Compare Hydrochlorothiazide vs. Toprol XL

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Microzide
(Hydrochlorothiazide )

Toprol Xl
(Metoprolol Succinate)

Lowers blood pressure. Removes extra water from your body. Microzide (Hydrochlorothiazide (Hctz)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.Lowers blood pressure and controls heart rate. Toprol Xl (Metoprolol Succinate) is good for controlling chest pain and treating heart failure and heart attack. You can't miss doses.
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Reviews & ratings
Button Group. All currently active
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4.467153284671533Hydrochlorothiazide
Reviews for Microzide (Hydrochlorothiazide (Hctz))
47%
of people say Microzide (Hydrochlorothiazide (Hctz)) is worth it
31%
say it works well
15%
say it's a big hassle
Reviews for Toprol Xl (Metoprolol Succinate)
60%
+13% vs. Microzide (Hydrochlorothiazide (Hctz))
55%
+24% vs. Microzide (Hydrochlorothiazide (Hctz))
13%
+2% vs. Microzide (Hydrochlorothiazide (Hctz))
Side effects
HydrochlorothiazideToprol XL

The Hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about Hydrochlorothiazide side effects »
  • Abnormally slow heartbeat 9%
  • Low blood pressure 4%
  • Heart block 3%
More Toprol XL side effects »
How it works
HydrochlorothiazideToprol XL
Microzide (Hydrochlorothiazide (Hctz)) is a thiazide diuretic (water pill). It works in the kidneys to make you urinate more, which removes extra water and certain electrolytes. This lowers blood pressure and swelling.Toprol Xl (Metoprolol Succinate) is a beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.
Type of medication
HydrochlorothiazideToprol XL
Antihypertensive
Diuretic
Prescription only
Antihypertensive
Beta blocker
Prescription only
Available as
HydrochlorothiazideToprol XL
  • Pill
  • Pill
  • Extended release
Used for (click to learn more)
HydrochlorothiazideToprol XL
Risk factors for serious side effects
HydrochlorothiazideToprol XL
  • Current electrolyte imbalance
  • History of sulfa allergies
  • History of gout
  • Current kidney problems
    Detailed Microzide (Hydrochlorothiazide (Hctz)) risks & warnings »
    • Diabetes
      • Coronary artery disease
      • Heart failure
      • Major surgery requiring anesthesia
      • History of asthma
      Detailed Toprol Xl (Metoprolol Succinate) risks & warnings »
      Pregnancy category
      HydrochlorothiazideToprol XL
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      • Doesn't work well in people with severe kidney problems.
      • Requires routine blood tests to check kidney function.
      No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      HydrochlorothiazideToprol XL
      • Works well to get rid of extra fluids in your body through urination.
      • A first-choice blood pressure treatment for many people. Works especially well for African Americans.
      • Lowers the risk of heart attack and stroke.
      • Good option if you have both high blood pressure and heart failure.
      • Raises calcium levels in the body, so it can be good for people with osteoporosis to slow down bone loss and even help with new bone formation.
      • Most people have very few side effects.
      • A first-choice treatment to prevent chest pain (angina). Makes pain attacks less frequent and makes it easier to be active without having chest pain.
      • A first-choice treatment for heart failure. May prevent long-term heart damage.
      • A first-choice treatment for heart attack. Lowers the risk of death during and after a heart attack.
      • Toprol XL is the extended release version of Lopressor.
      Downsides and risks
      HydrochlorothiazideToprol XL
      • Makes you urinate more often.
      • Doesn't work well in people with severe kidney problems.
      • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
      • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease.
      • Can hide symptoms of low blood sugar if you're diabetic.
      • You can't miss doses. Stopping Toprol XL suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
      Tips from our pharmacists for people taking the medication
      HydrochlorothiazideToprol XL
      • Starts working in about 2 hours.
      • Makes you urinate more often, so avoid taking it at bedtime.
      • Tell your doctor about any dizziness, fatigue, or muscle weakness that doesn't go away.
      • Requires routine blood tests to check kidney function.
      • Can cause dizziness in the first few days.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      • Can cause fatigue and headache.
      • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
      • Don't stop taking this medicine suddenly.
      • Extended release version. Also comes in immediate release called Lopressor (metoprolol tartrate).
      • Can cause dizziness in the first few days.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      Learn more
      More about HydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
      More about Toprol XLSide effectsReviews & ratingsAlternativesFDA package insert