, but it has a lot of side effects. You can't miss doses.
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Best available price for 30 (12.5mg) capsules of hydrochlorothiazide
Coupons for Catapres
Best available price for 60 (0.1mg) tablets of clonidine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.48hydrochlorothiazide
Reviews for hydrochlorothiazide
47%
of people (All ages) say hydrochlorothiazide is worth it
31%
say it works well
16%
say it's a big hassle
139 reviews
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it
Reviews for Catapres
42%
+5% better vs. hydrochlorothiazide
33%
-2% worse vs. hydrochlorothiazide
35%
+19% better vs. hydrochlorothiazide
Have you used Catapres (clonidine)?
Worth itNot sureNot worth it
Side effects
hydrochlorothiazideCatapres

The hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about hydrochlorothiazide side effects »
  • Redness/itching / pruritis 26%
  • Dry mouth 25%
  • Drowsiness 12%
  • Skin blistering 7%
  • Fatigue 6%
  • Headache 5%
  • Skin or nail darkening 5%
  • Allergic contact sensitization 5%
  • Burning 3%
  • Lack of energy 3%
More Catapres side effects »
How it works
hydrochlorothiazideCatapres
Microzide (hydrochlorothiazide (HCTZ)) is a thiazide diuretic (water pill) that makes you urinate more. It works in the kidneys to remove extra water and certain electrolytes, while lowering blood pressure and reducing swelling.Catapres (Clonidine) is an alpha-2 agonist. It works in the brain to tell your blood vessels to relax, and it lowers the activity of certain stress hormones. This lowers blood pressure.
Type of medication
hydrochlorothiazideCatapres
Prescription onlyPrescription only
Available as
hydrochlorothiazideCatapres
  • Pill
  • Pill
  • Extended release
  • Patch
Used for
hydrochlorothiazideCatapres
Risk factors for serious side effects
hydrochlorothiazideCatapres
  • Current electrolyte imbalance
  • Lower kidney function
  • Dehydration
  • History of sulfa allergies
  • History of gout
Detailed Microzide (hydrochlorothiazide ) risks & warnings »
  • Sudden discontinuation of medicine
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 years or older
  • Using other medicine(s) that slows the heart
Detailed Catapres (clonidine) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
hydrochlorothiazideCatapres
  • Requires routine blood tests to check kidney function.
No kidneys and liver related info.
Sleep
hydrochlorothiazideCatapres
No sleep related info.
  • Can cause drowsiness, headache, dizziness, and dry mouth.
Upsides and benefits
hydrochlorothiazideCatapres
  • Does a good job getting rid of extra fluids in your body by making you urinate more.
  • A first-choice blood pressure treatment. Works especially well for people of African descent.
  • Lowers the risk of heart attack and stroke.
  • Good option if you have high blood pressure and heart failure.
  • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
  • Can be good for patients with osteoporosis since it raises the body's level of calcium.
  • Can be added to other blood pressure-lowering medicines if you need additional blood pressure control.
  • Available in a weekly patch for people that aren't good at taking medicine by mouth.
  • Works in the brain, so it can help treat some nervous system and psychiatric conditions.
  • Under the brand name Kapvay, it's used to treat ADHD in children and teenagers.
Downsides and risks
hydrochlorothiazideCatapres
  • Makes you urinate more often.
  • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
  • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
  • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
  • Has a lot of side effects compared to other blood pressure-lowering medicine because it works in the brain.
  • The pill form can make some people sleepy, dizzy, and have dry mouth.
  • You can't miss doses. Stopping Clonidine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
Tips from our pharmacists for people taking the medication
hydrochlorothiazideCatapres
  • Microzide (hydrochlorothiazide (HCTZ)) starts working in about 2 hours.
  • It makes you urinate more often, so don't take it at bedtime.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Tell your doctor about any tiredness or muscle weakness that doesn't go away.
  • Requires routine blood tests to check kidney function.
  • Usually taken together with other medicines for better blood pressure control.
  • Can cause drowsiness, headache, dizziness, and dry mouth.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • If side effects don't go away, talk to your doctor about alternatives.
  • The weekly patch form can have fewer side effects.
  • Don't stop taking this medicine suddenly.
  • Extended release tablet also used to treat ADHD.
Learn more
More about hydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it
More about CatapresSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Catapres (clonidine)?
Worth itNot sureNot worth it