Compare Hydrochlorothiazide vs. Digoxin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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(Hydrochlorothiazide )


Lowers blood pressure. Removes extra water from your body. Microzide (Hydrochlorothiazide (Hctz)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.Improves heart pumping. Digoxin is a good backup for treating heart failure symptoms, but it doesn't, by itself, lower your risk of death.
How it works
Microzide (Hydrochlorothiazide (Hctz)) is a thiazide diuretic (water pill). It works in the kidneys to make you urinate more, which removes extra water and certain electrolytes. This lowers blood pressure and swelling.Digoxin helps your heart work more efficiently. It makes your heart pump slower and stronger, which helps it get more blood and oxygen out to your body and organs.
Type of medication
Prescription only
Prescription only
Available as
  • Pill
  • Pill
  • Liquid
Used for (click to learn more)
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Reviews & ratings
Button Group. All currently active
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Reviews for Microzide (Hydrochlorothiazide (Hctz))
of people say Microzide (Hydrochlorothiazide (Hctz)) is worth it
say it works well
say it's a big hassle
Reviews for Lanoxin (Digoxin)
+17% vs. Microzide (Hydrochlorothiazide (Hctz))
+12% vs. Microzide (Hydrochlorothiazide (Hctz))
16% vs. Microzide (Hydrochlorothiazide (Hctz))
Side effects

The Hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about Hydrochlorothiazide side effects »
  • Dizziness 1%
  • Side effects requiring hospitalization 1%
  • Nausea 1%
  • Death 1%
More Digoxin side effects »
Risk factors for serious side effects
  • Current electrolyte imbalance
  • History of sulfa allergies
  • History of gout
  • Current kidney problems
    Detailed Microzide (Hydrochlorothiazide (Hctz)) risks & warnings »
    • History of heart problems
    • Drug interactions
    • Wolff-Parkinson-White syndrome
    • Low body weight, advanced age, impaired renal function, electrolyte imbalances
    • Overactive or underactive thyroid
    • Aspirin allergy
    • Electrocardioversion
    Detailed Lanoxin (Digoxin) risks & warnings »
    Pregnancy category
    BFDA pregnancy category (Probably safe)

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    No specific alcohol-related info.No specific alcohol-related info.
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    • Doesn't work well in people with severe kidney problems.
    • Requires routine blood tests to check kidney function.
    No specific kidneys and liver-related info.
    No specific sex-related info.No specific sex-related info.
    No specific sleep-related info.No specific sleep-related info.
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    • Works well to get rid of extra fluids in your body through urination.
    • A first-choice blood pressure treatment for many people. Works especially well for African Americans.
    • Lowers the risk of heart attack and stroke.
    • Good option if you have both high blood pressure and heart failure.
    • Raises calcium levels in the body, so it can be good for people with osteoporosis to slow down bone loss and even help with new bone formation.
    • Most people have very few side effects.
    • Used for some abnormal heart rhythms, and for heart failure that can't be controlled by other medications.
    • Relieves shortness of breath, and makes it easier to be active without having symptoms.
    • In studies, Digoxin lowered the risk of having to be admitted to the hospital for worsening heart failure.
    Downsides and risks
    • Makes you urinate more often.
    • Doesn't work well in people with severe kidney problems.
    • For heart failure, relieves symptoms, but does not lower the risk of death. That's why it's usually used together with other heart failure medicines that do lower the risk of death.
    • Requires blood tests, especially during the first few weeks of treatment.
    Tips from our pharmacists for people taking the medication
    • Starts working in about 2 hours.
    • Makes you urinate more often, so avoid taking it at bedtime.
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Tell your doctor about any dizziness, fatigue, or muscle weakness that doesn't go away.
    • Requires routine blood tests to check kidney function.
    • Take it at the same time every day.
    • Drink plenty of water while taking this medicine.
    • Requires routine blood tests to make sure you have the right amount of Digoxin in your body.
    • Tell your doctor about other medicines you're taking to avoid drug interactions.
    Learn more
    More about HydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
    More about DigoxinSide effectsReviews & ratingsAlternativesFDA package insert