Compare ibuprofen vs. Plavix

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Advil
(ibuprofen)

Plavix
(clopidogrel)

Relieves pain, fever, and swelling. Advil (ibuprofen) works well for treating fever, inflammation, and a variety of mild to moderate pain conditions, but it doesn't last as long as other NSAIDs.Prevents blood clots. Plavix (Clopidogrel) works well to prevent blood clots and heart complications, but watch out for drug interactions.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for ibuprofen
Best available price for 90 (800mg) tablets of ibuprofen
Coupons for Plavix
Best available price for 30 (75mg) tablets of clopidogrel
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.49ibuprofen
Reviews for ibuprofen
88%
of people (All ages) say ibuprofen is worth it
52%
say it works well
4%
say it's a big hassle
892 reviews
Have you used Advil (ibuprofen)?
Worth itNot sureNot worth it
Reviews for Plavix
59%
+29% better vs. ibuprofen
49%
+3% better vs. ibuprofen
16%
+12% better vs. ibuprofen
343 reviews
Have you used Plavix (clopidogrel)?
Worth itNot sureNot worth it
Side effects
ibuprofenPlavix

The ibuprofen FDA package insert doesn’t have numbers about how common side effects are.

More about ibuprofen side effects »
  • Minor bleeding 3%
  • Major bleeding 1%
  • Any noncerebral bleeding 1%
More Plavix side effects »
How it works
ibuprofenPlavix
Advil (ibuprofen) is a non-steroidal anti-inflammatory drug (NSAID). It stops the inflammation process in your body, which relieves pain, swelling, and fever.Plavix (Clopidogrel) is an antiplatelet blood thinner. It prevents blood platelets from working, which makes it harder for your body to form blood clots.
Type of medication
ibuprofenPlavix
Over-the-counterPrescription only
Available as
ibuprofenPlavix
  • Pill
  • Chewable tablet
  • Suspension
  • Pill
Used for
ibuprofenPlavix
Risk factors for serious side effects
ibuprofenPlavix
  • History of heart problems
  • Taking Advil (ibuprofen) for a long period of time
  • History of stomach bleeding
  • Age 60 or older
  • Taking aspirin, other NSAIDs, or blood thinners
Detailed Advil (ibuprofen) risks & warnings »
  • Genetic variation (CYP2C19 poor metabolizer)
  • Drug-interactions
  • Age greater than 65
  • History of gastrointestinal bleeding
  • High blood pressure
Detailed Plavix (clopidogrel) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Interactions
ibuprofenPlavix
No interactions related info.
  • Lots of interactions with other drugs or supplements. Always check with your doctor or pharmacist before starting any new meds.
  • Interacts with a lot of medicines and supplements. Don't start any new meds without talking to your doctor.
Food
ibuprofenPlavix
  • It needs to be taken with food or millk to avoid getting an upset stomach.
  • Take it with food or milk to prevent stomach upset.
No food related info.
Kidneys and liver
ibuprofenPlavix
  • Advil (ibuprofen) can damage your kidneys. Taking the lowest dose for the shortest amount of time lowers your risk. Talk to your doctor if this worries you, or if you already have kidney damage before you start taking Advil (ibuprofen).
No kidneys and liver related info.
Pain
ibuprofenPlavix
  • Good for relieving pain due to common conditions like menstrual cramps, toothaches, backaches, and sports-related injuries.
  • Do not take for more than 10 days for pain relief or more than 3 days for fever. Talk to your doctor if your symptoms do not go away.
No pain related info.
Upsides and benefits
ibuprofenPlavix
  • Advil (ibuprofen) is effective for treating fever, pain, and inflammation.
  • Good for relieving pain due to common conditions like menstrual cramps, toothaches, backaches, and sports-related injuries.
  • Advil (ibuprofen) is generally safe to use, cheap, and available over-the-counter.
  • Advil (ibuprofen) causes less stomach problems than its alternatives.
  • It comes in different flavored liquid forms that makes it easy for children to take.
  • Thins your blood to protect your heart after a heart attack or after a procedure on your heart.
  • Studies have shown clopidogrel lowers your risk of death or further heart complications.
Downsides and risks
ibuprofenPlavix
  • Advil (ibuprofen) doesn't last as long as other NSAIDs, so you need to take it a few times a day to get relief of your symptoms.
  • It needs to be taken with food or millk to avoid getting an upset stomach.
  • Advil (ibuprofen) is not as safe as other alternatives for pregnant women and people who are age 60 or older.
  • It can cause serious complications like stomach bleeding and kidney problems if taken for a long period of time.
  • Like all NSAIDs, Advil (ibuprofen) can raise your risk of getting blood clots, a heart attack, or stroke.
  • Raises your risk of bleeding and bruising.
  • Lots of interactions with other drugs or supplements. Always check with your doctor or pharmacist before starting any new meds.
  • Doesn't work well for people with certain genetic variations.
Tips from our pharmacists for people taking the medication
ibuprofenPlavix
  • Starts working in about 30 to 60 minutes.
  • Take it with food or milk to prevent stomach upset.
  • Do not take for more than 10 days for pain relief or more than 3 days for fever. Talk to your doctor if your symptoms do not go away.
  • If you normally take a daily aspirin, make sure to take Advil (ibuprofen) at least 30 minutes after taking aspirin or more than 8 hours before taking aspirin. This will help make sure the aspirin still works in your body.
  • Advil (ibuprofen) increases the risk of stomach bleeding so tell your doctor right away if you experience any bleeding.
  • If you are allergic to aspirin, there is a chance you may be allergic to Advil (ibuprofen) as well.
  • Thins your blood to prevent clots from forming or getting bigger. Doesn't break up existing clots.
  • Can raise your risk of bleeding or bruising.
  • Take it exactly as instructed.
  • Interacts with a lot of medicines and supplements. Don't start any new meds without talking to your doctor.
  • Let your doctor know about any fever, weakness, or unusual bleeding or bruising.
Learn more
More about ibuprofenSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Advil (ibuprofen)?
Worth itNot sureNot worth it
More about PlavixSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Plavix (clopidogrel)?
Worth itNot sureNot worth it