Compare hydrochlorothiazide vs. Prazosin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Microzide
(hydrochlorothiazide )

Minipress
(prazosin)

Removes water from the body, which lowers blood pressure. Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.Lowers blood pressure and makes it easier to urinate. Prazosin is used mostly to make urination easier for men with an enlarged prostate, but it can cause dizziness.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.48hydrochlorothiazide
Reviews for hydrochlorothiazide
47%
of people (All ages) say hydrochlorothiazide is worth it
31%
say it works well
16%
say it's a big hassle
139 reviews
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it
Reviews for Prazosin
46%
+1% better vs. hydrochlorothiazide
29%
+2% better vs. hydrochlorothiazide
15%
-1% worse vs. hydrochlorothiazide
Have you used Minipress (prazosin)?
Worth itNot sureNot worth it
Side effects
hydrochlorothiazidePrazosin

The hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about hydrochlorothiazide side effects »
  • Dizziness 10%
  • Headache 8%
  • Drowsiness 8%
  • Lack of energy 7%
  • Weakness 7%
  • Palpitations 5%
  • Nausea 5%
More Prazosin side effects »
How it works
hydrochlorothiazidePrazosin
Microzide (hydrochlorothiazide (HCTZ)) is a thiazide diuretic (water pill) that makes you urinate more. It works in the kidneys to remove extra water and certain electrolytes, while lowering blood pressure and reducing swelling.Prazosin is a selective alpha blocker. It lowers blood pressure by relaxing blood vessels. It also relaxes the urethra and prostate, which makes it easier to urinate.
Type of medication
hydrochlorothiazidePrazosin
Prescription onlyPrescription only
Available as
hydrochlorothiazidePrazosin
  • Pill
  • Pill
Used for
hydrochlorothiazidePrazosin
Risk factors for serious side effects
hydrochlorothiazidePrazosin
  • Current electrolyte imbalance
  • Lower kidney function
  • Dehydration
  • History of sulfa allergies
  • History of gout
Detailed Microzide (hydrochlorothiazide ) risks & warnings »
  • Age 65 years or older
Detailed Minipress (prazosin) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
hydrochlorothiazidePrazosin
No food related info.
  • Take with food or at bedtime to avoid side effects.
Kidneys and liver
hydrochlorothiazidePrazosin
  • Requires routine blood tests to check kidney function.
No kidneys and liver related info.
Sleep
hydrochlorothiazidePrazosin
No sleep related info.
  • Can cause drowsiness, headache, dizziness, and nausea.
Upsides and benefits
hydrochlorothiazidePrazosin
  • Does a good job getting rid of extra fluids in your body by making you urinate more.
  • A first-choice blood pressure treatment. Works especially well for people of African descent.
  • Lowers the risk of heart attack and stroke.
  • Good option if you have high blood pressure and heart failure.
  • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
  • Can be good for patients with osteoporosis since it raises the body's level of calcium.
  • Can be added to other blood pressure-lowering medicines if you need additional blood pressure control.
  • Makes urination easier in men with an enlarged prostate.
  • Helps people with PTSD get better sleep with fewer, less-intense nightmares.
Downsides and risks
hydrochlorothiazidePrazosin
  • Makes you urinate more often.
  • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
  • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
  • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
  • Not the best medicine to lower blood pressure by itself.
  • Likely to cause orthostatic hypotension. This means dizziness when you change positions (like standing up) because your blood pressure doesn't adjust quickly enough.
  • Not preferred for people 65 years or older.
Tips from our pharmacists for people taking the medication
hydrochlorothiazidePrazosin
  • Microzide (hydrochlorothiazide (HCTZ)) starts working in about 2 hours.
  • It makes you urinate more often, so don't take it at bedtime.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Tell your doctor about any tiredness or muscle weakness that doesn't go away.
  • Requires routine blood tests to check kidney function.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Can cause drowsiness, headache, dizziness, and nausea.
  • Take with food or at bedtime to avoid side effects.
  • If side effects don't go away, talk to your doctor about alternatives.
  • Recheck your blood pressure 1 week after starting this medicine.
Learn more
More about hydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it
More about PrazosinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Minipress (prazosin)?
Worth itNot sureNot worth it