Compare Ibuprofen vs. Acetaminophen With Codeine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Advil
(Ibuprofen)

Tylenol #3
(Acetaminophen / Codeine)

Relieves pain, fever, and inflammation. Advil (Ibuprofen) works well for mild to moderate pain and inflammation, but it doesn't last as long as other NSAIDs.Treats mild to moderate pain. Tylenol #3 (Acetaminophen / Codeine) is a good option to treat pain and cough as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.49Ibuprofen
Reviews for Advil (Ibuprofen)
88%
of people (All ages) say Advil (Ibuprofen) is worth it
52%
say it works well
4%
say it's a big hassle
892 reviews
Have you used Advil (Ibuprofen)?
Worth itNot sureNot worth it
Reviews for Tylenol #3 (Acetaminophen / Codeine)
69%
-19% worse vs. Advil (Ibuprofen)
41%
-11% worse vs. Advil (Ibuprofen)
9%
-5% worse vs. Advil (Ibuprofen)
581 reviews
Have you used Tylenol #3 (Acetaminophen / Codeine)?
Worth itNot sureNot worth it
Side effects
IbuprofenAcetaminophen With Codeine

We haven’t found good data for Ibuprofen side effects.

FDA side effect reports for Ibuprofen »

The Acetaminophen With Codeine FDA package insert doesn’t have numbers about how common side effects are.

More about Acetaminophen With Codeine side effects »
How it works
IbuprofenAcetaminophen With Codeine
Advil (Ibuprofen) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Tylenol #3 (Acetaminophen / Codeine) is a combination pain medicine. Codeine is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.
Type of medication
IbuprofenAcetaminophen With Codeine
Prescription or OTC
Prescription only
Available as
IbuprofenAcetaminophen With Codeine
  • Pill
  • Chewable tablet
  • Oral suspension
  • Pill
  • Liquid
Used for
IbuprofenAcetaminophen With Codeine
Risk factors for serious side effects
IbuprofenAcetaminophen With Codeine
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Smoking
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Hemophilia
  • von Willebrand's disease
  • Low blood platelet count
  • Taking anticoagulant medications
  • Asthma
  • Rhinitis
  • Nasal polyps
  • Aspirin allergy
  • NSAID allergy
  • Kidney disease
  • Heart failure
  • Liver disease
  • Taking high blood pressure medications
  • Age 65 years or older
  • Women of childbearing age
Detailed Advil (Ibuprofen) risks & warnings »
Coming soon.
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
IbuprofenAcetaminophen With Codeine
No alcohol related info.
  • Avoid alcohol.
Food
IbuprofenAcetaminophen With Codeine
  • It needs to be taken with food to avoid getting an upset stomach.
  • Take it with a meal or a snack to prevent upset stomach.
  • Take it with food to lower the chance of an upset stomach.
Kidneys and liver
IbuprofenAcetaminophen With Codeine
  • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • Advil (Ibuprofen) is an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Advil (Ibuprofen) for any amount of time.
  • Don't take more than instructed to prevent liver damage.
Pain
IbuprofenAcetaminophen With Codeine
  • Works well to relieve pain, swelling, and fevers.
  • Starts relieving pain in 30 to 60 minutes.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Good for as-needed pain and control.
  • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
  • Works best if you take it as soon as you start feeling pain.
  • Pain relief lasts 4-6 hours.
Sleep
IbuprofenAcetaminophen With Codeine
No sleep related info.
  • Can help you fall asleep easier.
  • Dizziness and drowsiness is common, but your body may adjust.
Upsides and benefits
IbuprofenAcetaminophen With Codeine
  • Works well to relieve pain, swelling, and fevers.
  • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
  • Ibuprofen works as well as aspirin in treating pain and causes fewer stomach problems.
  • Ibuprofen works better than acetaminophen (Tylenol) at lowering fever and relieving sinus pain.
  • Although not without side effects, it's been around for a long time and is generally safe for short-term use.
  • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relieve for mild to moderate pain to improve quality of life.
  • Good for as-needed pain and control.
  • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
Downsides and risks
IbuprofenAcetaminophen With Codeine
  • Ibuprofen doesn't work as long as other NSAIDs, so follow the package directions on how often you can take it.
  • It needs to be taken with food to avoid getting an upset stomach.
  • Can't be taken by pregnant women.
  • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
  • Like all NSAIDs, it can raise your risk of having blood clots, heart attack, or stroke.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Acetaminophen with codeine if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Acetaminophen with codeine, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
Tips from our pharmacists for people taking the medication
IbuprofenAcetaminophen With Codeine
  • Starts relieving pain in 30 to 60 minutes.
  • Take it with a meal or a snack to prevent upset stomach.
  • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
  • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
  • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
  • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
  • Starts working in 30 minutes.
  • Works best if you take it as soon as you start feeling pain.
  • Pain relief lasts 4-6 hours.
  • Can make you dizzy or drowsy.
  • Avoid activities need you to be fully alert until you know how it affects you.
  • Take it with food to lower the chance of an upset stomach.
  • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
  • Don't take more than instructed to prevent liver damage.
  • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
  • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
Learn more
More about IbuprofenSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Advil (Ibuprofen)?
Worth itNot sureNot worth it
More about Acetaminophen With CodeineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tylenol #3 (Acetaminophen / Codeine)?
Worth itNot sureNot worth it