Compare ibuprofen vs. Percocet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Advil
(ibuprofen)

Percocet
(oxycodone / acetaminophen)

Relieves pain, fever, and swelling. Advil (ibuprofen) works well for treating fever, inflammation, and a variety of mild to moderate pain conditions, but it doesn't last as long as other NSAIDs.Treats moderate to severe pain. Percocet (Oxycodone / Acetaminophen) is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.
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Coupons for ibuprofen
Best available price for 90 (800mg) tablets of ibuprofen
Coupons for Percocet
Best available price for 120 (5mg/325mg) tablets of percocet
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.49ibuprofen
Reviews for ibuprofen
88%
of people (All ages) say ibuprofen is worth it
52%
say it works well
4%
say it's a big hassle
892 reviews
Have you used Advil (ibuprofen)?
Worth itNot sureNot worth it
Reviews for Percocet
70%
+18% better vs. ibuprofen
49%
+3% better vs. ibuprofen
15%
+11% better vs. ibuprofen
1399 reviews
Have you used Percocet (oxycodone / acetaminophen)?
Worth itNot sureNot worth it
Side effects
ibuprofenPercocet

The ibuprofen FDA package insert doesn’t have numbers about how common side effects are.

More about ibuprofen side effects »

The Percocet FDA package insert doesn’t have numbers about how common side effects are.

More about Percocet side effects »
How it works
ibuprofenPercocet
Advil (ibuprofen) is a non-steroidal anti-inflammatory drug (NSAID). It stops the inflammation process in your body, which relieves pain, swelling, and fever.Percocet (Oxycodone / Acetaminophen) is a combination pain medicine. Oxycodone is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.
Type of medication
ibuprofenPercocet
Over-the-counterPrescription only
Available as
ibuprofenPercocet
  • Pill
  • Chewable tablet
  • Suspension
  • Pill
  • Oral solution
Used for
ibuprofenPercocet
Risk factors for serious side effects
ibuprofenPercocet
  • History of heart problems
  • Taking Advil (ibuprofen) for a long period of time
  • History of stomach bleeding
  • Age 60 or older
  • Taking aspirin, other NSAIDs, or blood thinners
Detailed Advil (ibuprofen) risks & warnings »
  • Current liver disease
  • Taking with alcohol
  • Taking other medicines with acetaminophen
  • Age 65 or greater
  • Higher dose
Detailed Percocet (oxycodone / acetaminophen) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
ibuprofenPercocet
No alcohol related info.
  • Avoid alcohol.
Food
ibuprofenPercocet
  • Take it with food or milk to prevent stomach upset.
  • It needs to be taken with food or millk to avoid getting an upset stomach.
  • Take it with food to lower the chance of an upset stomach.
Kidneys and liver
ibuprofenPercocet
  • Advil (ibuprofen) can damage your kidneys. Taking the lowest dose for the shortest amount of time lowers your risk. Talk to your doctor if this worries you, or if you already have kidney damage before you start taking Advil (ibuprofen).
  • The acetaminophen component in Percocet (Oxycodone / Acetaminophen) can hurt your liver. Using more than 4000 mg of the acetaminophen (or 12 tablets of Percocet (Oxycodone / Acetaminophen) can cause serious harm to your liver that may make you need a liver transplant and can be life-threatening. Don't take more than your doctor prescribes, and avoid other medicines that have acetaminophen when using Percocet (Oxycodone / Acetaminophen).
  • Don't take more than instructed to prevent liver damage.
Pain
ibuprofenPercocet
  • Do not take for more than 10 days for pain relief or more than 3 days for fever. Talk to your doctor if your symptoms do not go away.
  • Good for relieving pain due to common conditions like menstrual cramps, toothaches, backaches, and sports-related injuries.
  • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
  • Works best if you take it as soon as you start feeling pain.
  • Pain relief lasts 4-6 hours.
  • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
  • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Generally considered stronger than Norco or other combination pain medicine for treating pain.
Sleep
ibuprofenPercocet
No sleep related info.
  • Can help you fall asleep easier.
  • Dizziness and drowsiness is common, but your body may adjust.
Upsides and benefits
ibuprofenPercocet
  • Advil (ibuprofen) is effective for treating fever, pain, and inflammation.
  • Good for relieving pain due to common conditions like menstrual cramps, toothaches, backaches, and sports-related injuries.
  • Advil (ibuprofen) is generally safe to use, cheap, and available over-the-counter.
  • Advil (ibuprofen) causes less stomach problems than its alternatives.
  • It comes in different flavored liquid forms that makes it easy for children to take.
  • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relief for moderate to severe pain to improve quality of life.
  • Generally considered stronger than Norco or other combination pain medicine for treating pain.
  • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
Downsides and risks
ibuprofenPercocet
  • Advil (ibuprofen) doesn't last as long as other NSAIDs, so you need to take it a few times a day to get relief of your symptoms.
  • It needs to be taken with food or millk to avoid getting an upset stomach.
  • Advil (ibuprofen) is not as safe as other alternatives for pregnant women and people who are age 60 or older.
  • It can cause serious complications like stomach bleeding and kidney problems if taken for a long period of time.
  • Like all NSAIDs, Advil (ibuprofen) can raise your risk of getting blood clots, a heart attack, or stroke.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Percocet if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Percocet, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
Tips from our pharmacists for people taking the medication
ibuprofenPercocet
  • Starts working in about 30 to 60 minutes.
  • Take it with food or milk to prevent stomach upset.
  • Do not take for more than 10 days for pain relief or more than 3 days for fever. Talk to your doctor if your symptoms do not go away.
  • If you normally take a daily aspirin, make sure to take Advil (ibuprofen) at least 30 minutes after taking aspirin or more than 8 hours before taking aspirin. This will help make sure the aspirin still works in your body.
  • Advil (ibuprofen) increases the risk of stomach bleeding so tell your doctor right away if you experience any bleeding.
  • If you are allergic to aspirin, there is a chance you may be allergic to Advil (ibuprofen) as well.
  • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
  • Starts working in 30 minutes.
  • Works best if you take it as soon as you start feeling pain.
  • Pain relief lasts 4-6 hours.
  • Can make you dizzy or drowsy.
  • Avoid activities need you to be fully alert until you know how it affects you.
  • Take it with food to lower the chance of an upset stomach.
  • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
  • Don't take more than instructed to prevent liver damage.
  • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
  • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
Learn more
More about ibuprofenSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Advil (ibuprofen)?
Worth itNot sureNot worth it
More about PercocetSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Percocet (oxycodone / acetaminophen)?
Worth itNot sureNot worth it