Compare ibuprofen vs. Plavix

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Advil
(ibuprofen)

Plavix
(clopidogrel)

Relieves pain, fever, and swelling. Advil (ibuprofen) works well for treating fever, inflammation, and a variety of mild to moderate pain conditions, but it doesn't last as long as other NSAIDs.Prevents blood clots. Plavix (clopidogrel) is a cheap, generically available blood thinner that protects you from clots after you've had a heart attack or surgery.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.49ibuprofen
Reviews for ibuprofen
88%
of people (All ages) say ibuprofen is worth it
52%
say it works well
4%
say it's a big hassle
892 reviews
Have you used Advil (ibuprofen)?
Worth itNot sureNot worth it
Reviews for Plavix
59%
+29% better vs. ibuprofen
49%
+3% better vs. ibuprofen
16%
+12% better vs. ibuprofen
343 reviews
Have you used Plavix (clopidogrel)?
Worth itNot sureNot worth it
Side effects
ibuprofenPlavix

The ibuprofen FDA package insert doesn’t have numbers about how common side effects are.

More about ibuprofen side effects »
  • Minor bleeding 3%
  • Major bleeding 1%
More Plavix side effects »
How it works
ibuprofenPlavix
Advil (ibuprofen) is a non-steroidal anti-inflammatory drug (NSAID). It stops the inflammation process in your body, which relieves pain, swelling, and fever.Plavix (clopidogrel) is an antiplatelet blood thinner. It stops platelets in your blood from clumping together which makes it harder for them to form clots.
Type of medication
ibuprofenPlavix
Over-the-counterPrescription only
Available as
ibuprofenPlavix
  • Pill
  • Chewable tablet
  • Suspension
  • Pill
Used for
ibuprofenPlavix
Risk factors for serious side effects
ibuprofenPlavix
  • History of heart problems
  • Taking Advil (ibuprofen) for a long period of time
  • History of stomach bleeding
  • Age 60 or older
  • Taking aspirin, other NSAIDs, or blood thinners
Detailed Advil (ibuprofen) risks & warnings »
  • Taking Prilosec or Nexium
  • People with certain genes that make Plavix (clopidogrel) less effective
  • History of stomach bleeding
  • Taking other medicines that increase the levels of Plavix (clopidogrel) in your body
  • Taking other blood thinners or medicines that increase the risk of bleeding
Detailed Plavix (clopidogrel) risks & warnings »
Pregnancy
Food
ibuprofenPlavix
  • Take it with food or milk to prevent stomach upset.
  • It needs to be taken with food or millk to avoid getting an upset stomach.
No food related info.
Kidneys and liver
ibuprofenPlavix
  • Advil (ibuprofen) can damage your kidneys. Taking the lowest dose for the shortest amount of time lowers your risk. Talk to your doctor if this worries you, or if you already have kidney damage before you start taking Advil (ibuprofen).
No kidneys and liver related info.
Pain
ibuprofenPlavix
  • Do not take for more than 10 days for pain relief or more than 3 days for fever. Talk to your doctor if your symptoms do not go away.
  • Good for relieving pain due to common conditions like menstrual cramps, toothaches, backaches, and sports-related injuries.
No pain related info.
Upsides and benefits
ibuprofenPlavix
  • Advil (ibuprofen) is effective for treating fever, pain, and inflammation.
  • Good for relieving pain due to common conditions like menstrual cramps, toothaches, backaches, and sports-related injuries.
  • Advil (ibuprofen) is generally safe to use, cheap, and available over-the-counter.
  • Advil (ibuprofen) causes less stomach problems than its alternatives.
  • It comes in different flavored liquid forms that makes it easy for children to take.
  • Plavix (clopidogrel) can help lower your risk of getting a stroke or heart attack.
  • You only need to take it once a day.
  • A genetic test is available to determine whether Plavix (clopidogrel) will be an effective treatment option for you.
Downsides and risks
ibuprofenPlavix
  • Advil (ibuprofen) doesn't last as long as other NSAIDs, so you need to take it a few times a day to get relief of your symptoms.
  • It needs to be taken with food or millk to avoid getting an upset stomach.
  • Advil (ibuprofen) is not as safe as other alternatives for pregnant women and people who are age 60 or older.
  • It can cause serious complications like stomach bleeding and kidney problems if taken for a long period of time.
  • Like all NSAIDs, Advil (ibuprofen) can raise your risk of getting blood clots, a heart attack, or stroke.
  • Raises your risk of bleeding and bruising, which can be serious and life-threatening.
  • May not be safe to be taken with many other medicines or supplements.
  • If you've taken too much Plavix (clopidogrel) and you're bleeding, plasma transfusions are required to stop the bleeding.
Tips from our pharmacists for people taking the medication
ibuprofenPlavix
  • Starts working in about 30 to 60 minutes.
  • Take it with food or milk to prevent stomach upset.
  • Do not take for more than 10 days for pain relief or more than 3 days for fever. Talk to your doctor if your symptoms do not go away.
  • If you normally take a daily aspirin, make sure to take Advil (ibuprofen) at least 30 minutes after taking aspirin or more than 8 hours before taking aspirin. This will help make sure the aspirin still works in your body.
  • Advil (ibuprofen) increases the risk of stomach bleeding so tell your doctor right away if you experience any bleeding.
  • If you are allergic to aspirin, there is a chance you may be allergic to Advil (ibuprofen) as well.
  • Thins your blood to prevent clots from forming or getting bigger.
  • Can raise your risk of bleeding or bruising.
  • Take this medicine exactly as told by your doctor.
  • Plavix (clopidogrel) may not be safe to be taken together with some medicines and over-the-counter supplements. Don't start any new medicine without first speaking with your doctor or pharmacist.
  • Let your doctor know right away if you experience a fever, weakness, or unusual bleeding and bruising.
  • You should stop taking Plavix (clopidogrel) at least 5 days before any major surgeries to lower your chances of bleeding.
Learn more
More about ibuprofenSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Advil (ibuprofen)?
Worth itNot sureNot worth it
More about PlavixSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Plavix (clopidogrel)?
Worth itNot sureNot worth it