Compare Ibuprofen vs. Plavix

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Relieves pain, fever, and inflammation. Advil (Ibuprofen) works well for mild to moderate pain and inflammation, but it doesn't last as long as other NSAIDs.Prevents blood clots. Plavix (Clopidogrel) works well to prevent blood clots and heart complications, but watch out for drug interactions.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
Reviews for Advil (Ibuprofen)
of people say Advil (Ibuprofen) is worth it
say it works well
say it's a big hassle
865 reviews
Reviews for Plavix (Clopidogrel)
29% vs. Advil (Ibuprofen)
2% vs. Advil (Ibuprofen)
12% vs. Advil (Ibuprofen)
339 reviews
Side effects

We haven’t found good data for Ibuprofen side effects.

FDA side effect reports for Ibuprofen »
  • Minor bleeding 3%
  • Major bleeding 1%
  • Any noncerebral bleeding 1%
More Plavix side effects »
How it works
Advil (Ibuprofen) is a non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain.Plavix (Clopidogrel) is an antiplatelet blood thinner. It prevents blood platelets from working, which makes it harder for your body to form blood clots.
Type of medication
Pain reliever
Nonsteroidal anti-inflammatory drug (NSAID)
Prescription or OTC
Prescription only
Available as
  • Pill
  • Chewable tablet
  • Oral suspension
  • Pill
Used for (click to learn more)
Risk factors for serious side effects
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Smoking
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Hemophilia
  • von Willebrand's disease
  • Low blood platelet count
  • Taking anticoagulant medications
  • Asthma
  • Rhinitis
  • Nasal polyps
  • Aspirin allergy
  • NSAID allergy
  • Kidney disease
  • Heart failure
  • Liver disease
  • Taking high blood pressure medications
  • Age 65 years or older
  • Women of childbearing age
Detailed Advil (Ibuprofen) risks & warnings »
  • Genetic variation (CYP2C19 poor metabolizer)
  • Drug-interactions
  • Age greater than 65
  • History of gastrointestinal bleeding
  • High blood pressure
  • Liver problems
  • Drug interactions
  • Certain genetic disposition
    Detailed Plavix (Clopidogrel) risks & warnings »
    Pregnancy category
    DFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    BFDA pregnancy category (Probably safe)

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    See the FDA package insert
    No specific alcohol-related info.No specific alcohol-related info.
    • It needs to be taken with food to avoid getting an upset stomach.
    • Take it with a meal or a snack to prevent upset stomach.
    No specific food-related info.
    Kidneys and liver
    • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    • Advil (Ibuprofen) is an NSAID that can lower kidney function or cause damage. Taking the lowest dose for the shortest amount of time lowers your risk. Your doctor should check your kidney function if you take Advil (Ibuprofen) for any amount of time.
    No specific kidneys and liver-related info.
    No specific sex-related info.No specific sex-related info.
    No specific sleep-related info.No specific sleep-related info.
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    • Works well to relieve pain, swelling, and fevers.
    • Good for menstrual cramps, toothaches, body aches, and mild arthritis pain.
    • Ibuprofen works as well as aspirin in treating pain and causes fewer stomach problems.
    • Ibuprofen works better than acetaminophen (Tylenol) at lowering fever and relieving sinus pain.
    • Although not without side effects, it's been around for a long time and is generally safe for short-term use.
    • Thins your blood to protect your heart after a heart attack or after a procedure on your heart.
    • Studies have shown clopidogrel lowers your risk of death or further heart complications.
    Downsides and risks
    • Ibuprofen doesn't work as long as other NSAIDs, so follow the package directions on how often you can take it.
    • It needs to be taken with food to avoid getting an upset stomach.
    • Can't be taken by pregnant women.
    • It can cause serious kidney and stomach problems (like ulcers and bleeding) the longer you take it.
    • Like all NSAIDs, it can raise your risk of having blood clots, heart attack, or stroke.
    • Raises your risk of bleeding and bruising.
    • Lots of interactions with other drugs or supplements. Always check with your doctor or pharmacist before starting any new meds.
    • Doesn't work well for people with certain genetic variations.
    Tips from our pharmacists for people taking the medication
    • Starts relieving pain in 30 to 60 minutes.
    • Take it with a meal or a snack to prevent upset stomach.
    • Can make you bruise or bleed more easily and it can also cause stomach ulcers.
    • Don't take it with other blood thinners, like aspirin, unless your doctor tells you it's safe.
    • Can hurt your kidneys, so don't use it if you have a history of kidney problems.
    • Thins your blood to prevent clots from forming or getting bigger. Doesn't break up existing clots.
    • Can raise your risk of bleeding or bruising.
    • Take it exactly as instructed.
    • Interacts with a lot of medicines and supplements. Don't start any new meds without talking to your doctor.
    • Let your doctor know about any fever, weakness, or unusual bleeding or bruising.
    Learn more
    More about IbuprofenSide effectsReviews & ratingsAlternativesFDA package insert
    More about PlavixSide effectsReviews & ratingsAlternativesFDA package insert