Compare hydrochlorothiazide vs. Hyzaar

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Removes water from the body, which lowers blood pressure.

Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.

3.3/ 5 average rating with 139 reviewsforhydrochlorothiazide
Lowers blood pressure. Removes extra water from your body.

Hyzaar (Losartan / Hydrochlorothiazide) is a good combination blood pressure-lowering medicine to try if your blood pressure is very high.

Upsides
  • Does a good job getting rid of extra fluids in your body by making you urinate more.
  • A first-choice blood pressure treatment. Works especially well for people of African descent.
  • Lowers the risk of heart attack and stroke.
  • Good option if you have high blood pressure and heart failure.
  • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
  • Can be good for patients with osteoporosis since it raises the body's level of calcium.
  • Lowers the risk of heart attack and stroke.
  • A first-choice treatment for severe high blood pressure, combining the benefits of two blood pressure-lowering medicines with a single pill.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Helpful in getting rid of extra fluids if you have issues with fluid balance (like in congestive heart failure).
  • Most people have few side effects.
Downsides
  • Makes you urinate more often.
  • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
  • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
  • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
  • Will make you urinate more often.
  • Requires a yearly blood test to see how the medicine is affecting your electrolytes and kidneys.
  • Not safe to use if you're pregnant.
  • Needs dose adjustment if you have liver problems.
  • Your skin will be more sensitive to the sun while taking this.
  • Won't work as well if you have severe kidney problems.
  • Shouldn't take if you have a sulfa allergy.
Used for
Dosage forms
  • Pill
  • Pill
Price
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Reviews
139 reviews so far
47%
saidit'sworth it
31%
saiditworked well
16%
saidit'sa big hassle

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Side effects
The Microzide (hydrochlorothiazide (HCTZ)) FDA package insert doesn’t have numbers about how common side effects are.
4possible side effects
  • Dizziness
    6%
  • Upper respiratory infection
    6%
  • Cough   
    3%
  • Back pain
    2%
See more detailed side effects
Risks and risk factors
  • Dehydration and electrolyte imbalance
    • Current electrolyte imbalance
    • Lower kidney function
    • Dehydration
  • Severe allergic reactions
    • History of sulfa allergies
  • Gout
    • History of gout
    • Current kidney problems
  • Vision problems
    • History of sulfa or penicillin allergies
  • Higher blood sugars
    • Diabetes
See more detailed risks and warnings
  • Harm to fetus
    • Women of childbearing age
  • Worsening kidney problems
    • History of kidney problems
  • Unusual tongue swelling
    • African descent
  • Heart or muscle problems due to potassium imbalance
    • Current kidney problems
    • Medicine that affects potassium
    • Use of salt substitute
  • Severe allergic reactions
    • History of sulfa allergies
  • Gout
    • History of gout
    • Current kidney problems
See more detailed risks and warnings