Compare Hydrochlorothiazide vs. Ziac

Head-to-head comparisons of medication uses, side effects, ratings, and more.

(Hydrochlorothiazide )

(Bisoprolol / Hydrochlorothiazide)

Lowers blood pressure. Removes extra water from your body. Microzide (Hydrochlorothiazide (Hctz)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.Coming soon.
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Reviews & ratings
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Reviews for Microzide (Hydrochlorothiazide (Hctz))
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Side effects

The Hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about Hydrochlorothiazide side effects »

We haven’t found good data for Ziac side effects.

FDA side effect reports for Ziac »
How it works
Microzide (Hydrochlorothiazide (Hctz)) is a thiazide diuretic (water pill). It works in the kidneys to make you urinate more, which removes extra water and certain electrolytes. This lowers blood pressure and swelling.Coming soon.
Type of medication
Prescription only
Coming soon.
Available as
  • Pill
  • Pill
Used for (click to learn more)
  • Hypertension
Risk factors for serious side effects
  • Current electrolyte imbalance
  • History of sulfa allergies
  • History of gout
  • Current kidney problems
    Detailed Microzide (Hydrochlorothiazide (Hctz)) risks & warnings »
    Coming soon.
    Pregnancy category
    No specific alcohol-related info.No specific alcohol-related info.
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    • Doesn't work well in people with severe kidney problems.
    • Requires routine blood tests to check kidney function.
    No specific kidneys and liver-related info.
    No specific sex-related info.No specific sex-related info.
    No specific sleep-related info.No specific sleep-related info.
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    • Works well to get rid of extra fluids in your body through urination.
    • A first-choice blood pressure treatment for many people. Works especially well for African Americans.
    • Lowers the risk of heart attack and stroke.
    • Good option if you have both high blood pressure and heart failure.
    • Raises calcium levels in the body, so it can be good for people with osteoporosis to slow down bone loss and even help with new bone formation.
    • Most people have very few side effects.
    Coming soon.
    Downsides and risks
    • Makes you urinate more often.
    • Doesn't work well in people with severe kidney problems.
    Coming soon.
    Tips from our pharmacists for people taking the medication
    • Starts working in about 2 hours.
    • Makes you urinate more often, so avoid taking it at bedtime.
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Tell your doctor about any dizziness, fatigue, or muscle weakness that doesn't go away.
    • Requires routine blood tests to check kidney function.
    Coming soon.
    Learn more
    More about HydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
    More about ZiacSide effectsReviews & ratingsFDA package insert