Compare Hydrochlorothiazide vs. Hyzaar

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Microzide
(Hydrochlorothiazide )

Hyzaar
(Losartan / Hydrochlorothiazide)

Lowers blood pressure. Removes extra water from your body. Microzide (Hydrochlorothiazide (Hctz)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.Lowers blood pressure. Removes extra water from your body. Hyzaar (Losartan / Hydrochlorothiazide) is a good combination blood pressure-lowering medicine to try if your blood pressure is very high.
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Reviews & ratings
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4.48Hydrochlorothiazide
Reviews for Microzide (Hydrochlorothiazide (Hctz))
47%
of people (All ages) say Microzide (Hydrochlorothiazide (Hctz)) is worth it
31%
say it works well
16%
say it's a big hassle
139 reviews
Have you used Microzide (Hydrochlorothiazide (Hctz))?
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Have you used Hyzaar (Losartan / Hydrochlorothiazide)?
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Side effects
HydrochlorothiazideHyzaar

The Hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about Hydrochlorothiazide side effects »
  • Dizziness 3%
  • Upper respiratory infection 1%
  • Cough 1%
  • Back pain 1%
More Hyzaar side effects »
How it works
HydrochlorothiazideHyzaar
Microzide (Hydrochlorothiazide (Hctz)) is a thiazide diuretic (water pill). It works in the kidneys to make you urinate more, which removes extra water and certain electrolytes. This lowers blood pressure and swelling.Hyzaar (Losartan / Hydrochlorothiazide) is a combination medicine that lowers your blood pressure. Hydrochlorothiazide is a diuretic that removes extra water from your body. Losartan is an angiotensin receptor blocker (ARB) that relaxes your blood vessels to lower you blood pressure and allow more blood and oxygen to get to your heart and other organs.
Type of medication
HydrochlorothiazideHyzaar
Prescription only
Prescription only
Available as
HydrochlorothiazideHyzaar
  • Pill
  • Pill
Used for
HydrochlorothiazideHyzaar
Risk factors for serious side effects
HydrochlorothiazideHyzaar
  • Current electrolyte imbalance
  • History of sulfa allergies
  • History of gout
  • Current kidney problems
    Detailed Microzide (Hydrochlorothiazide (Hctz)) risks & warnings »
    • Women of childbearing age
    • History of kidney problems
    • African descent
    • Current kidney problems
    • Medicine that affects potassium
    • Use of salt substitute
    • History of sulfa allergies
    • History of gout
    • Current kidney problems
    Detailed Hyzaar (Losartan / Hydrochlorothiazide) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Kidneys and liver
    HydrochlorothiazideHyzaar
    • Requires routine blood tests to check kidney function.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Requires a yearly blood test to see how the medicine is affecting your electrolytes and kidneys.
    • Needs dose adjustment if you have liver problems.
    • Get your blood pressure, potassium, and kidney function checked 1 week after starting the medicine, then routinely after.
    • Requires routine blood tests to check kidney function.
    • Hyzaar (Losartan / Hydrochlorothiazide) can affect the potassium level in your body. Too much potassium can cause heart problems and too little potassium can cause muscle problems. Baseline and routine lab tests are needed to measure your potassium and kidney function.
    Upsides and benefits
    HydrochlorothiazideHyzaar
    • Works well to get rid of extra fluids in your body through urination.
    • A first-choice blood pressure treatment for many people. Works especially well for African Americans.
    • Lowers the risk of heart attack and stroke.
    • Good option if you have both high blood pressure and heart failure.
    • Raises calcium levels in the body, so it can be good for people with osteoporosis to slow down bone loss and even help with new bone formation.
    • Most people have very few side effects.
    • Lowers the risk of heart attack and stroke.
    • A first-choice treatment for severe high blood pressure, combining the benefits of two blood pressure-lowering medicines with a single pill.
    • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
    • Helpful in getting rid of extra fluids if you have issues with fluid balance (like in congestive heart failure).
    • Most people have few side effects.
    Downsides and risks
    HydrochlorothiazideHyzaar
    • Makes you urinate more often.
    • Doesn't work well in people with severe kidney problems.
    • Will make you urinate more often.
    • Requires a yearly blood test to see how the medicine is affecting your electrolytes and kidneys.
    • Not safe to use if you're pregnant.
    • Needs dose adjustment if you have liver problems.
    • Your skin will be more sensitive to the sun while taking this.
    • Won't work as well if you have severe kidney problems.
    • Shouldn't take if you have a sulfa allergy.
    Tips from our pharmacists for people taking the medication
    HydrochlorothiazideHyzaar
    • Starts working in about 2 hours.
    • Makes you urinate more often, so avoid taking it at bedtime.
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Tell your doctor about any dizziness, fatigue, or muscle weakness that doesn't go away.
    • Requires routine blood tests to check kidney function.
    • Can cause dizziness in the first few days.
    • Get your blood pressure, potassium, and kidney function checked 1 week after starting the medicine, then routinely after.
    • Tell your doctor about any dizziness or muscle weakness that doesn't go away.
    • Get immediate medical help if you notice any swelling, especially around your head and neck.
    • Requires routine blood tests to check kidney function.
    • Don't take it if you're pregnant.
    Learn more
    More about HydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Microzide (Hydrochlorothiazide (Hctz))?
    Worth itNot sureNot worth it
    More about HyzaarSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Hyzaar (Losartan / Hydrochlorothiazide)?
    Worth itNot sureNot worth it