Compare ibuprofen vs. Aspirin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Advil
(ibuprofen)

aspirin

Relieves pain, fever, and swelling. Advil (ibuprofen) works well for treating fever, inflammation, and a variety of mild to moderate pain conditions, but it doesn't last as long as other NSAIDs.Relieves pain, fever, and inflammation. Protects your heart and thins blood. A low dose of Aspirin (81mg) every day can protect your heart, but it's not the best medicine to take for pain, swelling, or fever.
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Coupons for ibuprofen
Best available price for 90 (800mg) tablets of ibuprofen
Coupons for Aspirin
Best available price for 30 (81mg) tablets of aspirin
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.49ibuprofen
Reviews for ibuprofen
88%
of people (All ages) say ibuprofen is worth it
52%
say it works well
4%
say it's a big hassle
892 reviews
Have you used Advil (ibuprofen)?
Worth itNot sureNot worth it
Reviews for Aspirin
76%
+12% better vs. ibuprofen
41%
+11% better vs. ibuprofen
6%
+2% better vs. ibuprofen
533 reviews
Have you used Aspirin?
Worth itNot sureNot worth it
Side effects
ibuprofenAspirin

The ibuprofen FDA package insert doesn’t have numbers about how common side effects are.

More about ibuprofen side effects »

We haven’t found good data for Aspirin side effects.

FDA side effect reports for Aspirin »
How it works
ibuprofenAspirin
Advil (ibuprofen) is a non-steroidal anti-inflammatory drug (NSAID). It stops the inflammation process in your body, which relieves pain, swelling, and fever.Aspirin is a salicylate and non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain. It also prevents blood platelets from forming clots, which thins your blood.
Type of medication
ibuprofenAspirin
Over-the-counterOver-the-counter
Available as
ibuprofenAspirin
  • Pill
  • Chewable tablet
  • Suspension
  • Pill
Used for
ibuprofenAspirin
Risk factors for serious side effects
ibuprofenAspirin
  • History of heart problems
  • Taking Advil (ibuprofen) for a long period of time
  • History of stomach bleeding
  • Age 60 or older
  • Taking aspirin, other NSAIDs, or blood thinners
Detailed Advil (ibuprofen) risks & warnings »
  • Children 18 years or younger
  • Children recovering from viral infections
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking Aspirin, NSAIDs, or blood thinners
Detailed Aspirin risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Food
ibuprofenAspirin
  • Take it with food or milk to prevent stomach upset.
  • It needs to be taken with food or millk to avoid getting an upset stomach.
  • Take with food to lower the chance of an upset stomach.
Kidneys and liver
ibuprofenAspirin
  • Advil (ibuprofen) can damage your kidneys. Taking the lowest dose for the shortest amount of time lowers your risk. Talk to your doctor if this worries you, or if you already have kidney damage before you start taking Advil (ibuprofen).
No kidneys and liver related info.
Pain
ibuprofenAspirin
  • Do not take for more than 10 days for pain relief or more than 3 days for fever. Talk to your doctor if your symptoms do not go away.
  • Good for relieving pain due to common conditions like menstrual cramps, toothaches, backaches, and sports-related injuries.
  • Used in higher doses to relieve pain, swelling, and fever.
Upsides and benefits
ibuprofenAspirin
  • Advil (ibuprofen) is effective for treating fever, pain, and inflammation.
  • Good for relieving pain due to common conditions like menstrual cramps, toothaches, backaches, and sports-related injuries.
  • Advil (ibuprofen) is generally safe to use, cheap, and available over-the-counter.
  • Advil (ibuprofen) causes less stomach problems than its alternatives.
  • It comes in different flavored liquid forms that makes it easy for children to take.
  • When taking low doses (81 mg) every day, Aspirin provides protection for your heart and prevents heart attacks and stroke.
  • Used in higher doses to relieve pain, swelling, and fever.
  • Available over-the-counter in drugstores by itself and in combination with other cold and flu medications.
Downsides and risks
ibuprofenAspirin
  • Advil (ibuprofen) doesn't last as long as other NSAIDs, so you need to take it a few times a day to get relief of your symptoms.
  • It needs to be taken with food or millk to avoid getting an upset stomach.
  • Advil (ibuprofen) is not as safe as other alternatives for pregnant women and people who are age 60 or older.
  • It can cause serious complications like stomach bleeding and kidney problems if taken for a long period of time.
  • Like all NSAIDs, Advil (ibuprofen) can raise your risk of getting blood clots, a heart attack, or stroke.
  • Not a preferred medication for treating pain, swelling, or fever due to its high risk of bleeding.
  • NSAIDs (like ibuprofen and naproxen) and acetaminophen (Tylenol) are better for treating pain and fever thank Aspirin.
  • Aspirin raises your risk of bleeding, especially when used with other blood thinner medications like warfarin (Coumadin).
  • Studies show that using higher doses of Aspirin (162 mg or more) every day raises your risk of stomach bleeding and doesn't provide any additional heart protection.
Tips from our pharmacists for people taking the medication
ibuprofenAspirin
  • Starts working in about 30 to 60 minutes.
  • Take it with food or milk to prevent stomach upset.
  • Do not take for more than 10 days for pain relief or more than 3 days for fever. Talk to your doctor if your symptoms do not go away.
  • If you normally take a daily aspirin, make sure to take Advil (ibuprofen) at least 30 minutes after taking aspirin or more than 8 hours before taking aspirin. This will help make sure the aspirin still works in your body.
  • Advil (ibuprofen) increases the risk of stomach bleeding so tell your doctor right away if you experience any bleeding.
  • If you are allergic to aspirin, there is a chance you may be allergic to Advil (ibuprofen) as well.
  • Using low doses (81mg) of Aspirin every day can lower your risk of heart attack and stroke, but it isn't good for everyone. Only take Aspirin daily if your doctor recommends it.
  • Higher Aspirin doses can be used to treat occasional pain, swelling, and fever. Using ibuprofen or acetaminophen (Tylenol) instead can lower your risk of serious bleeding.
  • Take with food to lower the chance of an upset stomach.
  • Don't use for kids younger than 18 years old.
  • Stop taking this right away and tell your doctor if you have ringing in your ears, unusual bleeding, or nausea or vomiting that doesn't go away.
Learn more
More about ibuprofenSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Advil (ibuprofen)?
Worth itNot sureNot worth it
More about AspirinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Aspirin?
Worth itNot sureNot worth it