Compare hydrochlorothiazide vs. Toprol XL

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Microzide (hydrochlorothiazide)

Prescription only
Removes water from the body, which lowers blood pressure.

Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.

4.5/ 7 average rating with 139 reviewsforhydrochlorothiazide
Lowers blood pressure and controls heart rate.

Toprol XL (metoprolol succinate) is good for controlling chest pain, treating heart failure, and heart attack. It has the added benefit of being taken once a day.

5.2/ 7 average rating with 164 reviewsforToprol XL
Upsides
  • Does a good job getting rid of extra fluids in your body by making you urinate more.
  • A first-choice blood pressure treatment. Works especially well for people of African descent.
  • Lowers the risk of heart attack and stroke.
  • Good option if you have high blood pressure and heart failure.
  • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
  • Can be good for patients with osteoporosis since it raises the body's level of calcium.
  • A first-choice treatment to prevent chest pain (angina). It makes attacks less frequent and helps you be more active without having chest pain.
  • Toprol XL (metoprolol succinate) is a first-choice treatment for heart failure since it may prevent long-term heart damage.
  • It's also a first-choice for heart attack treatment since it lowers the risk of death during and after a heart attack.
  • Toprol XL (metoprolol succinate) is the extended release version of metoprolol tartrate and only needs to be taken once a day.
  • It's available as a generic and is relatively cheap.
Downsides
  • Makes you urinate more often.
  • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
  • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
  • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
  • Taking a beta blocker can make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some this may not go away.
  • It's not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease.
  • Toprol XL (metoprolol succinate) can hide symptoms of low blood sugar if you have diabetes.
  • You can't miss doses. Stopping Toprol XL (metoprolol succinate) suddenly can cause your blood pressure to go up quickly, which increases your risk of heart attack and stroke.
Used for
Dosage forms
  • Pill
  • Extended release
Price
Lowest price near you
$4
Find instant savings
Lowest price near you
$39.66
Find instant savings
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
Reviews
139 
47%
think this treatment is worth it
31%
think this treatment works well
16%
think this treatment is a hassle

Have you used Microzide (hydrochlorothiazide (HCTZ))?

Leave a review
164 
60%
think this treatment is worth it
54%
think this treatment works well
13%
think this treatment is a hassle

Have you used Toprol XL (metoprolol succinate)?

Leave a review
Side effects
The Microzide (hydrochlorothiazide (HCTZ)) FDA package insert doesn’t have numbers about how common side effects are.
2possible side effects
  • Dizziness/balance problems
    2%
  • Slower heartbeat
    2%
See more detailed side effects
Risks and warnings
  • Dehydration and electrolyte imbalance

    Current electrolyte imbalance

    ...and 2 more risk factors

  • Severe allergic reactions

    History of sulfa allergies

  • Gout

    History of gout

    ...and 1 more risk factors

  • Vision problems

    History of sulfa or penicillin allergies

  • Higher blood sugars

    Diabetes

See more detailed risks and warnings
  • Heart problems

    Sudden discontinuation of medicine

    ...and 1 more risk factors

  • Masked symptoms of low blood sugar

    Diabetes

  • Masked symptoms of overactive thyroid

    Hyperthyroidsim

  • Increased symptoms of heart failure

    Heart failure

  • Increased risks during surgery

    Major surgery requiring anesthesia

  • Trouble breathing (bronchospastic disease)

    History of asthma

    ...and 1 more risk factors

See more detailed risks and warnings