Compare hydrochlorothiazide vs. Dutoprol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Microzide
(hydrochlorothiazide )

Dutoprol
(metoprolol succinate / hydrochlorothiazide)

Removes water from the body, which lowers blood pressure. Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.Lowers blood pressure. Dutoprol (Metoprolol Succinate / Hydrochlorothiazide) helps lower blood pressure by working in two different ways in your body. It's good for stubbornly high blood pressure.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.48hydrochlorothiazide
Reviews for hydrochlorothiazide
47%
of people (All ages) say hydrochlorothiazide is worth it
31%
say it works well
16%
say it's a big hassle
139 reviews
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Dutoprol (metoprolol succinate / hydrochlorothiazide)?
Worth itNot sureNot worth it
Side effects
hydrochlorothiazideDutoprol

The hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about hydrochlorothiazide side effects »
  • Nasopharyngitis 2%
  • Fatigue 2%
  • Back pain 1%
More Dutoprol side effects »
How it works
hydrochlorothiazideDutoprol
Microzide (hydrochlorothiazide (HCTZ)) is a thiazide diuretic (water pill) that makes you urinate more. It works in the kidneys to remove extra water and certain electrolytes, while lowering blood pressure and reducing swelling.Dutoprol (Metoprolol Succinate / Hydrochlorothiazide) is a combination medicine that helps control your blood pressure and reduce the risk of a heart attack or stroke. Hydrochlorothiazide is a diuretic that removes extra water from your body. Metoprolol is a beta blocker that lowers your heart rate.
Type of medication
hydrochlorothiazideDutoprol
Prescription onlyPrescription only
Available as
hydrochlorothiazideDutoprol
  • Pill
  • Pill
Used for
hydrochlorothiazideDutoprol
Risk factors for serious side effects
hydrochlorothiazideDutoprol
  • Current electrolyte imbalance
  • Lower kidney function
  • Dehydration
  • History of sulfa allergies
  • History of gout
Detailed Microzide (hydrochlorothiazide ) risks & warnings »
  • Sudden discontinuation of medicine
  • History of asthma
  • History of diabetes
  • Age 65 years or older
  • Using other medicine(s) that slows the heart
Detailed Dutoprol (metoprolol succinate / hydrochlorothiazide) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
hydrochlorothiazideDutoprol
  • Requires routine blood tests to check kidney function.
  • Check your blood pressure and kidney function 1 week after starting the medicine, then routinely after that.
Upsides and benefits
hydrochlorothiazideDutoprol
  • Does a good job getting rid of extra fluids in your body by making you urinate more.
  • A first-choice blood pressure treatment. Works especially well for people of African descent.
  • Lowers the risk of heart attack and stroke.
  • Good option if you have high blood pressure and heart failure.
  • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
  • Can be good for patients with osteoporosis since it raises the body's level of calcium.
  • Lowers the risk of heart attack and stroke.
  • Combines the benefits of two blood pressure-lowering medicines in a single pill.
  • Helpful in getting rid of extra fluids in your body.
Downsides and risks
hydrochlorothiazideDutoprol
  • Makes you urinate more often.
  • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
  • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
  • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
  • Not the first choice to lower blood pressure.
  • Brand only, can be more expensive.
  • Can make you urinate more often and feel out of breath during physical activities, which may not go away.
  • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
  • Forgetting to take the medicine or stopping it suddenly can cause a heart attack.
Tips from our pharmacists for people taking the medication
hydrochlorothiazideDutoprol
  • Microzide (hydrochlorothiazide (HCTZ)) starts working in about 2 hours.
  • It makes you urinate more often, so don't take it at bedtime.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Tell your doctor about any tiredness or muscle weakness that doesn't go away.
  • Requires routine blood tests to check kidney function.
  • Makes you urinate more often, so don't take it too close to bedtime.
  • Can make you feel dizzy or short of breath the first few days, but this should improve as your body gets used to the medicine.
  • Check your blood pressure and kidney function 1 week after starting the medicine, then routinely after that.
  • Tell your doctor about any cold-like symptoms, dizziness, headache, fatigue, or muscle weakness that doesn't go away.
  • Don't stop taking this medicine suddenly since it can trigger heart problems.
Learn more
More about hydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it
More about DutoprolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Dutoprol (metoprolol succinate / hydrochlorothiazide)?
Worth itNot sureNot worth it