Compare Hydrochlorothiazide vs. Prazosin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Microzide
(Hydrochlorothiazide )

Minipress
(Prazosin)

Lowers blood pressure. Removes extra water from your body. Microzide (Hydrochlorothiazide (Hctz)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.Lowers blood pressure and makes it easier to urinate. Prazosin is used mostly to make urination easier for men with an enlarged prostate, but it can cause dizziness.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.48Hydrochlorothiazide
Reviews for Microzide (Hydrochlorothiazide (Hctz))
47%
of people (All ages) say Microzide (Hydrochlorothiazide (Hctz)) is worth it
31%
say it works well
16%
say it's a big hassle
139 reviews
Have you used Microzide (Hydrochlorothiazide (Hctz))?
Worth itNot sureNot worth it
Reviews for Minipress (Prazosin)
46%
-1% worse vs. Microzide (Hydrochlorothiazide (Hctz))
29%
-2% worse vs. Microzide (Hydrochlorothiazide (Hctz))
15%
+1% better vs. Microzide (Hydrochlorothiazide (Hctz))
Have you used Minipress (Prazosin)?
Worth itNot sureNot worth it
Side effects
HydrochlorothiazidePrazosin

The Hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about Hydrochlorothiazide side effects »
  • Dizziness 10%
  • Headache 8%
  • Drowsiness 8%
  • Lack of energy 7%
  • Weakness 7%
  • Heart pounding or racing sensation 5%
  • Nausea 5%
More Prazosin side effects »
How it works
HydrochlorothiazidePrazosin
Microzide (Hydrochlorothiazide (Hctz)) is a thiazide diuretic (water pill). It works in the kidneys to make you urinate more, which removes extra water and certain electrolytes. This lowers blood pressure and swelling.Prazosin is a selective alpha blocker. It lowers blood pressure by relaxing blood vessels. It also relaxes the urethra and prostate, which makes it easier to urinate.
Type of medication
HydrochlorothiazidePrazosin
Prescription only
Prescription only
Available as
HydrochlorothiazidePrazosin
  • Pill
  • Pill
Used for
HydrochlorothiazidePrazosin
Risk factors for serious side effects
HydrochlorothiazidePrazosin
  • Current electrolyte imbalance
  • History of sulfa allergies
  • History of gout
  • Current kidney problems
    Detailed Microzide (Hydrochlorothiazide (Hctz)) risks & warnings »
    • Age 65 years or older
    Detailed Minipress (Prazosin) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Food
    HydrochlorothiazidePrazosin
    No food related info.
    • Take with food or at bedtime to avoid side effects.
    Kidneys and liver
    HydrochlorothiazidePrazosin
    • Requires routine blood tests to check kidney function.
    No kidneys and liver related info.
    Sleep
    HydrochlorothiazidePrazosin
    No sleep related info.
    • Can cause drowsiness, headache, dizziness, and nausea.
    Upsides and benefits
    HydrochlorothiazidePrazosin
    • Works well to get rid of extra fluids in your body through urination.
    • A first-choice blood pressure treatment for many people. Works especially well for African Americans.
    • Lowers the risk of heart attack and stroke.
    • Good option if you have both high blood pressure and heart failure.
    • Raises calcium levels in the body, so it can be good for people with osteoporosis to slow down bone loss and even help with new bone formation.
    • Most people have very few side effects.
    • Can be added to other blood pressure-lowering medicines if you need additional blood pressure control.
    • Makes urination easier in men with an enlarged prostate.
    • Helps people with PTSD get better sleep with fewer, less-intense nightmares.
    Downsides and risks
    HydrochlorothiazidePrazosin
    • Makes you urinate more often.
    • Doesn't work well in people with severe kidney problems.
    • Not the best medicine to lower blood pressure by itself.
    • Likely to cause orthostatic hypotension. This means dizziness when you change positions (like standing up) because your blood pressure doesn't adjust quickly enough.
    • Not preferred for people 65 years or older.
    Tips from our pharmacists for people taking the medication
    HydrochlorothiazidePrazosin
    • Starts working in about 2 hours.
    • Makes you urinate more often, so avoid taking it at bedtime.
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Tell your doctor about any dizziness, fatigue, or muscle weakness that doesn't go away.
    • Requires routine blood tests to check kidney function.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Can cause drowsiness, headache, dizziness, and nausea.
    • Take with food or at bedtime to avoid side effects.
    • If side effects don't go away, talk to your doctor about alternatives.
    • Recheck your blood pressure 1 week after starting this medicine.
    Learn more
    More about HydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Microzide (Hydrochlorothiazide (Hctz))?
    Worth itNot sureNot worth it
    More about PrazosinSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Minipress (Prazosin)?
    Worth itNot sureNot worth it