Compare Imitrex vs. Amerge

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Imitrex
(sumatriptan)

Amerge
(naratriptan)

Treats migraine headaches. Imitrex (Sumatriptan) is an excellent choice for acute migraine relief, but you might need another medication to prevent headaches.Treats migraine headaches. Amerge (naratriptan) isn't as good as other similar medications for migraines, but can be good if other drugs haven't worked for you.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.29Imitrex
Reviews for Imitrex
74%
of people (All ages) say Imitrex is worth it
68%
say it works well
19%
say it's a big hassle
Have you used Imitrex (sumatriptan)?
Worth itNot sureNot worth it

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Have you used Amerge (naratriptan)?
Worth itNot sureNot worth it
Side effects
ImitrexAmerge
  • Pain and other pressure sensations 2%
  • Atypical sensations 1%
  • Paresthesia (all types) 1%
  • Sensation warm/cold 1%
  • Pain - location specified 1%
  • Malaise/fatigue 2%
  • Chest - pain/tightness/pressure and/or heaviness 1%
  • Neck/throat/jaw - pain/ tightness/pressure 2%
  • Other - pressure/tightness/ heaviness 1%
  • Vertigo 2%
More Imitrex side effects »
  • Stomach problems 1%
  • Nervous system issues 1%
  • Unusual sensation 1%
  • Fatigue or uneasiness 1%
  • Tingling or prickling sensation 2%
  • Dizziness 1%
  • Drowsiness 2%
  • Pain & pressure in throat or neck 1%
More Amerge side effects »
How it works
ImitrexAmerge
Imitrex (Sumatriptan) is a triptan medication that treats migraine headaches. It releases serotonin, which lowers the inflammation that causes headaches.Amerge (naratriptan) is a selective serotonin receptor agonist or triptan. Migraine headaches happen when blood vessels are too open and allow too much blood in the brain. Amerge (naratriptan) tightens the blood vessels which relieves the pain.
Type of medication
ImitrexAmerge
Prescription onlyPrescription only
Available as
ImitrexAmerge
  • Pill
  • Injection
  • Nasal spray
  • Pill
Used for
ImitrexAmerge
Risk factors for serious side effects
ImitrexAmerge
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
Detailed Imitrex (sumatriptan) risks & warnings »
  • Heart disease
  • history of chest pain/angina
  • uncontrolled high blood pressure
  • History of a stroke
  • Using Amerge (naratriptan) for more than 10 days a month
Detailed Amerge (naratriptan) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Sleep
ImitrexAmerge
  • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
No sleep related info.
Upsides and benefits
ImitrexAmerge
  • Comes in several forms. Ask your doctor if you should use the pill, nasal spray, patch, or injection.
  • A combination of forms can be used if symptoms do not improve.
  • The nasal spray and injectable forms work very quickly.
  • It's generally safe to use if you are pregnant.
  • Comes in a generic form, so it can be pretty cheap.
  • Amerge (naratriptan) is a good alternative to other triptans since it's less likely to cause side effects and if other triptans haven't worked for you.
  • Available as a generic, which makes it cheaper than other medicines and is more likely to be covered by insurances.
  • Amerge (naratriptan) comes in two different strengths.
Downsides and risks
ImitrexAmerge
  • The oral and nasal versions of Imitrex (Sumatriptan) have an unpleasant after-taste.
  • Does not prevent migraine headaches; it only treats them once they start.
  • Must wait 1 hour before using second injection.
  • Can cause rebound (more) headaches if Imitrex (Sumatriptan) is used too often.
  • Need to have your blood pressure checked often, especially if you're pregnant.
  • Amerge (naratriptan) is only available as a pill that must be swallowed, so it might not be good if you have trouble swallowing when you have a migraine.
  • Unlike other migraine medications, you have to wait for 4 hours before you can take the second dose of Amerge (naratriptan).
  • Amerge (naratriptan) is not as good as other medications for treating nausea that can happen with migraines.
Tips from our pharmacists for people taking the medication
ImitrexAmerge
  • Take it as soon as your headache starts.
  • If you use the nasal spray, be sure to blow your nose before using it.
  • If you use the patch, put it on a dry area free of scars, tattoos, or other cuts and scrapes. Be sure to press the button to activate it.
  • If you use the injection, you can use a second injection if you still have a headache after an hour. If you have symptoms 2 hours after the injection, switch to the pill version.
  • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
  • Lie down in a dark room after taking Imitrex (Sumatriptan) to help ease the pain.
  • Amerge (naratriptan) can only treat a migraine that's already happening. Amerge (naratriptan) doesn't prevent migraines.
  • Take Amerge (naratriptan) at the first sign of a migraine. You can take another dose if you don't feel better after 4 hours. Don't take more than two doses every 24 hours.
  • Amerge (naratriptan) can make you feel dizzy or tired when you first start taking it. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • If you finish the entire month's supply of Amerge (naratriptan) before it's time for your next refill, or if you have more than 4 migraines a month, talk to your doctor to see if you should try something else.
  • Amerge (naratriptan) can cause nausea or tightness in the chest or throat. Talk to your doctor if it bothers you.
Learn more
More about ImitrexSide effectsReviews & ratingsFDA package insert
Have you used Imitrex (sumatriptan)?
Worth itNot sureNot worth it
More about AmergeSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Amerge (naratriptan)?
Worth itNot sureNot worth it