Compare Hydrocortisone vs. Prednisolone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats itchy or irritated skin.

Anusol Hc (Hydrocortisone) is a good topical steroid to try for treating minor rashes or skin irritation.

Treats eye redness and swelling.

Pred Forte (Prednisolone) is strong medicine for eye redness and swelling without exposing the rest of your body to the steroid medicine.

Upsides
  • Relieves itchy and irritated skin.
  • Doesn't cause the same types of side effects that oral forms of steroids do.
  • It's available over the counter in the drugstore.
  • Most people have very few side effects.
  • Decreases swelling and redness in your eyes.
  • Doesn't cause the same types of side effects that oral forms of steroids do.
Downsides
  • It's not a strong steroid, so it doesn't work for everyone.
  • When used longer than a week, it can cause skin-thinning and make it harder for broken skin to heal.
  • Available only as a prescription medication.
  • You need good hand-eye coordination to get the eye drops into your eyes.
  • Can cause or worsen certain eye conditions.
Used for
  • Skin inflammation
  • Itching
Dosage forms
  • Cream, gel, or ointment
  • Lotion
  • Topical solution
  • Eye drops
Price
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Reviews
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Side effects
The Anusol Hc (Hydrocortisone) FDA package insert doesn’t have numbers about how common side effects are.
The Pred Forte (Prednisolone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Increased risk for infections
    • Long-term treatment
    • Not vaccinated against viral diseases
    • Contact with people who have viral illness
    • History of bacterial or viral conditions
  • Kaposi's sarcoma
    • Long-term treatment
  • Bone effects
    • Dose of Anusol Hc (Hydrocortisone)
    • Duration of treatment
See more detailed risks and warnings
  • Cataracts
    • Long-term use
  • Cornea hole
    • Long-term use
  • Glaucoma
    • Long-term use
    • History of glaucoma
  • Infections in your eyes
    • Long-term use
See more detailed risks and warnings