Compare ibuprofen vs. Plavix

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Advil (ibuprofen)

Over-the-counter

Plavix (clopidogrel)

Prescription only
Relieves pain, fever, and swelling.

Advil (ibuprofen) works well for treating fever, inflammation, and a variety of mild to moderate pain conditions, but it doesn't last as long as other NSAIDs.

4.0/ 5 average rating with 892 reviewsforibuprofen
Prevents blood clots.

Plavix (clopidogrel) is a cheap, generically available blood thinner that protects you from clots after you've had a heart attack or surgery.

3.7/ 5 average rating with 343 reviewsforPlavix
Upsides
  • Advil (ibuprofen) is effective for treating fever, pain, and inflammation.
  • Good for relieving pain due to common conditions like menstrual cramps, toothaches, backaches, and sports-related injuries.
  • Advil (ibuprofen) is generally safe to use, cheap, and available over-the-counter.
  • Advil (ibuprofen) causes less stomach problems than its alternatives.
  • It comes in different flavored liquid forms that makes it easy for children to take.
  • Plavix (clopidogrel) can help lower your risk of getting a stroke or heart attack.
  • You only need to take it once a day.
  • A genetic test is available to determine whether Plavix (clopidogrel) will be an effective treatment option for you.
Downsides
  • Advil (ibuprofen) doesn't last as long as other NSAIDs, so you need to take it a few times a day to get relief of your symptoms.
  • It needs to be taken with food or millk to avoid getting an upset stomach.
  • Advil (ibuprofen) is not as safe as other alternatives for pregnant women and people who are age 60 or older.
  • It can cause serious complications like stomach bleeding and kidney problems if taken for a long period of time.
  • Like all NSAIDs, Advil (ibuprofen) can raise your risk of getting blood clots, a heart attack, or stroke.
  • Raises your risk of bleeding and bruising, which can be serious and life-threatening.
  • May not be safe to be taken with many other medicines or supplements.
  • If you've taken too much Plavix (clopidogrel) and you're bleeding, plasma transfusions are required to stop the bleeding.
Used for
Dosage forms
  • Pill
  • Chewable tablet
  • Suspension
  • Pill
Price
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Reviews
892 reviews so far
88%
saidit'sworth it
52%
saiditworked well
4%
saidit'sa big hassle

Have you used Advil (ibuprofen)?

Leave a review
343 reviews so far
59%
saidit'sworth it
49%
saiditworked well
16%
saidit'sa big hassle

Have you used Plavix (clopidogrel)?

Leave a review
Side effects
The Advil (ibuprofen) FDA package insert doesn’t have numbers about how common side effects are.
The Plavix (clopidogrel) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Heart attack and stroke
    • History of heart problems
    • Taking Advil (ibuprofen) for a long period of time
  • Stomach bleeding
    • History of stomach bleeding
    • Age 60 or older
    • Taking aspirin, other NSAIDs, or blood thinners
    • Drinking more than 3 alcoholic beverages a day
    • Smoking
    • Taking the medicine for a long period of time
  • Severe allergic reaction
    • Asthma
    • Nasal polyps
    • Aspirin allergy
    • NSAID allergy
  • Kidney damage
    • Kidney disease
    • Heart failure
    • Liver disease
    • Taking certain high blood pressure medications
    • Age 60 or older
    • Taking the medicine for a long period of time
  • Harm to fetus (unborn baby)
    • Women who want to or can become pregnant
    • Pregnant women
See more detailed risks and warnings
  • Weakened ability to prevent blood clots
    • Taking Prilosec or Nexium
    • People with certain genes that make Plavix (clopidogrel) less effective
  • Life-threatening bleeding
    • History of stomach bleeding
    • Taking other medicines that increase the levels of Plavix (clopidogrel) in your body
    • Taking other blood thinners or medicines that increase the risk of bleeding
  • Unexplained bruising and purple spots on skin
See more detailed risks and warnings