Compare Hydrocortisone vs. Medrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Anusol Hc (Hydrocortisone)

Treats itchy or irritated skin.

Anusol Hc (Hydrocortisone) is a good topical steroid to try for treating minor rashes or skin irritation.

Calms down your immune system.

Medrol (methylprednisolone) is very effective for controlling allergic reactions and many types of inflammatory conditions, but it is associated with serious and potentially life-threatening side effects if you have to take it for a long time.

5.1/ 7 average rating with 66 reviewsforMedrol
  • Relieves itchy and irritated skin.
  • Doesn't cause the same types of side effects that oral forms of steroids do.
  • It's available over the counter in the drugstore.
  • Most people have very few side effects.
  • Medrol (methylprednisolone) is effective for treating a variety of conditions involving the immune system.
  • Can help improve energy and stimulate your appetite.
  • Works quickly to provide relief for swelling, rash, asthma attacks, and pain.
  • Medrol (methylprednisolone) is available in a generic form.
  • Available as blister packs that organize tablets into specific days and times for easier administration.
  • It's not a strong steroid, so it doesn't work for everyone.
  • When used longer than a week, it can cause skin-thinning and make it harder for broken skin to heal.
  • Medrol (methylprednisolone) can cause unwanted side effects such as mood changes, trouble sleeping, and increase in blood pressure as well as blood sugar at higher doses.
  • Long-term use can cause problems to your skin, bones, eyes, and place you at a higher risk for infections.
  • If Medrol (methylprednisolone) is used for more than 2 weeks, you will need to work with a doctor to get off of the medicine by gradually decreasing the dose.
  • Medrol (methylprednisolone) can cause harm to an unborn baby, so it might not be a good option for pregnant women.
  • Might cause abnormal growth and development when used in children.
Used for
  • Skin inflammation
  • Itching
Dosage forms
  • Cream, gel, or ointment
  • Lotion
  • Topical solution
  • Pill
  • Injection
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Side effects
The Anusol Hc (Hydrocortisone) FDA package insert doesn’t have numbers about how common side effects are.
The Medrol (methylprednisolone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Increased risk for infections

    Long-term treatment

    ...and 3 more risk factors

  • Kaposi's sarcoma

    Long-term treatment

  • Bone effects

    Dose of Anusol Hc (Hydrocortisone)

    ...and 1 more risk factors

See more detailed risks and warnings
  • Weakened immune system response to stress

    Taking high doses of Medrol (methylprednisolone) for a long period of time

    ...and 2 more risk factors

  • Increased risk for infections

    Taking other medicines that weaken the immune system

    ...and 4 more risk factors

  • Changes in heart and kidney function

    Those who had a recent heart attack

    ...and 1 more risk factors

  • Eye problems

    Those with cataracts and/or glaucoma

    ...and 1 more risk factors

  • Harm to fetus (unborn baby)

    Pregnant women

    ...and 1 more risk factors

See more detailed risks and warnings