Compare Hydrochlorothiazide vs. Prazosin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Microzide
(Hydrochlorothiazide )

Minipress
(Prazosin)

Lowers blood pressure. Removes extra water from your body. Microzide (Hydrochlorothiazide (Hctz)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.Lowers blood pressure and makes it easier to urinate. Prazosin is used mostly to make urination easier for men with an enlarged prostate, but it can cause dizziness.
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Reviews & ratings
Button Group. All currently active
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4.467153284671533Hydrochlorothiazide
Reviews for Microzide (Hydrochlorothiazide (Hctz))
47%
of people say Microzide (Hydrochlorothiazide (Hctz)) is worth it
31%
say it works well
15%
say it's a big hassle
Reviews for Minipress (Prazosin)
43%
4% vs. Microzide (Hydrochlorothiazide (Hctz))
28%
3% vs. Microzide (Hydrochlorothiazide (Hctz))
15%
Same vs. Microzide (Hydrochlorothiazide (Hctz))
Side effects
HydrochlorothiazidePrazosin

The Hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about Hydrochlorothiazide side effects »

The Prazosin FDA package insert doesn’t have numbers about how common side effects are.

More about Prazosin side effects »
How it works
HydrochlorothiazidePrazosin
Microzide (Hydrochlorothiazide (Hctz)) is a thiazide diuretic (water pill). It works in the kidneys to make you urinate more, which removes extra water and certain electrolytes. This lowers blood pressure and swelling.Prazosin is a selective alpha blocker. It lowers blood pressure by relaxing blood vessels. It also relaxes the urethra and prostate, which makes it easier to urinate.
Type of medication
HydrochlorothiazidePrazosin
Antihypertensive
Diuretic
Prescription only
Antihypertensive
Alpha blocker
Prescription only
Available as
HydrochlorothiazidePrazosin
  • Pill
  • Pill
Used for (click to learn more)
HydrochlorothiazidePrazosin
Risk factors for serious side effects
HydrochlorothiazidePrazosin
  • Current electrolyte imbalance
  • History of sulfa allergies
  • History of gout
  • Current kidney problems
    Detailed Microzide (Hydrochlorothiazide (Hctz)) risks & warnings »
    • Age 65 years or older
    Detailed Minipress (Prazosin) risks & warnings »
    Pregnancy category
    HydrochlorothiazidePrazosin
    BFDA pregnancy category (Probably safe)

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.
    Food
    No specific food-related info.
    • Take with food or at bedtime to avoid side effects.
    Kidneys and liver
    • Doesn't work well in people with severe kidney problems.
    • Requires routine blood tests to check kidney function.
    No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.
    • Helps people with PTSD get better sleep with fewer, less-intense nightmares.
    • Can cause drowsiness, headache, dizziness, and nausea.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    HydrochlorothiazidePrazosin
    • Works well to get rid of extra fluids in your body through urination.
    • A first-choice blood pressure treatment for many people. Works especially well for African Americans.
    • Lowers the risk of heart attack and stroke.
    • Good option if you have both high blood pressure and heart failure.
    • Raises calcium levels in the body, so it can be good for people with osteoporosis to slow down bone loss and even help with new bone formation.
    • Most people have very few side effects.
    • Can be added to other blood pressure-lowering medicines if you need additional blood pressure control.
    • Makes urination easier in men with an enlarged prostate.
    • Helps people with PTSD get better sleep with fewer, less-intense nightmares.
    Downsides and risks
    HydrochlorothiazidePrazosin
    • Makes you urinate more often.
    • Doesn't work well in people with severe kidney problems.
    • Not the best medicine to lower blood pressure by itself.
    • Likely to cause orthostatic hypotension. This means dizziness when you change positions (like standing up) because your blood pressure doesn't adjust quickly enough.
    • Not preferred for people 65 years or older.
    Tips from our pharmacists for people taking the medication
    HydrochlorothiazidePrazosin
    • Starts working in about 2 hours.
    • Makes you urinate more often, so avoid taking it at bedtime.
    • Can cause dizziness in the first few days.
    • Tell your doctor about any dizziness, fatigue, or muscle weakness that doesn't go away.
    • Requires routine blood tests to check kidney function.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Can cause drowsiness, headache, dizziness, and nausea.
    • Take with food or at bedtime to avoid side effects.
    • If side effects don't go away, talk to your doctor about alternatives.
    • Recheck your blood pressure 1 week after starting this medicine.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    Learn more
    More about HydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
    More about PrazosinSide effectsReviews & ratingsAlternativesFDA package insert