Compare Hydrochlorothiazide vs. Diovan HCT

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Microzide
(Hydrochlorothiazide )

Diovan Hct
(Valsartan / Hydrochlorothiazide)

Lowers blood pressure. Removes extra water from your body. Microzide (Hydrochlorothiazide (Hctz)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.Lowers blood pressure. Diovan Hct (Valsartan / Hydrochlorothiazide) is a good 2-in-1 blood pressure-lowering medicine that protects kidney function like an ACE inhibitor, but with fewer side effects.
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Reviews & ratings
Button Group. All currently active
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4.467153284671533Hydrochlorothiazide
Reviews for Microzide (Hydrochlorothiazide (Hctz))
47%
of people say Microzide (Hydrochlorothiazide (Hctz)) is worth it
31%
say it works well
15%
say it's a big hassle
Reviews for Diovan Hct (Valsartan / Hydrochlorothiazide)
63%
+16% vs. Microzide (Hydrochlorothiazide (Hctz))
52%
+21% vs. Microzide (Hydrochlorothiazide (Hctz))
19%
4% vs. Microzide (Hydrochlorothiazide (Hctz))
Side effects
HydrochlorothiazideDiovan HCT

The Hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about Hydrochlorothiazide side effects »
  • Dizziness 4%
More Diovan HCT side effects »
How it works
HydrochlorothiazideDiovan HCT
Microzide (Hydrochlorothiazide (Hctz)) is a thiazide diuretic (water pill). It works in the kidneys to make you urinate more, which removes extra water and certain electrolytes. This lowers blood pressure and swelling.Diovan Hct (Valsartan / Hydrochlorothiazide) is a combination medicine. Valsartan (an angiotensin receptor blocker) lowers blood pressure by making blood vessels relax. Hydrochlorothiazide (a diuretic or water pill) lowers blood pressure and swelling by removing extra fluid from your body.
Type of medication
HydrochlorothiazideDiovan HCT
Antihypertensive
Diuretic
Prescription only
Antihypertensive
Angiotensin receptor blocker
Diuretic
Prescription only
Available as
HydrochlorothiazideDiovan HCT
  • Pill
  • Pill
Used for (click to learn more)
HydrochlorothiazideDiovan HCT
Risk factors for serious side effects
HydrochlorothiazideDiovan HCT
  • Current electrolyte imbalance
  • History of sulfa allergies
  • History of gout
  • Current kidney problems
    Detailed Microzide (Hydrochlorothiazide (Hctz)) risks & warnings »
    • Women of childbearing age
    • African descent
    • History of kidney disease
    • History of lupus
    • Taking lithium
    • Allergies to penicillin or sulfonamides
    • History of gout
    • Current kidney problems
    • History of liver disease
    Detailed Diovan Hct (Valsartan / Hydrochlorothiazide) risks & warnings »
    Pregnancy category
    HydrochlorothiazideDiovan HCT
    BFDA pregnancy category (Probably safe)

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    See the FDA package insert
    DFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.
    Food
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    • Doesn't work well in people with severe kidney problems.
    • Requires routine blood tests to check kidney function.
    • Doesn't work as well in people with severe kidney problems.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Requires routine blood tests to check kidney function.
    • Diovan Hct (Valsartan / Hydrochlorothiazide) can cause kidney damage, especially if you already have a history of kidney disease. Talk to your doctor to discuss possible alternatives if this is a concern.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    HydrochlorothiazideDiovan HCT
    • Works well to get rid of extra fluids in your body through urination.
    • A first-choice blood pressure treatment for many people. Works especially well for African Americans.
    • Good option if you have both high blood pressure and heart failure.
    • Raises calcium levels in the body, so it can be good for people with osteoporosis to slow down bone loss and even help with new bone formation.
    • Most people have very few side effects.
    • Lowers the risk of heart attack and stroke.
    • Combination medicine for people with high blood pressure. Doctors might prescribe it when you need more than one medicine to control your blood pressure.
    • The two drugs in Diovan HCT work together to lower blood pressure and remove extra water from your body.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
    • Lowers the risk of heart attack and stroke.
    Downsides and risks
    HydrochlorothiazideDiovan HCT
    • Doesn't work well in people with severe kidney problems.
    • Makes you urinate more often.
    • Comes in fixed dosage strengths, so it's harder for your doctor to adjust your dose.
    • Doesn't work as well in people with severe kidney problems.
    • Requires a yearly blood test to see how the medicine is affecting your body.
    • Not safe to use if you're pregnant.
    • Makes you urinate more often.
    Tips from our pharmacists for people taking the medication
    HydrochlorothiazideDiovan HCT
    • Starts working in about 2 hours.
    • Tell your doctor about any dizziness, fatigue, or muscle weakness that doesn't go away.
    • Makes you urinate more often, so avoid taking it at bedtime.
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Requires routine blood tests to check kidney function.
    • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
    • Don't take it if you're pregnant.
    • Makes you urinate more often, so avoid taking it at bedtime.
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Requires routine blood tests to check kidney function.
    Learn more
    More about HydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
    More about Diovan HCTSide effectsReviews & ratingsAlternativesFDA package insert