Compare hydrochlorothiazide vs. Digoxin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Microzide
(hydrochlorothiazide )

Lanoxin
(digoxin)

Removes water from the body, which lowers blood pressure. Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.Improves heart pumping. Digoxin is a good backup for treating heart failure symptoms, but it doesn't, by itself, lower your risk of death.
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Best available price for 30 (12.5mg) capsules of hydrochlorothiazide
Coupons for Digoxin
Best available price for 30 (125mcg) tablets of digoxin
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.48hydrochlorothiazide
Reviews for hydrochlorothiazide
47%
of people (All ages) say hydrochlorothiazide is worth it
31%
say it works well
16%
say it's a big hassle
139 reviews
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it
Reviews for Digoxin
64%
-17% worse vs. hydrochlorothiazide
43%
-12% worse vs. hydrochlorothiazide
31%
+15% better vs. hydrochlorothiazide
Have you used Lanoxin (digoxin)?
Worth itNot sureNot worth it
Side effects
hydrochlorothiazideDigoxin

The hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about hydrochlorothiazide side effects »
  • Any side effect 20%
  • Dizziness 1%
  • Mental disturbances 4%
  • Nausea 1%
  • Diarrhea 3%
  • Death 1%
  • Side effects requiring hospitalization 1%
  • Abnormally fast heart beat 2%
  • Vomiting 2%
More Digoxin side effects »
How it works
hydrochlorothiazideDigoxin
Microzide (hydrochlorothiazide (HCTZ)) is a thiazide diuretic (water pill) that makes you urinate more. It works in the kidneys to remove extra water and certain electrolytes, while lowering blood pressure and reducing swelling.Digoxin helps your heart work more efficiently. It makes your heart pump slower and stronger, which helps it get more blood and oxygen out to your body and organs.
Type of medication
hydrochlorothiazideDigoxin
Prescription onlyPrescription only
Available as
hydrochlorothiazideDigoxin
  • Pill
  • Pill
  • Liquid
Used for
hydrochlorothiazideDigoxin
Risk factors for serious side effects
hydrochlorothiazideDigoxin
  • Current electrolyte imbalance
  • Lower kidney function
  • Dehydration
  • History of sulfa allergies
  • History of gout
Detailed Microzide (hydrochlorothiazide ) risks & warnings »
  • History of heart problems
  • Drug interactions
  • Wolff-Parkinson-White syndrome
  • Low body weight, advanced age, impaired renal function, electrolyte imbalances
  • Overactive or underactive thyroid
Detailed Lanoxin (digoxin) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
hydrochlorothiazideDigoxin
No interactions related info.
  • Tell your doctor about other medicines you're taking to avoid drug interactions.
Kidneys and liver
hydrochlorothiazideDigoxin
  • Requires routine blood tests to check kidney function.
No kidneys and liver related info.
Upsides and benefits
hydrochlorothiazideDigoxin
  • Does a good job getting rid of extra fluids in your body by making you urinate more.
  • A first-choice blood pressure treatment. Works especially well for people of African descent.
  • Lowers the risk of heart attack and stroke.
  • Good option if you have high blood pressure and heart failure.
  • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
  • Can be good for patients with osteoporosis since it raises the body's level of calcium.
  • Used for some abnormal heart rhythms, and for heart failure that can't be controlled by other medications.
  • Relieves shortness of breath, and makes it easier to be active without having symptoms.
  • In studies, Digoxin lowered the risk of having to be admitted to the hospital for worsening heart failure.
Downsides and risks
hydrochlorothiazideDigoxin
  • Makes you urinate more often.
  • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
  • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
  • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
  • For heart failure, relieves symptoms, but does not lower the risk of death. That's why it's usually used together with other heart failure medicines that do lower the risk of death.
  • Requires blood tests, especially during the first few weeks of treatment.
Tips from our pharmacists for people taking the medication
hydrochlorothiazideDigoxin
  • Microzide (hydrochlorothiazide (HCTZ)) starts working in about 2 hours.
  • It makes you urinate more often, so don't take it at bedtime.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Tell your doctor about any tiredness or muscle weakness that doesn't go away.
  • Requires routine blood tests to check kidney function.
  • Take it at the same time every day.
  • Drink plenty of water while taking this medicine.
  • Requires routine blood tests to make sure you have the right amount of Digoxin in your body.
  • Tell your doctor about other medicines you're taking to avoid drug interactions.
Learn more
More about hydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it
More about DigoxinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lanoxin (digoxin)?
Worth itNot sureNot worth it