Compare ibuprofen vs. Acetaminophen With Codeine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Advil
(ibuprofen)

Tylenol #3
(acetaminophen / codeine)

Relieves pain, fever, and swelling. Advil (ibuprofen) works well for treating fever, inflammation, and a variety of mild to moderate pain conditions, but it doesn't last as long as other NSAIDs.Treats mild to moderate pain. Tylenol #3 (Acetaminophen / Codeine) is a good option to treat pain and cough as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.49ibuprofen
Reviews for ibuprofen
88%
of people (All ages) say ibuprofen is worth it
52%
say it works well
4%
say it's a big hassle
892 reviews
Have you used Advil (ibuprofen)?
Worth itNot sureNot worth it
Reviews for Acetaminophen With Codeine
69%
+19% better vs. ibuprofen
41%
+11% better vs. ibuprofen
9%
+5% better vs. ibuprofen
581 reviews
Have you used Tylenol #3 (acetaminophen / codeine)?
Worth itNot sureNot worth it
Side effects
ibuprofenAcetaminophen With Codeine

The ibuprofen FDA package insert doesn’t have numbers about how common side effects are.

More about ibuprofen side effects »

The Acetaminophen With Codeine FDA package insert doesn’t have numbers about how common side effects are.

More about Acetaminophen With Codeine side effects »
How it works
ibuprofenAcetaminophen With Codeine
Advil (ibuprofen) is a non-steroidal anti-inflammatory drug (NSAID). It stops the inflammation process in your body, which relieves pain, swelling, and fever.Tylenol #3 (Acetaminophen / Codeine) is a combination pain medicine. Codeine is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.
Type of medication
ibuprofenAcetaminophen With Codeine
Over-the-counterPrescription only
Available as
ibuprofenAcetaminophen With Codeine
  • Pill
  • Chewable tablet
  • Suspension
  • Pill
  • Liquid
Used for
ibuprofenAcetaminophen With Codeine
Risk factors for serious side effects
ibuprofenAcetaminophen With Codeine
  • History of heart problems
  • Taking Advil (ibuprofen) for a long period of time
  • History of stomach bleeding
  • Age 60 or older
  • Taking aspirin, other NSAIDs, or blood thinners
Detailed Advil (ibuprofen) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Alcohol
    ibuprofenAcetaminophen With Codeine
    No alcohol related info.
    • Avoid alcohol.
    Food
    ibuprofenAcetaminophen With Codeine
    • Take it with food or milk to prevent stomach upset.
    • It needs to be taken with food or millk to avoid getting an upset stomach.
    • Take it with food to lower the chance of an upset stomach.
    Kidneys and liver
    ibuprofenAcetaminophen With Codeine
    • Advil (ibuprofen) can damage your kidneys. Taking the lowest dose for the shortest amount of time lowers your risk. Talk to your doctor if this worries you, or if you already have kidney damage before you start taking Advil (ibuprofen).
    • Don't take more than instructed to prevent liver damage.
    Pain
    ibuprofenAcetaminophen With Codeine
    • Do not take for more than 10 days for pain relief or more than 3 days for fever. Talk to your doctor if your symptoms do not go away.
    • Good for relieving pain due to common conditions like menstrual cramps, toothaches, backaches, and sports-related injuries.
    • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
    • Works best if you take it as soon as you start feeling pain.
    • Pain relief lasts 4-6 hours.
    • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Good for as-needed pain and control.
    Sleep
    ibuprofenAcetaminophen With Codeine
    No sleep related info.
    • Can help you fall asleep easier.
    • Dizziness and drowsiness is common, but your body may adjust.
    Upsides and benefits
    ibuprofenAcetaminophen With Codeine
    • Advil (ibuprofen) is effective for treating fever, pain, and inflammation.
    • Good for relieving pain due to common conditions like menstrual cramps, toothaches, backaches, and sports-related injuries.
    • Advil (ibuprofen) is generally safe to use, cheap, and available over-the-counter.
    • Advil (ibuprofen) causes less stomach problems than its alternatives.
    • It comes in different flavored liquid forms that makes it easy for children to take.
    • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Provides quick relieve for mild to moderate pain to improve quality of life.
    • Good for as-needed pain and control.
    • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
    • Lower rates of misuse compared to pure opioid medicines.
    • Can help you fall asleep easier.
    Downsides and risks
    ibuprofenAcetaminophen With Codeine
    • Advil (ibuprofen) doesn't last as long as other NSAIDs, so you need to take it a few times a day to get relief of your symptoms.
    • It needs to be taken with food or millk to avoid getting an upset stomach.
    • Advil (ibuprofen) is not as safe as other alternatives for pregnant women and people who are age 60 or older.
    • It can cause serious complications like stomach bleeding and kidney problems if taken for a long period of time.
    • Like all NSAIDs, Advil (ibuprofen) can raise your risk of getting blood clots, a heart attack, or stroke.
    • Dizziness and drowsiness is common, but your body may adjust.
    • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Acetaminophen with codeine if you need.
    • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
    • The non-opioid part of Acetaminophen with codeine, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
    • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
    • Avoid alcohol.
    Tips from our pharmacists for people taking the medication
    ibuprofenAcetaminophen With Codeine
    • Starts working in about 30 to 60 minutes.
    • Take it with food or milk to prevent stomach upset.
    • Do not take for more than 10 days for pain relief or more than 3 days for fever. Talk to your doctor if your symptoms do not go away.
    • If you normally take a daily aspirin, make sure to take Advil (ibuprofen) at least 30 minutes after taking aspirin or more than 8 hours before taking aspirin. This will help make sure the aspirin still works in your body.
    • Advil (ibuprofen) increases the risk of stomach bleeding so tell your doctor right away if you experience any bleeding.
    • If you are allergic to aspirin, there is a chance you may be allergic to Advil (ibuprofen) as well.
    • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
    • Starts working in 30 minutes.
    • Works best if you take it as soon as you start feeling pain.
    • Pain relief lasts 4-6 hours.
    • Can make you dizzy or drowsy.
    • Avoid activities need you to be fully alert until you know how it affects you.
    • Take it with food to lower the chance of an upset stomach.
    • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
    • Don't take more than instructed to prevent liver damage.
    • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
    • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
    Learn more
    More about ibuprofenSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Advil (ibuprofen)?
    Worth itNot sureNot worth it
    More about Acetaminophen With CodeineSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Tylenol #3 (acetaminophen / codeine)?
    Worth itNot sureNot worth it