Compare hydrochlorothiazide vs. Diovan HCT

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Microzide
(hydrochlorothiazide )

Diovan Hct
(valsartan / hydrochlorothiazide)

Removes water from the body, which lowers blood pressure. Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.Lowers blood pressure. Diovan Hct (Valsartan / Hydrochlorothiazide) is a good 2-in-1 blood pressure-lowering medicine that protects kidney function like an ACE inhibitor, but with fewer side effects.
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Reviews & ratings
Filter group. All currently selected
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4.48hydrochlorothiazide
Reviews for Microzide (hydrochlorothiazide )
47%
of people (All ages) say Microzide (hydrochlorothiazide ) is worth it
31%
say it works well
16%
say it's a big hassle
139 reviews
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it
Reviews for Diovan Hct (valsartan / hydrochlorothiazide)
63%
+16% better vs. Microzide (hydrochlorothiazide )
52%
+21% better vs. Microzide (hydrochlorothiazide )
19%
-3% worse vs. Microzide (hydrochlorothiazide )
412 reviews
Have you used Diovan Hct (valsartan / hydrochlorothiazide)?
Worth itNot sureNot worth it
Side effects
hydrochlorothiazideDiovan HCT

The hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about hydrochlorothiazide side effects »
  • Dizziness 4%
More Diovan HCT side effects »
How it works
hydrochlorothiazideDiovan HCT
Microzide (hydrochlorothiazide (HCTZ)) is a thiazide diuretic (water pill) that makes you urinate more. It works in the kidneys to remove extra water and certain electrolytes, while lowering blood pressure and reducing swelling.Diovan Hct (Valsartan / Hydrochlorothiazide) is a combination medicine. Valsartan (an angiotensin receptor blocker) lowers blood pressure by making blood vessels relax. Hydrochlorothiazide (a diuretic or water pill) lowers blood pressure and swelling by removing extra fluid from your body.
Type of medication
hydrochlorothiazideDiovan HCT
Prescription only
Prescription only
Available as
hydrochlorothiazideDiovan HCT
  • Pill
  • Pill
Used for
hydrochlorothiazideDiovan HCT
Risk factors for serious side effects
hydrochlorothiazideDiovan HCT
  • Current electrolyte imbalance
  • Lower kidney function
  • Dehydration
  • History of sulfa allergies
  • History of gout
  • Current kidney problems
  • History of sulfa or penicillin allergies
  • Diabetes
Detailed Microzide (hydrochlorothiazide ) risks & warnings »
  • Women of childbearing age
  • African descent
  • History of kidney disease
  • History of lupus
  • Taking lithium
  • Allergies to penicillin or sulfonamides
  • History of gout
  • Current kidney problems
  • History of liver disease
Detailed Diovan Hct (valsartan / hydrochlorothiazide) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
hydrochlorothiazideDiovan HCT
  • Requires routine blood tests to check kidney function.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Requires routine blood tests to check kidney function.
  • Diovan Hct (Valsartan / Hydrochlorothiazide) can cause kidney damage, especially if you already have a history of kidney disease. Talk to your doctor to discuss possible alternatives if this is a concern.
Upsides and benefits
hydrochlorothiazideDiovan HCT
  • Does a good job getting rid of extra fluids in your body by making you urinate more.
  • A first-choice blood pressure treatment. Works especially well for people of African descent.
  • Lowers the risk of heart attack and stroke.
  • Good option if you have high blood pressure and heart failure.
  • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
  • Can be good for patients with osteoporosis since it raises the body's level of calcium.
  • Combination medicine for people with high blood pressure. Doctors might prescribe it when you need more than one medicine to control your blood pressure.
  • The two drugs in Diovan HCT work together to lower blood pressure and remove extra water from your body.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
Downsides and risks
hydrochlorothiazideDiovan HCT
  • Makes you urinate more often.
  • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
  • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
  • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
  • Comes in fixed dosage strengths, so it's harder for your doctor to adjust your dose.
  • Makes you urinate more often.
  • Doesn't work as well in people with severe kidney problems.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
Tips from our pharmacists for people taking the medication
hydrochlorothiazideDiovan HCT
  • Microzide (hydrochlorothiazide (HCTZ)) starts working in about 2 hours.
  • It makes you urinate more often, so don't take it at bedtime.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Tell your doctor about any tiredness or muscle weakness that doesn't go away.
  • Requires routine blood tests to check kidney function.
  • Makes you urinate more often, so avoid taking it at bedtime.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
  • Requires routine blood tests to check kidney function.
  • Don't take it if you're pregnant.
Learn more
More about hydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it
More about Diovan HCTSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Diovan Hct (valsartan / hydrochlorothiazide)?
Worth itNot sureNot worth it