Compare hydrochlorothiazide vs. Toprol XL

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Microzide
(hydrochlorothiazide )

Toprol XL
(metoprolol succinate)

Removes water from the body, which lowers blood pressure. Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.Lowers blood pressure and controls heart rate. Toprol XL (metoprolol succinate) is good for controlling chest pain, treating heart failure, and heart attack. It has the added benefit of being taken once a day.
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Best available price for 30 (12.5mg) capsules of hydrochlorothiazide
Coupons for Toprol XL
Best available price for 30 (25mg) tablets of toprol-xl
Reviews & ratings
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Filter group. All currently selected
4.48hydrochlorothiazide
Reviews for hydrochlorothiazide
47%
of people (All ages) say hydrochlorothiazide is worth it
31%
say it works well
16%
say it's a big hassle
139 reviews
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it
Reviews for Toprol XL
60%
-13% worse vs. hydrochlorothiazide
54%
-23% worse vs. hydrochlorothiazide
13%
-3% worse vs. hydrochlorothiazide
164 reviews
Have you used Toprol XL (metoprolol succinate)?
Worth itNot sureNot worth it
Side effects
hydrochlorothiazideToprol XL

The hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about hydrochlorothiazide side effects »
  • Tiredness 10%
  • Dizziness 10%
  • Low mood disorder 5%
  • Skin rash and itching 5%
  • Diarrhea 5%
  • Shortness of breath 3%
  • Slower heartbeat 3%
  • Dizziness/balance problems 1%
More Toprol XL side effects »
How it works
hydrochlorothiazideToprol XL
Microzide (hydrochlorothiazide (HCTZ)) is a thiazide diuretic (water pill) that makes you urinate more. It works in the kidneys to remove extra water and certain electrolytes, while lowering blood pressure and reducing swelling.Toprol XL (metoprolol succinate) is a beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.
Type of medication
hydrochlorothiazideToprol XL
Prescription onlyPrescription only
Available as
hydrochlorothiazideToprol XL
  • Pill
  • Extended release
Used for
hydrochlorothiazideToprol XL
Risk factors for serious side effects
hydrochlorothiazideToprol XL
  • Current electrolyte imbalance
  • Lower kidney function
  • Dehydration
  • History of sulfa allergies
  • History of gout
Detailed Microzide (hydrochlorothiazide ) risks & warnings »
  • Sudden discontinuation of medicine
  • Coronary artery disease
  • Diabetes
  • Hyperthyroidsim
  • Heart failure
Detailed Toprol XL (metoprolol succinate) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Kidneys and liver
hydrochlorothiazideToprol XL
  • Requires routine blood tests to check kidney function.
No kidneys and liver related info.
Upsides and benefits
hydrochlorothiazideToprol XL
  • Does a good job getting rid of extra fluids in your body by making you urinate more.
  • A first-choice blood pressure treatment. Works especially well for people of African descent.
  • Lowers the risk of heart attack and stroke.
  • Good option if you have high blood pressure and heart failure.
  • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
  • Can be good for patients with osteoporosis since it raises the body's level of calcium.
  • A first-choice treatment to prevent chest pain (angina). It makes attacks less frequent and helps you be more active without having chest pain.
  • Toprol XL (metoprolol succinate) is a first-choice treatment for heart failure since it may prevent long-term heart damage.
  • It's also a first-choice for heart attack treatment since it lowers the risk of death during and after a heart attack.
  • Toprol XL (metoprolol succinate) is the extended release version of metoprolol tartrate and only needs to be taken once a day.
  • It's available as a generic and is relatively cheap.
Downsides and risks
hydrochlorothiazideToprol XL
  • Makes you urinate more often.
  • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
  • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
  • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
  • Taking a beta blocker can make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some this may not go away.
  • It's not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease.
  • Toprol XL (metoprolol succinate) can hide symptoms of low blood sugar if you have diabetes.
  • You can't miss doses. Stopping Toprol XL (metoprolol succinate) suddenly can cause your blood pressure to go up quickly, which increases your risk of heart attack and stroke.
Tips from our pharmacists for people taking the medication
hydrochlorothiazideToprol XL
  • Microzide (hydrochlorothiazide (HCTZ)) starts working in about 2 hours.
  • It makes you urinate more often, so don't take it at bedtime.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Tell your doctor about any tiredness or muscle weakness that doesn't go away.
  • Requires routine blood tests to check kidney function.
  • Toprol XL (metoprolol succinate) cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine and let your doctor know if it hasn't improved.
  • It can make you feel tired or give you headaches.
  • Can hide symptoms of low blood sugar, so be careful taking this if you have diabetes.
  • Don't stop taking this medicine suddenly.
  • This is the extended-release version, but it also comes in an immediate-release form, metoprolol tartrate.
Learn more
More about hydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it
More about Toprol XLSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Toprol XL (metoprolol succinate)?
Worth itNot sureNot worth it