Compare hydrochlorothiazide vs. digoxin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Lanoxin (digoxin)

Prescription only
Removes water from the body, which lowers blood pressure.

Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.

3.3/ 5 average rating with 139 reviewsforhydrochlorothiazide
Improves heart pumping.

Lanoxin (digoxin) is effective at treating heart failure symptoms, but it doesn't lower your risk of death compared to other heart failure medicines.

3.3/ 5 average rating with 70 reviewsfordigoxin
Upsides
  • Does a good job getting rid of extra fluids in your body by making you urinate more.
  • A first-choice blood pressure treatment. Works especially well for people of African descent.
  • Lowers the risk of heart attack and stroke.
  • Good option if you have high blood pressure and heart failure.
  • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
  • Can be good for patients with osteoporosis since it raises the body's level of calcium.
  • Lanoxin (digoxin) is used for abnormal heart rhythms, and for heart failure that can't be controlled by other medications.
  • Lanoxin (digoxin) does not need dose adjustments with people with liver problems.
  • Lanoxin (digoxin) is available in a generic form.
  • Lanoxin (digoxin) can be taken once daily.
Downsides
  • Makes you urinate more often.
  • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
  • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
  • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
  • Lanoxin (digoxin) relieves heart failure symptoms, but doesn't lower your risk of death. It's usually used together with other medicines that help lower the risk of death in heart failure.
  • Use of Lanoxin (digoxin) requires blood tests, especially during the first few weeks of treatment to monitor drug level in the body.
  • If your blood levels of Lanoxin (digoxin) are too high, it can be life threatening.
  • Lanoxin (digoxin) is usually not an option for people with kidney problems.
Used for
Dosage forms
  • Pill
  • Pill
  • Liquid
Price
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Reviews
139 reviews so far
47%
saidit'sworth it
31%
saiditworked well
16%
saidit'sa big hassle

Have you used Microzide (hydrochlorothiazide (HCTZ))?

Leave a review
70 reviews so far
64%
saidit'sworth it
43%
saiditworked well
31%
saidit'sa big hassle

Have you used Lanoxin (digoxin)?

Leave a review
Side effects
The Microzide (hydrochlorothiazide (HCTZ)) FDA package insert doesn’t have numbers about how common side effects are.
9possible side effects
  • Dizziness
    5%
  • Mental disturbances
    4%
  • Nausea
    3%
  • Diarrhea
    3%
  • Headache
    3%
  • Death
    3%
  • Increased heart rate
    2%
  • Vomiting
    2%
  • Rash
    2%
See more detailed side effects
Risks and risk factors
  • Dehydration and electrolyte imbalance
    • Current electrolyte imbalance
    • Lower kidney function
    • Dehydration
  • Severe allergic reactions
    • History of sulfa allergies
  • Gout
    • History of gout
    • Current kidney problems
  • Vision problems
    • History of sulfa or penicillin allergies
  • Higher blood sugars
    • Diabetes
See more detailed risks and warnings
  • Irregular heartbeat
    • History of heart problems
    • Drug interactions
    • Wolff-Parkinson-White syndrome
  • Digoxin toxicity
    • Low body weight
    • Elderly (>65 years old)
    • Worsening kidney function
    • Electrolyte imbalances
  • Thyroid imbalance
    • Overactive or underactive thyroid
See more detailed risks and warnings