Compare hydrochlorothiazide vs. Lisinopril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Microzide (hydrochlorothiazide)

Prescription only

Zestril (lisinopril)

Prescription only
Removes water from the body, which lowers blood pressure.

Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.

4.5/ 7 average rating with 139 reviewsforhydrochlorothiazide
Lowers blood pressure.

Zestril (lisinopril) is a good blood pressure-lowering medicine that protects kidney function.

5.2/ 7 average rating with 687 reviewsforLisinopril
Upsides
  • Does a good job getting rid of extra fluids in your body by making you urinate more.
  • A first-choice blood pressure treatment. Works especially well for people of African descent.
  • Lowers the risk of heart attack and stroke.
  • Good option if you have high blood pressure and heart failure.
  • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
  • Can be good for patients with osteoporosis since it raises the body's level of calcium.
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • Very cheap drug, and comes available as a liquid for children over 6 years of age.
Downsides
  • Makes you urinate more often.
  • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
  • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
  • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
  • Up to 10% of people can get a dry cough while using this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Zestril (lisinopril) isn't safe to use if you're pregnant.
  • Doesn't work as well in people of African descent, and can cause a greater chance of face, tongue, or lip swelling.
Used for
Dosage forms
  • Pill
  • Pill
  • Liquid
Price
Lowest price near you
$4
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Lowest price near you
$4
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Reviews
139 
47%
think this treatment is worth it
31%
think this treatment works well
16%
think this treatment is a hassle

Have you used Microzide (hydrochlorothiazide (HCTZ))?

Leave a review
687 
61%
think this treatment is worth it
51%
think this treatment works well
14%
think this treatment is a hassle

Have you used Zestril (lisinopril)?

Leave a review
Side effects
The Microzide (hydrochlorothiazide (HCTZ)) FDA package insert doesn’t have numbers about how common side effects are.
1possible side effects
  • Low blood pressure
    5%
See more detailed side effects
Risks and warnings
  • Dehydration and electrolyte imbalance

    Current electrolyte imbalance

    ...and 2 more risk factors

  • Severe allergic reactions

    History of sulfa allergies

  • Gout

    History of gout

    ...and 1 more risk factors

  • Vision problems

    History of sulfa or penicillin allergies

  • Higher blood sugars

    Diabetes

See more detailed risks and warnings
  • Harm to fetus

    Women of childbearing age

  • Swelling of face and head

    African descent

  • High potassium

    Current kidney problems

    ...and 2 more risk factors

  • Worsening kidney problems

    History of kidney problems

  • Low blood pressure

    Taking with alcohol

    ...and 1 more risk factors

See more detailed risks and warnings