Compare Imbruvica vs. Orencia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Imbruvica
(ibrutinib)

Orencia
(abatacept)

Coming soon.Calms down the immune system and prevents joint damage. Orencia (abatacept) slows the progress of rheumatoid arthritis, but can also cause serious side effects.
Reviews & ratings
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Have you used Imbruvica (ibrutinib)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Orencia (abatacept)?
Worth itNot sureNot worth it
Side effects
ImbruvicaOrencia

We haven’t found good data for Imbruvica side effects.

FDA side effect reports for Imbruvica »
  • Headache 5%
  • Common cold 3%
  • Dizziness 2%
  • Cough 1%
  • Back pain 1%
  • High blood pressure 3%
  • Indigestion 2%
  • Urinary tract infection 1%
  • Rash 1%
  • Pain in arms or legs 1%
More Orencia side effects »
How it works
ImbruvicaOrencia
Coming soon.Orencia (abatacept) is a biologic DMARD (disease-modifying anti-rheumatic drug) - sometimes just called a "biologic". It prevents your body from activating the cells that cause inflammation.
Type of medication
ImbruvicaOrencia
Prescription only
Available as
ImbruvicaOrencia
  • Pill
  • Infusion
  • Injection
Used for
ImbruvicaOrencia
  • Chronic Lymphoid Leukemia
Risk factors for serious side effects
ImbruvicaOrencia
    Coming soon.
    • Using TNF inhibitors
    • Taking immunosuppressive medications
    • History of repeat infections
    • Adults with rheumatoid arthritis taking TNF inhibitors
    • COPD
    Detailed Orencia (abatacept) risks & warnings »
    Pregnancy

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Upsides and benefits
    ImbruvicaOrencia
    Coming soon
    • In a 2-year study that used IV Orencia (abatacept) with methotrexate, more than half of the people had remission and the majority felt significantly better.
    • Helps minimize joint damage, lowers symptoms, and prevents future problems. People taking Orencia (abatacept) had no new joint damage after two years.
    • Taking Orencia (abatacept) allows RA patients to use less prednisone, a steroid that has many side effects.
    • You can give yourself Orencia (abatacept) subcutaneously on your own at home rather than visiting a clinic or hospital.
    • Available in a prefilled autoinjector for convenient use.
    Downsides and risks
    ImbruvicaOrencia
    Coming soon
    • Orencia (abatacept) can be costly.
    • The IV infusion form of Orencia (abatacept) can cause a reaction, which ranges from a slight itching or warm feeling to more serious side effects such as low blood pressure and chest pain.
    • The IV infusion form of Orencia (abatacept) contains maltose, a type of sugar, that can give false high blood sugar readings with certain types of blood sugar monitors on the day of Orencia (abatacept) infusion. The self-injection subcutaneous form does not contain maltose. Talk to your doctor if you have diabetes.
    • If you need TNF inhibitors as part of your treatment, it is not recommended to take Orencia (abatacept). If you have COPD, you are at higher risk of side effects.
    • Orencia (abatacept) lowers your ability to fight infection. Your risk can increase if you take medications that lower your immune system or have an active infection. You may need to get tested for tuberculosis before starting Orencia (abatacept).
    Tips from our pharmacists for people taking the medication
    ImbruvicaOrencia
    Coming soon
    • If you are using the IV version of Orencia (abatacept), you will only need to get infusions once a month (after the first initial doses). It takes about 30 minutes to give the full dose of medicine. Stay hydrated and ask your nurse to apply dry heat (instant warm packs) to your arm to help find your good veins.
    • The self-injections are taken once a week. You or your caregiver should receive training on the proper way to prepare and inject Orencia (abatacept).
    • Keep the Orencia (abatacept) self-injection refrigerated, and let it rest at room temperature for 30 minutes before using it.
    • Each time you use Orencia (abatacept), it's important to rotate the sites you chose to inject it in. Don't inject Orencia (abatacept) into skin that's red, bruised, or irritated.
    • Talk with your doctor before getting any vaccines. Use of this drug may either raise the chance of an infection or make the vaccine not work as well.
    • As with all injection medicines, store it securely away from children and throw away used syringes in an FDA-approved sharps disposal container, never in the trash.
    Learn more
    More about ImbruvicaSide effectsReviews & ratingsFDA package insert
    Have you used Imbruvica (ibrutinib)?
    Worth itNot sureNot worth it
    More about OrenciaSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Orencia (abatacept)?
    Worth itNot sureNot worth it