Compare Hydrochlorothiazide vs. Hyzaar

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Microzide
(Hydrochlorothiazide )

Hyzaar
(Losartan / Hydrochlorothiazide)

Lowers blood pressure. Removes extra water from your body. Microzide (Hydrochlorothiazide (Hctz)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.Lowers blood pressure. Removes extra water from your body. Hyzaar (Losartan / Hydrochlorothiazide) is a good combination blood pressure-lowering medicine to try if your blood pressure is very high.
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Reviews & ratings
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4.467153284671533Hydrochlorothiazide
Reviews for Microzide (Hydrochlorothiazide (Hctz))
47%
of people say Microzide (Hydrochlorothiazide (Hctz)) is worth it
31%
say it works well
15%
say it's a big hassle

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Side effects
HydrochlorothiazideHyzaar

The Hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about Hydrochlorothiazide side effects »
  • Dizziness 3%
  • Back pain 1%
  • Cough 1%
  • Upper respiratory infection 1%
More Hyzaar side effects »
How it works
HydrochlorothiazideHyzaar
Microzide (Hydrochlorothiazide (Hctz)) is a thiazide diuretic (water pill). It works in the kidneys to make you urinate more, which removes extra water and certain electrolytes. This lowers blood pressure and swelling.Hyzaar (Losartan / Hydrochlorothiazide) is a combination medicine that lowers your blood pressure. Hydrochlorothiazide is a diuretic that removes extra water from your body. Losartan is an angiotensin receptor blocker (ARB) that relaxes your blood vessels to lower you blood pressure and allow more blood and oxygen to get to your heart and other organs.
Type of medication
HydrochlorothiazideHyzaar
Antihypertensive
Diuretic
Prescription only
Antihypertensive
Angiotensin receptor blocker
Diuretic
Prescription only
Available as
HydrochlorothiazideHyzaar
  • Pill
  • Pill
Used for (click to learn more)
HydrochlorothiazideHyzaar
Risk factors for serious side effects
HydrochlorothiazideHyzaar
  • Current electrolyte imbalance
  • History of sulfa allergies
  • History of gout
  • Current kidney problems
    Detailed Microzide (Hydrochlorothiazide (Hctz)) risks & warnings »
    • Women of childbearing age
    • History of kidney problems
    • African descent
    • Current kidney problems
    • Medicine that affects potassium
    • Use of salt substitute
    • History of sulfa allergies
    • History of gout
    • Current kidney problems
    Detailed Hyzaar (Losartan / Hydrochlorothiazide) risks & warnings »
    Pregnancy category
    HydrochlorothiazideHyzaar
    BFDA pregnancy category (Probably safe)

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    See the FDA package insert
    DFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.
    Food
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    • Doesn't work well in people with severe kidney problems.
    • Requires routine blood tests to check kidney function.
    • Requires a yearly blood test to see how the medicine is affecting your electrolytes and kidneys.
    • Won't work as well if you have severe kidney problems.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Get your blood pressure, potassium, and kidney function checked 1 week after starting the medicine, then routinely after.
    • Requires routine blood tests to check kidney function.
    • Hyzaar (Losartan / Hydrochlorothiazide) has a risk of making your kidneys not work as well. It is important to get blood work done to check your kidney function before starting Hyzaar (Losartan / Hydrochlorothiazide) and at least annually after.
    • Hyzaar (Losartan / Hydrochlorothiazide) can affect the potassium level in your body. Too much potassium can cause heart problems and too little potassium can cause muscle problems. Baseline and routine lab tests are needed to measure your potassium and kidney function.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    HydrochlorothiazideHyzaar
    • Works well to get rid of extra fluids in your body through urination.
    • A first-choice blood pressure treatment for many people. Works especially well for African Americans.
    • Good option if you have both high blood pressure and heart failure.
    • Raises calcium levels in the body, so it can be good for people with osteoporosis to slow down bone loss and even help with new bone formation.
    • Most people have very few side effects.
    • Lowers the risk of heart attack and stroke.
    • A first-choice treatment for severe high blood pressure, combining the benefits of two blood pressure-lowering medicines with a single pill.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Helpful in getting rid of extra fluids if you have issues with fluid balance (like in congestive heart failure).
    • Most people have few side effects.
    • Lowers the risk of heart attack and stroke.
    Downsides and risks
    HydrochlorothiazideHyzaar
    • Makes you urinate more often.
    • Doesn't work well in people with severe kidney problems.
    • Will make you urinate more often.
    • Requires a yearly blood test to see how the medicine is affecting your electrolytes and kidneys.
    • Not safe to use if you're pregnant.
    • Needs dose adjustment if you have liver problems.
    • Your skin will be more sensitive to the sun while taking this.
    • Won't work as well if you have severe kidney problems.
    • Shouldn't take if you have a sulfa allergy.
    Tips from our pharmacists for people taking the medication
    HydrochlorothiazideHyzaar
    • Starts working in about 2 hours.
    • Makes you urinate more often, so avoid taking it at bedtime.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Tell your doctor about any dizziness, fatigue, or muscle weakness that doesn't go away.
    • Can cause dizziness in the first few days.
    • Requires routine blood tests to check kidney function.
    • Get your blood pressure, potassium, and kidney function checked 1 week after starting the medicine, then routinely after.
    • Tell your doctor about any dizziness or muscle weakness that doesn't go away.
    • Get immediate medical help if you notice any swelling, especially around your head and neck.
    • Don't take it if you're pregnant.
    • Can cause dizziness in the first few days.
    • Requires routine blood tests to check kidney function.
    Learn more
    More about HydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
    More about HyzaarSide effectsReviews & ratingsAlternativesFDA package insert