Compare hydrochlorothiazide vs. Ziac

Head-to-head comparisons of medication uses, side effects, ratings, and more.

(hydrochlorothiazide )

(bisoprolol / hydrochlorothiazide)

Removes water from the body, which lowers blood pressure. Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.Coming soon.
Reviews & ratings
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Reviews for hydrochlorothiazide
of people (All ages) say hydrochlorothiazide is worth it
say it works well
say it's a big hassle
139 reviews
Have you used Microzide (hydrochlorothiazide )?
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Have you used Ziac (bisoprolol / hydrochlorothiazide)?
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Side effects

The hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about hydrochlorothiazide side effects »

We haven’t found good data for Ziac side effects.

FDA side effect reports for Ziac »
How it works
Microzide (hydrochlorothiazide (HCTZ)) is a thiazide diuretic (water pill) that makes you urinate more. It works in the kidneys to remove extra water and certain electrolytes, while lowering blood pressure and reducing swelling.Coming soon.
Type of medication
Prescription only
Available as
  • Pill
  • Pill
Used for
  • Hypertension
Risk factors for serious side effects
  • Current electrolyte imbalance
  • Lower kidney function
  • Dehydration
  • History of sulfa allergies
  • History of gout
Detailed Microzide (hydrochlorothiazide ) risks & warnings »
    Coming soon.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Kidneys and liver
    • Requires routine blood tests to check kidney function.
    No kidneys and liver related info.
    Upsides and benefits
    • Does a good job getting rid of extra fluids in your body by making you urinate more.
    • A first-choice blood pressure treatment. Works especially well for people of African descent.
    • Lowers the risk of heart attack and stroke.
    • Good option if you have high blood pressure and heart failure.
    • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
    • Can be good for patients with osteoporosis since it raises the body's level of calcium.
    Coming soon
    Downsides and risks
    • Makes you urinate more often.
    • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
    • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
    • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
    Coming soon
    Tips from our pharmacists for people taking the medication
    • Microzide (hydrochlorothiazide (HCTZ)) starts working in about 2 hours.
    • It makes you urinate more often, so don't take it at bedtime.
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Tell your doctor about any tiredness or muscle weakness that doesn't go away.
    • Requires routine blood tests to check kidney function.
    Coming soon
    Learn more
    More about hydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Microzide (hydrochlorothiazide )?
    Worth itNot sureNot worth it
    More about ZiacSide effectsReviews & ratingsFDA package insert
    Have you used Ziac (bisoprolol / hydrochlorothiazide)?
    Worth itNot sureNot worth it